Evaluation of efficacy and safety of a herbal medicine used for the treatment of malaria
Resistance of Plasmodium falciparum to chloroquine has been reported in several countries. Other anti‐malarial drugs in use are expensive and not readily accessible to most people in malaria endemic countries. This has led to renewed interest in the development of herbal medicines that have the pote...
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| Veröffentlicht in: | Phytotherapy research 2003-06, Vol.17 (6), p.697-701 |
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| creator | Ankrah, Nii-Ayi Nyarko, Alexander K. Addo, Phyllis G. A. Ofosuhene, Mark Dzokoto, Comfort Marley, Ethel Addae, Michael M. Ekuban, Frederick A. |
| description | Resistance of Plasmodium falciparum to chloroquine has been reported in several countries. Other anti‐malarial drugs in use are expensive and not readily accessible to most people in malaria endemic countries. This has led to renewed interest in the development of herbal medicines that have the potential to treat malaria with little or no side effects. This study obtained a preliminary information on the safety and effectiveness of a plant decoction (AM‐1), used in treating malaria.
The AM‐1 is formulated from Jatropha curcas, Gossypium hirsutum, Physalis angulata and Delonix regia. Patients with suspected malaria attending a herbal clinic were enrolled in the study on voluntary basis. They were hospitalized for treatment, clinical observation, biochemical and haematological monitoring, and parasite clearance while on AM‐1. In addition male and female Sprague Dawley rats were used to evaluate the acute and subchronic toxicity effects of AM‐1.
The AM‐1 eliminated malaria parasites (Plasmodium falciparum and Plasmodium malarie) from the peripheral blood of patients with malaria. In addition the AM‐1 did not show any undesired effects in the patients as well as in laboratory rats. The AM‐1, however, showed differential effect on the activities of selected cytochrome P450 isozymes (7‐pentoxyresorufin‐O‐depentylation, 7‐ethoxyresorufin‐O‐deethylation and p‐nitrophenol hydroxylase) in relation to sex of the laboratory rats.
These results indicate that AM‐1 could be used to treat malaria. However, it could precipitate interactions with other drugs via their biotransformation and elimination. The obtained data warrant further studies in a large number of malaria subjects with monitoring for possible drug interactions. Copyright © 2003 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.1196 |
| format | Article |
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The AM‐1 is formulated from Jatropha curcas, Gossypium hirsutum, Physalis angulata and Delonix regia. Patients with suspected malaria attending a herbal clinic were enrolled in the study on voluntary basis. They were hospitalized for treatment, clinical observation, biochemical and haematological monitoring, and parasite clearance while on AM‐1. In addition male and female Sprague Dawley rats were used to evaluate the acute and subchronic toxicity effects of AM‐1.
The AM‐1 eliminated malaria parasites (Plasmodium falciparum and Plasmodium malarie) from the peripheral blood of patients with malaria. In addition the AM‐1 did not show any undesired effects in the patients as well as in laboratory rats. The AM‐1, however, showed differential effect on the activities of selected cytochrome P450 isozymes (7‐pentoxyresorufin‐O‐depentylation, 7‐ethoxyresorufin‐O‐deethylation and p‐nitrophenol hydroxylase) in relation to sex of the laboratory rats.
These results indicate that AM‐1 could be used to treat malaria. However, it could precipitate interactions with other drugs via their biotransformation and elimination. The obtained data warrant further studies in a large number of malaria subjects with monitoring for possible drug interactions. Copyright © 2003 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.1196</identifier><identifier>PMID: 12820245</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adolescent ; Adult ; AM-1 ; Animals ; Antimalarials - administration & dosage ; Antimalarials - adverse effects ; Antimalarials - pharmacology ; Antimalarials - therapeutic use ; Biological and medical sciences ; Child ; Cytochrome P-450 Enzyme System - drug effects ; Drug Interactions ; Fabaceae ; Female ; General pharmacology ; Gossypium ; Humans ; Jatropha ; Liver - drug effects ; Liver - enzymology ; malaria ; Malaria - drug therapy ; Male ; Medical sciences ; P. falciparum ; P. falciparum, P. malariae, AM‐1 ; P. malariae ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Physalis ; Phytotherapy ; Plant Extracts - administration & dosage ; Plant Extracts - adverse effects ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plants, Medicinal ; Plasmodium falciparum - drug effects ; Plasmodium malariae - drug effects ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Phytotherapy research, 2003-06, Vol.17 (6), p.697-701</ispartof><rights>Copyright © 2003 John Wiley & Sons, Ltd.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4196-1303b19a3ea829acd1fbcc93bad4b49236dd3af6fa67507aced76c4d8df08a273</citedby><cites>FETCH-LOGICAL-c4196-1303b19a3ea829acd1fbcc93bad4b49236dd3af6fa67507aced76c4d8df08a273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.1196$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.1196$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14898185$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12820245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ankrah, Nii-Ayi</creatorcontrib><creatorcontrib>Nyarko, Alexander K.</creatorcontrib><creatorcontrib>Addo, Phyllis G. A.</creatorcontrib><creatorcontrib>Ofosuhene, Mark</creatorcontrib><creatorcontrib>Dzokoto, Comfort</creatorcontrib><creatorcontrib>Marley, Ethel</creatorcontrib><creatorcontrib>Addae, Michael M.</creatorcontrib><creatorcontrib>Ekuban, Frederick A.</creatorcontrib><title>Evaluation of efficacy and safety of a herbal medicine used for the treatment of malaria</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>Resistance of Plasmodium falciparum to chloroquine has been reported in several countries. Other anti‐malarial drugs in use are expensive and not readily accessible to most people in malaria endemic countries. This has led to renewed interest in the development of herbal medicines that have the potential to treat malaria with little or no side effects. This study obtained a preliminary information on the safety and effectiveness of a plant decoction (AM‐1), used in treating malaria.
The AM‐1 is formulated from Jatropha curcas, Gossypium hirsutum, Physalis angulata and Delonix regia. Patients with suspected malaria attending a herbal clinic were enrolled in the study on voluntary basis. They were hospitalized for treatment, clinical observation, biochemical and haematological monitoring, and parasite clearance while on AM‐1. In addition male and female Sprague Dawley rats were used to evaluate the acute and subchronic toxicity effects of AM‐1.
The AM‐1 eliminated malaria parasites (Plasmodium falciparum and Plasmodium malarie) from the peripheral blood of patients with malaria. In addition the AM‐1 did not show any undesired effects in the patients as well as in laboratory rats. The AM‐1, however, showed differential effect on the activities of selected cytochrome P450 isozymes (7‐pentoxyresorufin‐O‐depentylation, 7‐ethoxyresorufin‐O‐deethylation and p‐nitrophenol hydroxylase) in relation to sex of the laboratory rats.
These results indicate that AM‐1 could be used to treat malaria. However, it could precipitate interactions with other drugs via their biotransformation and elimination. The obtained data warrant further studies in a large number of malaria subjects with monitoring for possible drug interactions. Copyright © 2003 John Wiley & Sons, Ltd.</description><subject>Adolescent</subject><subject>Adult</subject><subject>AM-1</subject><subject>Animals</subject><subject>Antimalarials - administration & dosage</subject><subject>Antimalarials - adverse effects</subject><subject>Antimalarials - pharmacology</subject><subject>Antimalarials - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Cytochrome P-450 Enzyme System - drug effects</subject><subject>Drug Interactions</subject><subject>Fabaceae</subject><subject>Female</subject><subject>General pharmacology</subject><subject>Gossypium</subject><subject>Humans</subject><subject>Jatropha</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>malaria</subject><subject>Malaria - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>P. falciparum</subject><subject>P. falciparum, P. malariae, AM‐1</subject><subject>P. malariae</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Physalis</subject><subject>Phytotherapy</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - adverse effects</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plants, Medicinal</subject><subject>Plasmodium falciparum - drug effects</subject><subject>Plasmodium malariae - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10FtLwzAUB_AgiptT8BNIXgRfOpOmtzyqeIM5dSqKL-E0Fxbt2pF0ar-9LSvuyacDhx_n8kfokJIxJSQ8XdZuTClPttCQEs4DGqdsGw0Jj2kQ0extgPa8_yCE8JBEu2hAwywkYRQP0dvlFxQrqG1V4spgbYyVIBsMpcIejK6brg14rl0OBV5oZaUtNV55rbCpHK7nGtdOQ73QZd3ZBRTgLOyjHQOF1wd9HaGXq8vni5tgcn99e3E2CWTUHhxQRlhOOTANWchBKmpyKTnLQUV5xEOWKMXAJAaSNCYpSK3SREYqU4ZkEKZshE7Wc6WrvHfaiKWzC3CNoER04Yg2HNGF09KjNV2u8vaRDezTaMFxD8BLKIyDUlq_cVHGM5p1Lli7b1vo5t-F4uF51i_uvfW1_vnz4D5FkrI0Fq_TazGbPr6Tu_MnccV-AYlziy4</recordid><startdate>200306</startdate><enddate>200306</enddate><creator>Ankrah, Nii-Ayi</creator><creator>Nyarko, Alexander K.</creator><creator>Addo, Phyllis G. A.</creator><creator>Ofosuhene, Mark</creator><creator>Dzokoto, Comfort</creator><creator>Marley, Ethel</creator><creator>Addae, Michael M.</creator><creator>Ekuban, Frederick A.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200306</creationdate><title>Evaluation of efficacy and safety of a herbal medicine used for the treatment of malaria</title><author>Ankrah, Nii-Ayi ; Nyarko, Alexander K. ; Addo, Phyllis G. A. ; Ofosuhene, Mark ; Dzokoto, Comfort ; Marley, Ethel ; Addae, Michael M. ; Ekuban, Frederick A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4196-1303b19a3ea829acd1fbcc93bad4b49236dd3af6fa67507aced76c4d8df08a273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>AM-1</topic><topic>Animals</topic><topic>Antimalarials - administration & dosage</topic><topic>Antimalarials - adverse effects</topic><topic>Antimalarials - pharmacology</topic><topic>Antimalarials - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Cytochrome P-450 Enzyme System - drug effects</topic><topic>Drug Interactions</topic><topic>Fabaceae</topic><topic>Female</topic><topic>General pharmacology</topic><topic>Gossypium</topic><topic>Humans</topic><topic>Jatropha</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>malaria</topic><topic>Malaria - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>P. falciparum</topic><topic>P. falciparum, P. malariae, AM‐1</topic><topic>P. malariae</topic><topic>Pharmacognosy. 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A.</creatorcontrib><creatorcontrib>Ofosuhene, Mark</creatorcontrib><creatorcontrib>Dzokoto, Comfort</creatorcontrib><creatorcontrib>Marley, Ethel</creatorcontrib><creatorcontrib>Addae, Michael M.</creatorcontrib><creatorcontrib>Ekuban, Frederick A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ankrah, Nii-Ayi</au><au>Nyarko, Alexander K.</au><au>Addo, Phyllis G. A.</au><au>Ofosuhene, Mark</au><au>Dzokoto, Comfort</au><au>Marley, Ethel</au><au>Addae, Michael M.</au><au>Ekuban, Frederick A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of efficacy and safety of a herbal medicine used for the treatment of malaria</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2003-06</date><risdate>2003</risdate><volume>17</volume><issue>6</issue><spage>697</spage><epage>701</epage><pages>697-701</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>Resistance of Plasmodium falciparum to chloroquine has been reported in several countries. Other anti‐malarial drugs in use are expensive and not readily accessible to most people in malaria endemic countries. This has led to renewed interest in the development of herbal medicines that have the potential to treat malaria with little or no side effects. This study obtained a preliminary information on the safety and effectiveness of a plant decoction (AM‐1), used in treating malaria.
The AM‐1 is formulated from Jatropha curcas, Gossypium hirsutum, Physalis angulata and Delonix regia. Patients with suspected malaria attending a herbal clinic were enrolled in the study on voluntary basis. They were hospitalized for treatment, clinical observation, biochemical and haematological monitoring, and parasite clearance while on AM‐1. In addition male and female Sprague Dawley rats were used to evaluate the acute and subchronic toxicity effects of AM‐1.
The AM‐1 eliminated malaria parasites (Plasmodium falciparum and Plasmodium malarie) from the peripheral blood of patients with malaria. In addition the AM‐1 did not show any undesired effects in the patients as well as in laboratory rats. The AM‐1, however, showed differential effect on the activities of selected cytochrome P450 isozymes (7‐pentoxyresorufin‐O‐depentylation, 7‐ethoxyresorufin‐O‐deethylation and p‐nitrophenol hydroxylase) in relation to sex of the laboratory rats.
These results indicate that AM‐1 could be used to treat malaria. However, it could precipitate interactions with other drugs via their biotransformation and elimination. The obtained data warrant further studies in a large number of malaria subjects with monitoring for possible drug interactions. Copyright © 2003 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>12820245</pmid><doi>10.1002/ptr.1196</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Phytotherapy research, 2003-06, Vol.17 (6), p.697-701 |
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| language | eng |
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| subjects | Adolescent Adult AM-1 Animals Antimalarials - administration & dosage Antimalarials - adverse effects Antimalarials - pharmacology Antimalarials - therapeutic use Biological and medical sciences Child Cytochrome P-450 Enzyme System - drug effects Drug Interactions Fabaceae Female General pharmacology Gossypium Humans Jatropha Liver - drug effects Liver - enzymology malaria Malaria - drug therapy Male Medical sciences P. falciparum P. falciparum, P. malariae, AM‐1 P. malariae Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Physalis Phytotherapy Plant Extracts - administration & dosage Plant Extracts - adverse effects Plant Extracts - pharmacology Plant Extracts - therapeutic use Plants, Medicinal Plasmodium falciparum - drug effects Plasmodium malariae - drug effects Rats Rats, Sprague-Dawley |
| title | Evaluation of efficacy and safety of a herbal medicine used for the treatment of malaria |
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