M 1 muscarinic receptor activation decreases alcohol consumption via a reduction in consummatory behavior

Muscarinic acetylcholine receptors (mAChRs) have been shown to mediate alcohol consumption and seeking. Both M and M mAChRs have been highlighted as potential novel treatment targets for alcohol use disorders (AUD). Similarly, M mAChRs are expressed throughout reward circuitry, and their signaling h...

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Veröffentlicht in:	Pharmacology research & perspectives 2022-02, Vol.10 (1), p.e00907
Hauptverfasser:	Walker, Leigh C, Campbell, Erin J, Huckstep, Kate L, Chen, Nicola A, Langmead, Christopher J, Lawrence, Andrew J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Drinking - metabolism Alcoholism - physiopathology Alcoholism - therapy Animals Consummatory Behavior - drug effects Male Picolinic Acids - pharmacology Rats Receptor, Muscarinic M1 - agonists Receptor, Muscarinic M1 - metabolism Reward Self Administration Sucrose - administration & dosage Thiazoles - pharmacology
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