Allosteric effects of the antipsychotic drug trifluoperazine on the energetics of calcium binding by calmodulin

Trifluoperazine (TFP; Stelazine™) is an antagonist of calmodulin (CaM), an essential regulator of calcium‐dependent signal transduction. Reports differ regarding whether, or where, TFP binds to apo CaM. Three crystallographic structures (1CTR, 1A29, and 1LIN) show TFP bound to (Ca2+)4‐CaM in ratios...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2010-08, Vol.78 (10), p.2265-2282
Hauptverfasser:	Feldkamp, Michael D., O'Donnell, Susan E., Yu, Liping, Shea, Madeline A.
Format:	Artikel
Sprache:	eng
Schlagworte:	15N-HSQC allostery Animals Antipsychotic Agents - chemistry Antipsychotic Agents - metabolism binding Binding Sites - drug effects Calcium - chemistry Calcium - metabolism Calcium Signaling - drug effects Calmodulin - antagonists & inhibitors Calmodulin - blood Calmodulin - chemistry Calmodulin - genetics Calmodulin - metabolism Computational Biology Databases, Protein Kinetics Ligands linkage Models, Molecular NMR Nuclear Magnetic Resonance, Biomolecular Osmolar Concentration Paramecium - metabolism Peptide Fragments - blood Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Protein Binding - drug effects Protein Conformation Protein Interaction Domains and Motifs Recombinant Proteins - chemistry Recombinant Proteins - isolation & purification Recombinant Proteins - metabolism titration Trifluoperazine - chemistry Trifluoperazine - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!