Role of the TNF-α receptor type 1 on prostate carcinogenesis in knockout mice

BACKGROUND TNF‐α is a key cytokine involved in prostate carcinogenesis and is mediated by the TNF‐α receptor type 1 (TNFR‐1). This receptor triggers two opposite pathways: cell death or cell survival and presents a protective or stimulator role in cancer. Thus, the purpose of this study was to evalu...

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Veröffentlicht in:	The Prostate 2016-07, Vol.76 (10), p.917-926
Hauptverfasser:	Galheigo, Maria Raquel Unterkircher, Cruz, Amanda Rodrigues, Cabral, Ágata Silva, Faria, Paulo Rogério, Cordeiro, Renato Simões, Silva, Marcelo José Barbosa, Tomiosso, Tatiana Carla, Gonçalves, Bianca Fachim, Pinto-Fochi, Maria Etelvina, Taboga, Sebastião Roberto, Góes, Rejane Maira, Ribeiro, Daniele Lisboa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology AKT/mTOR Animals Apoptosis carcinogenesis Carcinogenesis - pathology Cell Proliferation Cell Survival Male Mice Mice, Inbred C57BL Mice, Knockout NF-kappa B - metabolism Proliferating Cell Nuclear Antigen - analysis prostate Prostatic Intraepithelial Neoplasia - pathology Prostatic Neoplasms - chemistry Prostatic Neoplasms - pathology Proto-Oncogene Proteins c-akt - metabolism Receptors, Androgen - analysis Receptors, Tumor Necrosis Factor, Type I - deficiency Receptors, Tumor Necrosis Factor, Type I - genetics Receptors, Tumor Necrosis Factor, Type I - physiology TNF-α TNFR-1 TOR Serine-Threonine Kinases - analysis TOR Serine-Threonine Kinases - metabolism Transcription Factor RelA - analysis Tumor Necrosis Factor-alpha - physiology
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