Regulation of androgen receptor transactivity and mTOR-S6 kinase pathway by Rheb in prostate cancer cell proliferation

BACKGROUND Ras homolog‐enriched in brain (Rheb), a small GTP‐binding protein, is associated with prostate carcinogenesis through activating mammalian target of rapamycin (mTOR) signaling pathway. This study aimed to elucidate whether Rheb promotes proliferation of prostate cancer cells and can act a...

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Veröffentlicht in:	The Prostate 2010-06, Vol.70 (8), p.866-874
Hauptverfasser:	Kobayashi, Takashi, Shimizu, Yosuke, Terada, Naoki, Yamasaki, Toshinari, Nakamura, Eijiro, Toda, Yoshinobu, Nishiyama, Hiroyuki, Kamoto, Toshiyuki, Ogawa, Osamu, Inoue, Takahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Cell Count Cell Cycle - physiology Cell Line, Tumor Cell Proliferation Flow Cytometry Humans Immunohistochemistry Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism kinase inhibitor Male molecular-target therapy Monomeric GTP-Binding Proteins - genetics Monomeric GTP-Binding Proteins - metabolism Neuropeptides - genetics Neuropeptides - metabolism Prostate - metabolism prostatic adenocarcinoma Prostatic Hyperplasia - genetics Prostatic Hyperplasia - metabolism Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Ras Homolog Enriched in Brain Protein Receptors, Androgen - genetics Receptors, Androgen - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism signal transduction Signal Transduction - physiology TOR Serine-Threonine Kinases
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