PTEN-mediated G1 cell-cycle arrest in LNCaP prostate cancer cells is associated with altered expression of cell-cycle regulators

BACKGROUND The tumor suppressor PTEN regulates many biological processes. A well‐known downstream effector of PTEN is phospho‐Akt. Although PTEN is the most frequently inactivated gene in prostate cancer, its mode of action is not fully understood. We studied the association of regulated PTEN expres...

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Veröffentlicht in:	The Prostate 2010-02, Vol.70 (2), p.135-146
Hauptverfasser:	van Duijn, P.W., Ziel-van der Made, A.C.J., van der Korput, J.A.G., Trapman, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	cell cycle Cell Cycle - genetics Cell Cycle Proteins - genetics Cell Line, Tumor Cell Proliferation gene expression Gene Expression Profiling Humans Male Oligonucleotide Array Sequence Analysis prostate cancer Prostatic Neoplasms - genetics PTEN PTEN Phosphohydrolase - genetics Transfection
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