Anti-PSMA immunotoxin as novel treatment for prostate cancer? High and specific antitumor activity on human prostate xenograft tumors in SCID mice

BACKGROUND Expression of the prostate specific membrane antigen (PSMA) is highly restricted to prostate epithelial cells. Therefore, toxin‐based immunotherapy against this antigen may represent an alternative therapeutic option for prostate cancer. For these purposes, the effects of the recombinant...

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Veröffentlicht in:	The Prostate 2008-02, Vol.68 (2), p.129-138
Hauptverfasser:	Wolf, Philipp, Alt, Karen, Bühler, Patrick, Katzenwadel, Arndt, Wetterauer, Ulrich, Tacke, Marlene, Elsässer-Beile, Ursula
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP Ribose Transferases - immunology ADP Ribose Transferases - therapeutic use Animals Antibody Specificity - immunology Antineoplastic Agents - immunology Antineoplastic Agents - therapeutic use Bacterial Toxins - immunology Bacterial Toxins - therapeutic use Biological and medical sciences Cell Line, Tumor Drug Tolerance Exotoxins - immunology Exotoxins - therapeutic use Gynecology. Andrology. Obstetrics Humans immunotherapy Immunotherapy - methods Immunotoxins - immunology Immunotoxins - therapeutic use Male Male genital diseases Medical sciences Mice Mice, SCID Nephrology. Urinary tract diseases prostate cancer Prostate-Specific Antigen - immunology Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Pseudomonas aeruginosa Exotoxin A Pseudomonas Exotoxin A PSMA recombinant immunotoxin Tumors Tumors of the urinary system Urinary tract. Prostate gland Virulence Factors - immunology Virulence Factors - therapeutic use Xenograft Model Antitumor Assays - methods
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