Dermcidin expression confers a survival advantage in prostate cancer cells subjected to oxidative stress or hypoxia

BACKGROUND Dermcidin (DCD) is a candidate survival gene in breast cancer. DCD gene expression has been identified in prostate cancer cell lines and primary prostate cancer tissue. The DCD protein is composed of proteolysis‐inducing factor‐core peptide (PIF‐CP) and the skin antimicrobial DCD‐1. The a...

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Veröffentlicht in:	The Prostate 2007-09, Vol.67 (12), p.1308-1317
Hauptverfasser:	Stewart, Grant D., Lowrie, Alastair G., Riddick, Antony C. P., Fearon, Kenneth C. H., Habib, Fouad K., Ross, James A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Death - genetics Cell Death - physiology Cell Hypoxia - physiology Cell Line, Tumor Cloning, Molecular dermcidin DNA, Neoplasm - chemistry DNA, Neoplasm - genetics Flow Cytometry Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics Humans hypoxia Immunohistochemistry Male Male genital diseases Medical sciences Mutagenesis, Site-Directed Nephrology. Urinary tract diseases Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics oxidative stress Oxidative Stress - physiology Peptides prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Neoplasm - genetics Statistics, Nonparametric survival Transfection Tumors Tumors of the urinary system Urinary tract. Prostate gland
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