Analysis of the MDM2 antagonist nutlin-3 in human prostate cancer cells

BACKGROUND Small molecule MDM2 antagonists including nutlin‐3 have been shown to be effective against a range of cancer cell types and nutlin‐3 can inhibit growth of LNCaP xenografts. We compared the efficacy of nutlin‐3 in three prostate cancer cell types and provide an insight into the mechanism o...

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Veröffentlicht in:	The Prostate 2007-06, Vol.67 (8), p.900-906
Hauptverfasser:	Logan, Ian R., McNeill, Hesta V., Cook, Susan, Lu, Xiaohong, Lunec, John, Robson, Craig N.
Format:	Artikel
Sprache:	eng
Schlagworte:	androgen receptor Apoptosis - drug effects Apoptosis - physiology Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Biological and medical sciences Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor Cell Proliferation - drug effects Gene Expression Regulation, Plant - drug effects Genes, p53 - drug effects Gynecology. Andrology. Obstetrics Humans Imidazoles - pharmacology Male Male genital diseases MDM2 Medical sciences Nephrology. Urinary tract diseases Nuclear Proteins - genetics Nuclear Proteins - metabolism nutlin-3 p53 Piperazines - pharmacology prostate cancer Prostate-Specific Antigen - genetics Prostate-Specific Antigen - metabolism Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors Proto-Oncogene Proteins c-mdm2 - metabolism Receptors, Androgen - genetics Receptors, Androgen - metabolism Signal Transduction - drug effects Signal Transduction - physiology Tumors Tumors of the urinary system Urinary tract. Prostate gland
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