Differential alterations in 5α-reductase type 1 and type 2 levels during development and progression of prostate cancer

BACKGROUND In the prostate, conversion of testosterone to dihydrotestosterone (DHT), by the enzymes 5α‐reductase types 1 and 2 (5αR1, 5αR2) is required for normal growth and probably also for development of prostate cancer (PCa). Finasteride, a 5αR2 inhibitor, was shown to reduce the prevalence of P...

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Veröffentlicht in:	The Prostate 2005-05, Vol.63 (3), p.231-239
Hauptverfasser:	Thomas, Lynn N., Lazier, C.B., Gupta, R., Norman, R.W., Troyer, D.A., O'Brien, S.P., Rittmaster, R.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	5α-reductase inhibitors androgens BPH immunohistochemistry PIN
Online-Zugang:	Volltext
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