Association of CYP17, GSTP1, and PON1 polymorphisms with the risk of prostate cancer
BACKGROUND Dietary factors, life‐style as well as environmental conditions may contribute to the risk of prostate tumor together with genetic susceptibility, that may be an important factor in determining who is more likely to develop prostate malignancy. We have undertaken a case‐control study in o...
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| Veröffentlicht in: | The Prostate 2005-05, Vol.63 (3), p.240-251 |
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| container_title | The Prostate |
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| creator | Antognelli, Cinzia Mearini, Luigi Talesa, Vincenzo Nicola Giannantoni, Antonella Mearini, Ettore |
| description | BACKGROUND
Dietary factors, life‐style as well as environmental conditions may contribute to the risk of prostate tumor together with genetic susceptibility, that may be an important factor in determining who is more likely to develop prostate malignancy. We have undertaken a case‐control study in order to elucidate the association between polymorphisms in some metabolizing genes with the risk of prostate cancer (PCa).
METHODS
Polymorphisms of three xenobiotic genes (CYP17, GSTP1, PON1) were characterized in 384 patients with untreated PCa and 360 age‐matched control patients with benign prostatic hyperplasia (BPH). All polymorphisms were investigated by PCR/RFLP methods using DNA from lymphocytes.
RESULTS
We found that men with the CYP17/A1A1–A1A2 genotypes, GSTP1/IleVal genotype, PON192/QR and PON55/LM–MM genotypes had a significantly higher risk of PCa compared with the others genotypes.
CONCLUSIONS
The three polymorphisms appear to be common genetic traits that are associated with an increased risk for PCa: the analysis of them all in each single case may be a predictable factor, particularly among groups exposed to PCa‐related carcinogens. © 2004 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/pros.20184 |
| format | Article |
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Dietary factors, life‐style as well as environmental conditions may contribute to the risk of prostate tumor together with genetic susceptibility, that may be an important factor in determining who is more likely to develop prostate malignancy. We have undertaken a case‐control study in order to elucidate the association between polymorphisms in some metabolizing genes with the risk of prostate cancer (PCa).
METHODS
Polymorphisms of three xenobiotic genes (CYP17, GSTP1, PON1) were characterized in 384 patients with untreated PCa and 360 age‐matched control patients with benign prostatic hyperplasia (BPH). All polymorphisms were investigated by PCR/RFLP methods using DNA from lymphocytes.
RESULTS
We found that men with the CYP17/A1A1–A1A2 genotypes, GSTP1/IleVal genotype, PON192/QR and PON55/LM–MM genotypes had a significantly higher risk of PCa compared with the others genotypes.
CONCLUSIONS
The three polymorphisms appear to be common genetic traits that are associated with an increased risk for PCa: the analysis of them all in each single case may be a predictable factor, particularly among groups exposed to PCa‐related carcinogens. © 2004 Wiley‐Liss, Inc.</description><identifier>ISSN: 0270-4137</identifier><identifier>EISSN: 1097-0045</identifier><identifier>DOI: 10.1002/pros.20184</identifier><identifier>PMID: 15538743</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Alleles ; Aryldialkylphosphatase - genetics ; CYP17 ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Glutathione S-Transferase pi ; Glutathione Transferase - genetics ; GSTP1 ; Homozygote ; Humans ; Isoenzymes - genetics ; Male ; metabolizing genes ; Middle Aged ; Odds Ratio ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; polymorphisms ; PON1 ; prostate cancer ; Prostate-Specific Antigen - blood ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - genetics ; Steroid 17-alpha-Hydroxylase - genetics</subject><ispartof>The Prostate, 2005-05, Vol.63 (3), p.240-251</ispartof><rights>Copyright © 2004 Wiley‐Liss, Inc.</rights><rights>(c) 2004 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3654-a6b782ee222a7aa1b3af04147d1d846e6ffa37e6fca0d114b50907cec17d65bf3</citedby><cites>FETCH-LOGICAL-c3654-a6b782ee222a7aa1b3af04147d1d846e6ffa37e6fca0d114b50907cec17d65bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpros.20184$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpros.20184$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15538743$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Antognelli, Cinzia</creatorcontrib><creatorcontrib>Mearini, Luigi</creatorcontrib><creatorcontrib>Talesa, Vincenzo Nicola</creatorcontrib><creatorcontrib>Giannantoni, Antonella</creatorcontrib><creatorcontrib>Mearini, Ettore</creatorcontrib><title>Association of CYP17, GSTP1, and PON1 polymorphisms with the risk of prostate cancer</title><title>The Prostate</title><addtitle>Prostate</addtitle><description>BACKGROUND
Dietary factors, life‐style as well as environmental conditions may contribute to the risk of prostate tumor together with genetic susceptibility, that may be an important factor in determining who is more likely to develop prostate malignancy. We have undertaken a case‐control study in order to elucidate the association between polymorphisms in some metabolizing genes with the risk of prostate cancer (PCa).
METHODS
Polymorphisms of three xenobiotic genes (CYP17, GSTP1, PON1) were characterized in 384 patients with untreated PCa and 360 age‐matched control patients with benign prostatic hyperplasia (BPH). All polymorphisms were investigated by PCR/RFLP methods using DNA from lymphocytes.
RESULTS
We found that men with the CYP17/A1A1–A1A2 genotypes, GSTP1/IleVal genotype, PON192/QR and PON55/LM–MM genotypes had a significantly higher risk of PCa compared with the others genotypes.
CONCLUSIONS
The three polymorphisms appear to be common genetic traits that are associated with an increased risk for PCa: the analysis of them all in each single case may be a predictable factor, particularly among groups exposed to PCa‐related carcinogens. © 2004 Wiley‐Liss, Inc.</description><subject>Aged</subject><subject>Alleles</subject><subject>Aryldialkylphosphatase - genetics</subject><subject>CYP17</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Glutathione S-Transferase pi</subject><subject>Glutathione Transferase - genetics</subject><subject>GSTP1</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Isoenzymes - genetics</subject><subject>Male</subject><subject>metabolizing genes</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>polymorphisms</subject><subject>PON1</subject><subject>prostate cancer</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Steroid 17-alpha-Hydroxylase - genetics</subject><issn>0270-4137</issn><issn>1097-0045</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9PwjAYxhujEUQvfgDTs2H4vm23siMhihoCi8wYvTTd1oUJY8s6g3x7h0O9eXouv-dPHkIuEQYIwG7KqrADBjgUR6SL4EsHQLjHpAtMgiOQyw45s_YdoMGBnZIOui4fSsG7JBxZW8SZrrNiQ4uUjl8DlH06WYQB9qneJDSYz5CWxXqXF1W5zGxu6Tarl7ReGlpldrV37RfUujY01pvYVOfkJNVray4O2iPPd7fh-N6ZzicP49HUibnnCkd7kRwyYxhjWmqNEdcpCBQywWQoPOOlqeaykVhDgigiF3yQsYlRJp4bpbxHrtvcuOm3lUlVWWW5rnYKQe2vUfth6vuaBr5q4fIjyk3yhx6-aABsgW22Nrt_olTwNF_8hDqtJ7O1-fz16GqlPMmlq15mExXOHkPw33zF-BeiQ30B</recordid><startdate>20050515</startdate><enddate>20050515</enddate><creator>Antognelli, Cinzia</creator><creator>Mearini, Luigi</creator><creator>Talesa, Vincenzo Nicola</creator><creator>Giannantoni, Antonella</creator><creator>Mearini, Ettore</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20050515</creationdate><title>Association of CYP17, GSTP1, and PON1 polymorphisms with the risk of prostate cancer</title><author>Antognelli, Cinzia ; Mearini, Luigi ; Talesa, Vincenzo Nicola ; Giannantoni, Antonella ; Mearini, Ettore</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3654-a6b782ee222a7aa1b3af04147d1d846e6ffa37e6fca0d114b50907cec17d65bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Alleles</topic><topic>Aryldialkylphosphatase - genetics</topic><topic>CYP17</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Glutathione S-Transferase pi</topic><topic>Glutathione Transferase - genetics</topic><topic>GSTP1</topic><topic>Homozygote</topic><topic>Humans</topic><topic>Isoenzymes - genetics</topic><topic>Male</topic><topic>metabolizing genes</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>polymorphisms</topic><topic>PON1</topic><topic>prostate cancer</topic><topic>Prostate-Specific Antigen - blood</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Steroid 17-alpha-Hydroxylase - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Antognelli, Cinzia</creatorcontrib><creatorcontrib>Mearini, Luigi</creatorcontrib><creatorcontrib>Talesa, Vincenzo Nicola</creatorcontrib><creatorcontrib>Giannantoni, Antonella</creatorcontrib><creatorcontrib>Mearini, Ettore</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The Prostate</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Antognelli, Cinzia</au><au>Mearini, Luigi</au><au>Talesa, Vincenzo Nicola</au><au>Giannantoni, Antonella</au><au>Mearini, Ettore</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of CYP17, GSTP1, and PON1 polymorphisms with the risk of prostate cancer</atitle><jtitle>The Prostate</jtitle><addtitle>Prostate</addtitle><date>2005-05-15</date><risdate>2005</risdate><volume>63</volume><issue>3</issue><spage>240</spage><epage>251</epage><pages>240-251</pages><issn>0270-4137</issn><eissn>1097-0045</eissn><abstract>BACKGROUND
Dietary factors, life‐style as well as environmental conditions may contribute to the risk of prostate tumor together with genetic susceptibility, that may be an important factor in determining who is more likely to develop prostate malignancy. We have undertaken a case‐control study in order to elucidate the association between polymorphisms in some metabolizing genes with the risk of prostate cancer (PCa).
METHODS
Polymorphisms of three xenobiotic genes (CYP17, GSTP1, PON1) were characterized in 384 patients with untreated PCa and 360 age‐matched control patients with benign prostatic hyperplasia (BPH). All polymorphisms were investigated by PCR/RFLP methods using DNA from lymphocytes.
RESULTS
We found that men with the CYP17/A1A1–A1A2 genotypes, GSTP1/IleVal genotype, PON192/QR and PON55/LM–MM genotypes had a significantly higher risk of PCa compared with the others genotypes.
CONCLUSIONS
The three polymorphisms appear to be common genetic traits that are associated with an increased risk for PCa: the analysis of them all in each single case may be a predictable factor, particularly among groups exposed to PCa‐related carcinogens. © 2004 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15538743</pmid><doi>10.1002/pros.20184</doi><tpages>12</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Aged Alleles Aryldialkylphosphatase - genetics CYP17 Gene Frequency Genetic Predisposition to Disease Genotype Glutathione S-Transferase pi Glutathione Transferase - genetics GSTP1 Homozygote Humans Isoenzymes - genetics Male metabolizing genes Middle Aged Odds Ratio Polymerase Chain Reaction Polymorphism, Genetic Polymorphism, Restriction Fragment Length polymorphisms PON1 prostate cancer Prostate-Specific Antigen - blood Prostatic Neoplasms - blood Prostatic Neoplasms - genetics Steroid 17-alpha-Hydroxylase - genetics |
| title | Association of CYP17, GSTP1, and PON1 polymorphisms with the risk of prostate cancer |
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