Associations of PM 2.5 exposure with emergency department visits and readmissions among preterm infants with bronchopulmonary dysplasia
To quantify the association of ambient air pollution (particulate matter, PM ) exposure with medically attended acute respiratory illness among infants with bronchopulmonary dysplasia (BPD). Single center, retrospective cohort study of preterm infants with BPD in Metropolitan Philadelphia. Multivari...
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Veröffentlicht in: | Pediatric pulmonology 2024-11, Vol.59 (11), p.2947-2955 |
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creator | Nelin, Timothy D Radack, Joshua K Yang, Nancy Lorch, Scott A DeMauro, Sara B Bamat, Nicolas A Jensen, Erik A Gibbs, Kathleen Murosko, Daria C Scott, Kristan A Goldstein, Nicolas P Novick Just, Allan C Burris, Heather H |
description | To quantify the association of ambient air pollution (particulate matter, PM
) exposure with medically attended acute respiratory illness among infants with bronchopulmonary dysplasia (BPD).
Single center, retrospective cohort study of preterm infants with BPD in Metropolitan Philadelphia. Multivariable logistic regression quantified associations of annual mean PM
exposure (per μg/m
) at the census block group level with medically attended acute respiratory illness, defined as emergency department (ED) visits or hospital readmissions within a year after first hospital discharge adjusting for age at neonatal intensive care unit (NICU) discharge, year, sex, race, insurance, BPD severity, and census tract deprivation. As a secondary analysis, we examined whether BPD severity modified the associations.
Of the 378 infants included in the analysis, 189 were non-Hispanic Black and 235 were publicly insured. Census block PM
level was not significantly associated with medically attended acute respiratory illnesses, ED visits, or hospital readmissions in the full study cohort. We observed significant effect modification by BPD grade; each 1 µg/m
higher annual PM
exposure was medically attended acute respiratory illness (adjusted odds ratio [aOR] 1.65, 95% CI: 1.06-2.63) among infants with Grade 1 BPD but not among infants with grade 3 BPD (aOR 0.83, 95% CI: 0.47-1.48) (interaction p = .024).
Cumulative PM
exposure in the year after NICU discharge was not significantly associated with medically attended acute respiratory illness among infants with BPD. However, infants with Grade 1 BPD had significantly higher odds with higher exposures. If replicated, these findings could inform anticipatory guidance for families of these infants to avoid outdoor activities during high pollution days after NICU discharge. |
doi_str_mv | 10.1002/ppul.27164 |
format | Article |
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) exposure with medically attended acute respiratory illness among infants with bronchopulmonary dysplasia (BPD).
Single center, retrospective cohort study of preterm infants with BPD in Metropolitan Philadelphia. Multivariable logistic regression quantified associations of annual mean PM
exposure (per μg/m
) at the census block group level with medically attended acute respiratory illness, defined as emergency department (ED) visits or hospital readmissions within a year after first hospital discharge adjusting for age at neonatal intensive care unit (NICU) discharge, year, sex, race, insurance, BPD severity, and census tract deprivation. As a secondary analysis, we examined whether BPD severity modified the associations.
Of the 378 infants included in the analysis, 189 were non-Hispanic Black and 235 were publicly insured. Census block PM
level was not significantly associated with medically attended acute respiratory illnesses, ED visits, or hospital readmissions in the full study cohort. We observed significant effect modification by BPD grade; each 1 µg/m
higher annual PM
exposure was medically attended acute respiratory illness (adjusted odds ratio [aOR] 1.65, 95% CI: 1.06-2.63) among infants with Grade 1 BPD but not among infants with grade 3 BPD (aOR 0.83, 95% CI: 0.47-1.48) (interaction p = .024).
Cumulative PM
exposure in the year after NICU discharge was not significantly associated with medically attended acute respiratory illness among infants with BPD. However, infants with Grade 1 BPD had significantly higher odds with higher exposures. If replicated, these findings could inform anticipatory guidance for families of these infants to avoid outdoor activities during high pollution days after NICU discharge.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.27164</identifier><identifier>PMID: 38958238</identifier><language>eng</language><publisher>United States</publisher><subject>Air Pollution - adverse effects ; Air Pollution - statistics & numerical data ; Bronchopulmonary Dysplasia - epidemiology ; Emergency Room Visits ; Emergency Service, Hospital - statistics & numerical data ; Environmental Exposure - adverse effects ; Environmental Exposure - statistics & numerical data ; Female ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Intensive Care Units, Neonatal - statistics & numerical data ; Male ; Particulate Matter - analysis ; Patient Readmission - statistics & numerical data ; Philadelphia - epidemiology ; Retrospective Studies</subject><ispartof>Pediatric pulmonology, 2024-11, Vol.59 (11), p.2947-2955</ispartof><rights>2024 The Author(s). Pediatric Pulmonology published by Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c588-c52d73e3ebf1df76fac7cdba4d9c81b33c99ff9bb7288eb57386d6a66f31ae1e3</cites><orcidid>0000-0002-5463-379X ; 0000-0003-1891-0101 ; 0000-0002-7435-2610</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38958238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nelin, Timothy D</creatorcontrib><creatorcontrib>Radack, Joshua K</creatorcontrib><creatorcontrib>Yang, Nancy</creatorcontrib><creatorcontrib>Lorch, Scott A</creatorcontrib><creatorcontrib>DeMauro, Sara B</creatorcontrib><creatorcontrib>Bamat, Nicolas A</creatorcontrib><creatorcontrib>Jensen, Erik A</creatorcontrib><creatorcontrib>Gibbs, Kathleen</creatorcontrib><creatorcontrib>Murosko, Daria C</creatorcontrib><creatorcontrib>Scott, Kristan A</creatorcontrib><creatorcontrib>Goldstein, Nicolas P Novick</creatorcontrib><creatorcontrib>Just, Allan C</creatorcontrib><creatorcontrib>Burris, Heather H</creatorcontrib><title>Associations of PM 2.5 exposure with emergency department visits and readmissions among preterm infants with bronchopulmonary dysplasia</title><title>Pediatric pulmonology</title><addtitle>Pediatr Pulmonol</addtitle><description>To quantify the association of ambient air pollution (particulate matter, PM
) exposure with medically attended acute respiratory illness among infants with bronchopulmonary dysplasia (BPD).
Single center, retrospective cohort study of preterm infants with BPD in Metropolitan Philadelphia. Multivariable logistic regression quantified associations of annual mean PM
exposure (per μg/m
) at the census block group level with medically attended acute respiratory illness, defined as emergency department (ED) visits or hospital readmissions within a year after first hospital discharge adjusting for age at neonatal intensive care unit (NICU) discharge, year, sex, race, insurance, BPD severity, and census tract deprivation. As a secondary analysis, we examined whether BPD severity modified the associations.
Of the 378 infants included in the analysis, 189 were non-Hispanic Black and 235 were publicly insured. Census block PM
level was not significantly associated with medically attended acute respiratory illnesses, ED visits, or hospital readmissions in the full study cohort. We observed significant effect modification by BPD grade; each 1 µg/m
higher annual PM
exposure was medically attended acute respiratory illness (adjusted odds ratio [aOR] 1.65, 95% CI: 1.06-2.63) among infants with Grade 1 BPD but not among infants with grade 3 BPD (aOR 0.83, 95% CI: 0.47-1.48) (interaction p = .024).
Cumulative PM
exposure in the year after NICU discharge was not significantly associated with medically attended acute respiratory illness among infants with BPD. However, infants with Grade 1 BPD had significantly higher odds with higher exposures. If replicated, these findings could inform anticipatory guidance for families of these infants to avoid outdoor activities during high pollution days after NICU discharge.</description><subject>Air Pollution - adverse effects</subject><subject>Air Pollution - statistics & numerical data</subject><subject>Bronchopulmonary Dysplasia - epidemiology</subject><subject>Emergency Room Visits</subject><subject>Emergency Service, Hospital - statistics & numerical data</subject><subject>Environmental Exposure - adverse effects</subject><subject>Environmental Exposure - statistics & numerical data</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Intensive Care Units, Neonatal - statistics & numerical data</subject><subject>Male</subject><subject>Particulate Matter - analysis</subject><subject>Patient Readmission - statistics & numerical data</subject><subject>Philadelphia - epidemiology</subject><subject>Retrospective Studies</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOAjEUQBujEUQ3foDp2gRsp0ynXRLiK8Hogv2kj1uoYaaTdlD5An_bAurm3sU9Obk5CF1TMqGEFHddt91Miory6QkaUiLlmEwlP0VDUZXlmAvOBugipXdC8k3SczRgQpaiYGKIvmcpBeNV70ObcHD47QUXkxLDVxfSNgL-9P0aQwNxBa3ZYQudin0DbY8_fPJ9wqq1OIKyjU_pIFFNaFe4i9BDbLBvnWozdvDoGFqzDvnfzKiYdbvUbVTy6hKdObVJcPW7R2j5cL-cP40Xr4_P89libEoh8ihsxYCBdtS6ijtlKmO1mlppBNWMGSmdk1pXhRCgy4oJbrni3DGqgAIboduj1sSQUgRXd9E3-ZOaknofs97HrA8xM3xzhLutbsD-o3_12A9GWHWH</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Nelin, Timothy D</creator><creator>Radack, Joshua K</creator><creator>Yang, Nancy</creator><creator>Lorch, Scott A</creator><creator>DeMauro, Sara B</creator><creator>Bamat, Nicolas A</creator><creator>Jensen, Erik A</creator><creator>Gibbs, Kathleen</creator><creator>Murosko, Daria C</creator><creator>Scott, Kristan A</creator><creator>Goldstein, Nicolas P Novick</creator><creator>Just, Allan C</creator><creator>Burris, Heather H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-5463-379X</orcidid><orcidid>https://orcid.org/0000-0003-1891-0101</orcidid><orcidid>https://orcid.org/0000-0002-7435-2610</orcidid></search><sort><creationdate>202411</creationdate><title>Associations of PM 2.5 exposure with emergency department visits and readmissions among preterm infants with bronchopulmonary dysplasia</title><author>Nelin, Timothy D ; Radack, Joshua K ; Yang, Nancy ; Lorch, Scott A ; DeMauro, Sara B ; Bamat, Nicolas A ; Jensen, Erik A ; Gibbs, Kathleen ; Murosko, Daria C ; Scott, Kristan A ; Goldstein, Nicolas P Novick ; Just, Allan C ; Burris, Heather H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c588-c52d73e3ebf1df76fac7cdba4d9c81b33c99ff9bb7288eb57386d6a66f31ae1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Air Pollution - adverse effects</topic><topic>Air Pollution - statistics & numerical data</topic><topic>Bronchopulmonary Dysplasia - epidemiology</topic><topic>Emergency Room Visits</topic><topic>Emergency Service, Hospital - statistics & numerical data</topic><topic>Environmental Exposure - adverse effects</topic><topic>Environmental Exposure - statistics & numerical data</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Intensive Care Units, Neonatal - statistics & numerical data</topic><topic>Male</topic><topic>Particulate Matter - analysis</topic><topic>Patient Readmission - statistics & numerical data</topic><topic>Philadelphia - epidemiology</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nelin, Timothy D</creatorcontrib><creatorcontrib>Radack, Joshua K</creatorcontrib><creatorcontrib>Yang, Nancy</creatorcontrib><creatorcontrib>Lorch, Scott A</creatorcontrib><creatorcontrib>DeMauro, Sara B</creatorcontrib><creatorcontrib>Bamat, Nicolas A</creatorcontrib><creatorcontrib>Jensen, Erik A</creatorcontrib><creatorcontrib>Gibbs, Kathleen</creatorcontrib><creatorcontrib>Murosko, Daria C</creatorcontrib><creatorcontrib>Scott, Kristan A</creatorcontrib><creatorcontrib>Goldstein, Nicolas P Novick</creatorcontrib><creatorcontrib>Just, Allan C</creatorcontrib><creatorcontrib>Burris, Heather H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nelin, Timothy D</au><au>Radack, Joshua K</au><au>Yang, Nancy</au><au>Lorch, Scott A</au><au>DeMauro, Sara B</au><au>Bamat, Nicolas A</au><au>Jensen, Erik A</au><au>Gibbs, Kathleen</au><au>Murosko, Daria C</au><au>Scott, Kristan A</au><au>Goldstein, Nicolas P Novick</au><au>Just, Allan C</au><au>Burris, Heather H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of PM 2.5 exposure with emergency department visits and readmissions among preterm infants with bronchopulmonary dysplasia</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr Pulmonol</addtitle><date>2024-11</date><risdate>2024</risdate><volume>59</volume><issue>11</issue><spage>2947</spage><epage>2955</epage><pages>2947-2955</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><abstract>To quantify the association of ambient air pollution (particulate matter, PM
) exposure with medically attended acute respiratory illness among infants with bronchopulmonary dysplasia (BPD).
Single center, retrospective cohort study of preterm infants with BPD in Metropolitan Philadelphia. Multivariable logistic regression quantified associations of annual mean PM
exposure (per μg/m
) at the census block group level with medically attended acute respiratory illness, defined as emergency department (ED) visits or hospital readmissions within a year after first hospital discharge adjusting for age at neonatal intensive care unit (NICU) discharge, year, sex, race, insurance, BPD severity, and census tract deprivation. As a secondary analysis, we examined whether BPD severity modified the associations.
Of the 378 infants included in the analysis, 189 were non-Hispanic Black and 235 were publicly insured. Census block PM
level was not significantly associated with medically attended acute respiratory illnesses, ED visits, or hospital readmissions in the full study cohort. We observed significant effect modification by BPD grade; each 1 µg/m
higher annual PM
exposure was medically attended acute respiratory illness (adjusted odds ratio [aOR] 1.65, 95% CI: 1.06-2.63) among infants with Grade 1 BPD but not among infants with grade 3 BPD (aOR 0.83, 95% CI: 0.47-1.48) (interaction p = .024).
Cumulative PM
exposure in the year after NICU discharge was not significantly associated with medically attended acute respiratory illness among infants with BPD. However, infants with Grade 1 BPD had significantly higher odds with higher exposures. If replicated, these findings could inform anticipatory guidance for families of these infants to avoid outdoor activities during high pollution days after NICU discharge.</abstract><cop>United States</cop><pmid>38958238</pmid><doi>10.1002/ppul.27164</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5463-379X</orcidid><orcidid>https://orcid.org/0000-0003-1891-0101</orcidid><orcidid>https://orcid.org/0000-0002-7435-2610</orcidid></addata></record> |
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subjects | Air Pollution - adverse effects Air Pollution - statistics & numerical data Bronchopulmonary Dysplasia - epidemiology Emergency Room Visits Emergency Service, Hospital - statistics & numerical data Environmental Exposure - adverse effects Environmental Exposure - statistics & numerical data Female Humans Infant Infant, Newborn Infant, Premature Intensive Care Units, Neonatal - statistics & numerical data Male Particulate Matter - analysis Patient Readmission - statistics & numerical data Philadelphia - epidemiology Retrospective Studies |
title | Associations of PM 2.5 exposure with emergency department visits and readmissions among preterm infants with bronchopulmonary dysplasia |
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