Follow-up of compliance with tuberculosis treatment in children: Monitoring by urine tests
This study was designed to follow up patient compliance by detection of antituberculous drugsx in urine during the course of treatment. It was conducted in the Outpatient Clinic of Pediatric Infectious Diseases, Sisli Etfal Hospital (Istanbul, Turkey). In total, 45 children with pulmonary tuberculos...
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| Veröffentlicht in: | Pediatric pulmonology 2003-07, Vol.36 (1), p.55-57 |
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| creator | Palanduz, AyşE Gultekin, Derya Kayaalp, Nimet |
| description | This study was designed to follow up patient compliance by detection of antituberculous drugsx in urine during the course of treatment. It was conducted in the Outpatient Clinic of Pediatric Infectious Diseases, Sisli Etfal Hospital (Istanbul, Turkey). In total, 45 children with pulmonary tuberculosis participated. Patients were seen twice in the first month and once a month thereafter during the 6‐month course of treatment. The second urine of the day was collected at each visit. Urine was tested for isoniazid (INH), rifampicin (RIF), and pyrazinamide (PZA). In the presence of these drugs or their metabolites, the addition of certain chemicals caused a color change in the urine. On day 15 of treatment, urine tested positive for INH in 82% of patients, for RIF in 67%, and for PZA in 73%. At the end of the second month, the ratio of adherence was 96, 89, and 96% for each drug, respectively. All patients were found to be adherent at months 5 and 6. We recommend detection of antituberculous drugs in urine to assess compliance to treatment. Once the defaulting patients were identified, adherence was improved by repeatedly providing patient education throughout the treatment. Pediatr Pulmonol. 2003; 36:55–57. © 2003 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ppul.10314 |
| format | Article |
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It was conducted in the Outpatient Clinic of Pediatric Infectious Diseases, Sisli Etfal Hospital (Istanbul, Turkey). In total, 45 children with pulmonary tuberculosis participated. Patients were seen twice in the first month and once a month thereafter during the 6‐month course of treatment. The second urine of the day was collected at each visit. Urine was tested for isoniazid (INH), rifampicin (RIF), and pyrazinamide (PZA). In the presence of these drugs or their metabolites, the addition of certain chemicals caused a color change in the urine. On day 15 of treatment, urine tested positive for INH in 82% of patients, for RIF in 67%, and for PZA in 73%. At the end of the second month, the ratio of adherence was 96, 89, and 96% for each drug, respectively. All patients were found to be adherent at months 5 and 6. We recommend detection of antituberculous drugs in urine to assess compliance to treatment. Once the defaulting patients were identified, adherence was improved by repeatedly providing patient education throughout the treatment. Pediatr Pulmonol. 2003; 36:55–57. © 2003 Wiley‐Liss, Inc.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.10314</identifier><identifier>PMID: 12772224</identifier><identifier>CODEN: PEPUES</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antitubercular Agents - administration & dosage ; Biological and medical sciences ; Child ; Child, Preschool ; compliance ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Follow-Up Studies ; Humans ; isoniazid ; Isoniazid - administration & dosage ; Isoniazid - metabolism ; Male ; Medical sciences ; Monitoring, Physiologic - methods ; Patient Compliance - statistics & numerical data ; Pharmacology. Drug treatments ; Prospective Studies ; pyrazinamide ; Pyrazinamide - administration & dosage ; Pyrazinamide - metabolism ; rifampicin ; Rifampin - administration & dosage ; Rifampin - metabolism ; Sensitivity and Specificity ; Treatment Outcome ; tuberculosis ; Tuberculosis, Pulmonary - diagnosis ; Tuberculosis, Pulmonary - drug therapy ; Turkey ; Urinalysis - methods ; Urine - chemistry ; urine testing</subject><ispartof>Pediatric pulmonology, 2003-07, Vol.36 (1), p.55-57</ispartof><rights>Copyright © 2003 Wiley‐Liss, Inc.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3624-cdf7e9346c29776bffaa3003487ba2b7b7039eb4872cc74ecb0f508eecce05ef3</citedby><cites>FETCH-LOGICAL-c3624-cdf7e9346c29776bffaa3003487ba2b7b7039eb4872cc74ecb0f508eecce05ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fppul.10314$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fppul.10314$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14893254$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12772224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Palanduz, AyşE</creatorcontrib><creatorcontrib>Gultekin, Derya</creatorcontrib><creatorcontrib>Kayaalp, Nimet</creatorcontrib><title>Follow-up of compliance with tuberculosis treatment in children: Monitoring by urine tests</title><title>Pediatric pulmonology</title><addtitle>Pediatr. Pulmonol</addtitle><description>This study was designed to follow up patient compliance by detection of antituberculous drugsx in urine during the course of treatment. It was conducted in the Outpatient Clinic of Pediatric Infectious Diseases, Sisli Etfal Hospital (Istanbul, Turkey). In total, 45 children with pulmonary tuberculosis participated. Patients were seen twice in the first month and once a month thereafter during the 6‐month course of treatment. The second urine of the day was collected at each visit. Urine was tested for isoniazid (INH), rifampicin (RIF), and pyrazinamide (PZA). In the presence of these drugs or their metabolites, the addition of certain chemicals caused a color change in the urine. On day 15 of treatment, urine tested positive for INH in 82% of patients, for RIF in 67%, and for PZA in 73%. At the end of the second month, the ratio of adherence was 96, 89, and 96% for each drug, respectively. All patients were found to be adherent at months 5 and 6. We recommend detection of antituberculous drugs in urine to assess compliance to treatment. Once the defaulting patients were identified, adherence was improved by repeatedly providing patient education throughout the treatment. Pediatr Pulmonol. 2003; 36:55–57. © 2003 Wiley‐Liss, Inc.</description><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antitubercular Agents - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>compliance</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>isoniazid</subject><subject>Isoniazid - administration & dosage</subject><subject>Isoniazid - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Monitoring, Physiologic - methods</subject><subject>Patient Compliance - statistics & numerical data</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>pyrazinamide</subject><subject>Pyrazinamide - administration & dosage</subject><subject>Pyrazinamide - metabolism</subject><subject>rifampicin</subject><subject>Rifampin - administration & dosage</subject><subject>Rifampin - metabolism</subject><subject>Sensitivity and Specificity</subject><subject>Treatment Outcome</subject><subject>tuberculosis</subject><subject>Tuberculosis, Pulmonary - diagnosis</subject><subject>Tuberculosis, Pulmonary - drug therapy</subject><subject>Turkey</subject><subject>Urinalysis - methods</subject><subject>Urine - chemistry</subject><subject>urine testing</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EgvKx8AOQFxakgGMnccIGiC9RSgcQEotlu2cwuElkOyr996S0wMZ07-meu5MehPZTcpwSQk_atnN9Ymm2hgYpqaqEZFWxjgYlz_OkKAu2hbZDeCekn1XpJtpKKeeU0myAXq4a55pZ0rW4MVg309ZZWWvAMxvfcOwUeN25JtiAowcZp1BHbGus36ybeKhP8X1T29h4W79iNcddHwBHCDHsog0jXYC9Vd1BT1eXjxc3yfDh-vbibJhoVtAs0RPDoWJZoWnFeaGMkZIRwrKSK0kVV5ywClTfUq15BloRk5MSQGsgORi2g46Wd7VvQvBgROvtVPq5SIlYCBILQeJbUA8fLOG2U1OY_KErIz1wuAJk0NIZ39uw4Y_LyorRfMGlS25mHcz_eSnG46fhz_NkuWNDhM_fHek_RMEZz8Xz6FrcPZZ3PD8fihH7Ar6ljvw</recordid><startdate>200307</startdate><enddate>200307</enddate><creator>Palanduz, AyşE</creator><creator>Gultekin, Derya</creator><creator>Kayaalp, Nimet</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200307</creationdate><title>Follow-up of compliance with tuberculosis treatment in children: Monitoring by urine tests</title><author>Palanduz, AyşE ; Gultekin, Derya ; Kayaalp, Nimet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3624-cdf7e9346c29776bffaa3003487ba2b7b7039eb4872cc74ecb0f508eecce05ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antitubercular Agents - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>compliance</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>isoniazid</topic><topic>Isoniazid - administration & dosage</topic><topic>Isoniazid - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Monitoring, Physiologic - methods</topic><topic>Patient Compliance - statistics & numerical data</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>pyrazinamide</topic><topic>Pyrazinamide - administration & dosage</topic><topic>Pyrazinamide - metabolism</topic><topic>rifampicin</topic><topic>Rifampin - administration & dosage</topic><topic>Rifampin - metabolism</topic><topic>Sensitivity and Specificity</topic><topic>Treatment Outcome</topic><topic>tuberculosis</topic><topic>Tuberculosis, Pulmonary - diagnosis</topic><topic>Tuberculosis, Pulmonary - drug therapy</topic><topic>Turkey</topic><topic>Urinalysis - methods</topic><topic>Urine - chemistry</topic><topic>urine testing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Palanduz, AyşE</creatorcontrib><creatorcontrib>Gultekin, Derya</creatorcontrib><creatorcontrib>Kayaalp, Nimet</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Palanduz, AyşE</au><au>Gultekin, Derya</au><au>Kayaalp, Nimet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Follow-up of compliance with tuberculosis treatment in children: Monitoring by urine tests</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr. Pulmonol</addtitle><date>2003-07</date><risdate>2003</risdate><volume>36</volume><issue>1</issue><spage>55</spage><epage>57</epage><pages>55-57</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><coden>PEPUES</coden><abstract>This study was designed to follow up patient compliance by detection of antituberculous drugsx in urine during the course of treatment. It was conducted in the Outpatient Clinic of Pediatric Infectious Diseases, Sisli Etfal Hospital (Istanbul, Turkey). In total, 45 children with pulmonary tuberculosis participated. Patients were seen twice in the first month and once a month thereafter during the 6‐month course of treatment. The second urine of the day was collected at each visit. Urine was tested for isoniazid (INH), rifampicin (RIF), and pyrazinamide (PZA). In the presence of these drugs or their metabolites, the addition of certain chemicals caused a color change in the urine. On day 15 of treatment, urine tested positive for INH in 82% of patients, for RIF in 67%, and for PZA in 73%. At the end of the second month, the ratio of adherence was 96, 89, and 96% for each drug, respectively. All patients were found to be adherent at months 5 and 6. We recommend detection of antituberculous drugs in urine to assess compliance to treatment. Once the defaulting patients were identified, adherence was improved by repeatedly providing patient education throughout the treatment. Pediatr Pulmonol. 2003; 36:55–57. © 2003 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12772224</pmid><doi>10.1002/ppul.10314</doi><tpages>3</tpages></addata></record> |
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| subjects | Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular Agents - administration & dosage Biological and medical sciences Child Child, Preschool compliance Dose-Response Relationship, Drug Drug Administration Schedule Female Follow-Up Studies Humans isoniazid Isoniazid - administration & dosage Isoniazid - metabolism Male Medical sciences Monitoring, Physiologic - methods Patient Compliance - statistics & numerical data Pharmacology. Drug treatments Prospective Studies pyrazinamide Pyrazinamide - administration & dosage Pyrazinamide - metabolism rifampicin Rifampin - administration & dosage Rifampin - metabolism Sensitivity and Specificity Treatment Outcome tuberculosis Tuberculosis, Pulmonary - diagnosis Tuberculosis, Pulmonary - drug therapy Turkey Urinalysis - methods Urine - chemistry urine testing |
| title | Follow-up of compliance with tuberculosis treatment in children: Monitoring by urine tests |
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