Preparation and characterization of poly(2-methacryloyloxyethyl phosphorylcholine)-block-poly(D,L-lactide) polymer nanoparticles
A poly(D,L‐lactide)–bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L‐lactide) and 2‐methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization....
Gespeichert in:
| Veröffentlicht in: | Journal of polymer science. Part A, Polymer chemistry Polymer chemistry, 2007-02, Vol.45 (4), p.688-698 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 698 |
|---|---|
| container_issue | 4 |
| container_start_page | 688 |
| container_title | Journal of polymer science. Part A, Polymer chemistry |
| container_volume | 45 |
| creator | Hsiue, Ging-Ho Lo, Chun-Liang Cheng, Ching-Hao Lin, Che-Ping Huang, Chun-Kai Chen, Hung-Hao |
| description | A poly(D,L‐lactide)–bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L‐lactide) and 2‐methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization. Polymeric nanoparticles were prepared by a dialysis process in a select solvent. The shape and structure of the polymeric nanoparticles were determined by 1H NMR, atomic force microscopy, and ζ‐potential measurements. The results of cytotoxicity tests showed the good cytocompatibility of the lipid‐like diblock copolymer poly(2‐methacryloyloxyethyl phosphorylcholine)‐block‐poly(D,L‐lactide). © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 688–698, 2007
A poly(D,L‐lactide)–bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L‐lactide) and 2‐methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization. Polymeric nanoparticles were prepared by a dialysis process in a select solvent. The shape and structure of the polymeric nanoparticles were determined by 1H NMR, atomic force microscopy, and ζ‐potential measurements. The results of cytotoxicity tests showed the good cytocompatibility of the lipid‐like diblock copolymer poly(2‐methacryloyloxyethyl phosphorylcholine)‐block‐poly(D,L‐lactide). |
| doi_str_mv | 10.1002/pola.21741 |
| format | Article |
| fullrecord | <record><control><sourceid>wiley_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1002_pola_21741</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>POLA21741</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4431-52a026e3a5e04892b2440624656618fb6975963931cf09b07af040c020a87a203</originalsourceid><addsrcrecordid>eNp9kEtP3TAQhS3USr2l3fQXZFOpVBjGTuLHEtHyvAIWrcrOmmscXRffOLIjlbDip2Nu-thVsmXN-JxvNIeQDwwOGAA_HGLAA85kw3bIgoHWFFqmXpEFKCWp4M3tG_I2558A5a9VC_J0k9yACUcf-wr7u8quS2VHl_zj3IxdVajTJ043blyjTVOI5TxMpZpCNaxjLrd07ToG37s9ugrR3tOt6cv-koaC83dub4vZuFT12Mcyc_Q2uPyOvO4wZPf-97tLvp98_XZ8RpfXp-fHR0tqm6ZmtOUIXLgaWweN0nzFmwbKPqIVgqluJbRstah1zWwHegUSO2jAAgdUEjnUu-TzzLUp5pxcZ4bkN5gmw8C8ZGdesjPb7Ir44yweMFsMXcLe-vzPoVrQXMqiY7Pulw9u-g_R3Fwvj_6w6ezxeXQPfz2Y7o2QtWzNj6tTA-ri8lLoM3NRPwPy44-Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Preparation and characterization of poly(2-methacryloyloxyethyl phosphorylcholine)-block-poly(D,L-lactide) polymer nanoparticles</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Hsiue, Ging-Ho ; Lo, Chun-Liang ; Cheng, Ching-Hao ; Lin, Che-Ping ; Huang, Chun-Kai ; Chen, Hung-Hao</creator><creatorcontrib>Hsiue, Ging-Ho ; Lo, Chun-Liang ; Cheng, Ching-Hao ; Lin, Che-Ping ; Huang, Chun-Kai ; Chen, Hung-Hao</creatorcontrib><description>A poly(D,L‐lactide)–bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L‐lactide) and 2‐methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization. Polymeric nanoparticles were prepared by a dialysis process in a select solvent. The shape and structure of the polymeric nanoparticles were determined by 1H NMR, atomic force microscopy, and ζ‐potential measurements. The results of cytotoxicity tests showed the good cytocompatibility of the lipid‐like diblock copolymer poly(2‐methacryloyloxyethyl phosphorylcholine)‐block‐poly(D,L‐lactide). © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 688–698, 2007
A poly(D,L‐lactide)–bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L‐lactide) and 2‐methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization. Polymeric nanoparticles were prepared by a dialysis process in a select solvent. The shape and structure of the polymeric nanoparticles were determined by 1H NMR, atomic force microscopy, and ζ‐potential measurements. The results of cytotoxicity tests showed the good cytocompatibility of the lipid‐like diblock copolymer poly(2‐methacryloyloxyethyl phosphorylcholine)‐block‐poly(D,L‐lactide).</description><identifier>ISSN: 0887-624X</identifier><identifier>EISSN: 1099-0518</identifier><identifier>DOI: 10.1002/pola.21741</identifier><identifier>CODEN: JPLCAT</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Applied sciences ; atom transfer radical polymerization (ATRP) ; diblock copolymers ; Exact sciences and technology ; L-lactide) (PLA ; nanoparticles ; Organic polymers ; Physicochemistry of polymers ; poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) ; poly(D ; poly(D,L‐lactide) (PLA) ; Polymers with particular properties ; Preparation, kinetics, thermodynamics, mechanism and catalysts</subject><ispartof>Journal of polymer science. Part A, Polymer chemistry, 2007-02, Vol.45 (4), p.688-698</ispartof><rights>Copyright © 2006 Wiley Periodicals, Inc.</rights><rights>2007 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4431-52a026e3a5e04892b2440624656618fb6975963931cf09b07af040c020a87a203</citedby><cites>FETCH-LOGICAL-c4431-52a026e3a5e04892b2440624656618fb6975963931cf09b07af040c020a87a203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpola.21741$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpola.21741$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18509277$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Hsiue, Ging-Ho</creatorcontrib><creatorcontrib>Lo, Chun-Liang</creatorcontrib><creatorcontrib>Cheng, Ching-Hao</creatorcontrib><creatorcontrib>Lin, Che-Ping</creatorcontrib><creatorcontrib>Huang, Chun-Kai</creatorcontrib><creatorcontrib>Chen, Hung-Hao</creatorcontrib><title>Preparation and characterization of poly(2-methacryloyloxyethyl phosphorylcholine)-block-poly(D,L-lactide) polymer nanoparticles</title><title>Journal of polymer science. Part A, Polymer chemistry</title><addtitle>J. Polym. Sci. A Polym. Chem</addtitle><description>A poly(D,L‐lactide)–bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L‐lactide) and 2‐methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization. Polymeric nanoparticles were prepared by a dialysis process in a select solvent. The shape and structure of the polymeric nanoparticles were determined by 1H NMR, atomic force microscopy, and ζ‐potential measurements. The results of cytotoxicity tests showed the good cytocompatibility of the lipid‐like diblock copolymer poly(2‐methacryloyloxyethyl phosphorylcholine)‐block‐poly(D,L‐lactide). © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 688–698, 2007
A poly(D,L‐lactide)–bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L‐lactide) and 2‐methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization. Polymeric nanoparticles were prepared by a dialysis process in a select solvent. The shape and structure of the polymeric nanoparticles were determined by 1H NMR, atomic force microscopy, and ζ‐potential measurements. The results of cytotoxicity tests showed the good cytocompatibility of the lipid‐like diblock copolymer poly(2‐methacryloyloxyethyl phosphorylcholine)‐block‐poly(D,L‐lactide).</description><subject>Applied sciences</subject><subject>atom transfer radical polymerization (ATRP)</subject><subject>diblock copolymers</subject><subject>Exact sciences and technology</subject><subject>L-lactide) (PLA</subject><subject>nanoparticles</subject><subject>Organic polymers</subject><subject>Physicochemistry of polymers</subject><subject>poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)</subject><subject>poly(D</subject><subject>poly(D,L‐lactide) (PLA)</subject><subject>Polymers with particular properties</subject><subject>Preparation, kinetics, thermodynamics, mechanism and catalysts</subject><issn>0887-624X</issn><issn>1099-0518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNp9kEtP3TAQhS3USr2l3fQXZFOpVBjGTuLHEtHyvAIWrcrOmmscXRffOLIjlbDip2Nu-thVsmXN-JxvNIeQDwwOGAA_HGLAA85kw3bIgoHWFFqmXpEFKCWp4M3tG_I2558A5a9VC_J0k9yACUcf-wr7u8quS2VHl_zj3IxdVajTJ043blyjTVOI5TxMpZpCNaxjLrd07ToG37s9ugrR3tOt6cv-koaC83dub4vZuFT12Mcyc_Q2uPyOvO4wZPf-97tLvp98_XZ8RpfXp-fHR0tqm6ZmtOUIXLgaWweN0nzFmwbKPqIVgqluJbRstah1zWwHegUSO2jAAgdUEjnUu-TzzLUp5pxcZ4bkN5gmw8C8ZGdesjPb7Ir44yweMFsMXcLe-vzPoVrQXMqiY7Pulw9u-g_R3Fwvj_6w6ezxeXQPfz2Y7o2QtWzNj6tTA-ri8lLoM3NRPwPy44-Q</recordid><startdate>20070215</startdate><enddate>20070215</enddate><creator>Hsiue, Ging-Ho</creator><creator>Lo, Chun-Liang</creator><creator>Cheng, Ching-Hao</creator><creator>Lin, Che-Ping</creator><creator>Huang, Chun-Kai</creator><creator>Chen, Hung-Hao</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20070215</creationdate><title>Preparation and characterization of poly(2-methacryloyloxyethyl phosphorylcholine)-block-poly(D,L-lactide) polymer nanoparticles</title><author>Hsiue, Ging-Ho ; Lo, Chun-Liang ; Cheng, Ching-Hao ; Lin, Che-Ping ; Huang, Chun-Kai ; Chen, Hung-Hao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4431-52a026e3a5e04892b2440624656618fb6975963931cf09b07af040c020a87a203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Applied sciences</topic><topic>atom transfer radical polymerization (ATRP)</topic><topic>diblock copolymers</topic><topic>Exact sciences and technology</topic><topic>L-lactide) (PLA</topic><topic>nanoparticles</topic><topic>Organic polymers</topic><topic>Physicochemistry of polymers</topic><topic>poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)</topic><topic>poly(D</topic><topic>poly(D,L‐lactide) (PLA)</topic><topic>Polymers with particular properties</topic><topic>Preparation, kinetics, thermodynamics, mechanism and catalysts</topic><toplevel>online_resources</toplevel><creatorcontrib>Hsiue, Ging-Ho</creatorcontrib><creatorcontrib>Lo, Chun-Liang</creatorcontrib><creatorcontrib>Cheng, Ching-Hao</creatorcontrib><creatorcontrib>Lin, Che-Ping</creatorcontrib><creatorcontrib>Huang, Chun-Kai</creatorcontrib><creatorcontrib>Chen, Hung-Hao</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Journal of polymer science. Part A, Polymer chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsiue, Ging-Ho</au><au>Lo, Chun-Liang</au><au>Cheng, Ching-Hao</au><au>Lin, Che-Ping</au><au>Huang, Chun-Kai</au><au>Chen, Hung-Hao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation and characterization of poly(2-methacryloyloxyethyl phosphorylcholine)-block-poly(D,L-lactide) polymer nanoparticles</atitle><jtitle>Journal of polymer science. Part A, Polymer chemistry</jtitle><addtitle>J. Polym. Sci. A Polym. Chem</addtitle><date>2007-02-15</date><risdate>2007</risdate><volume>45</volume><issue>4</issue><spage>688</spage><epage>698</epage><pages>688-698</pages><issn>0887-624X</issn><eissn>1099-0518</eissn><coden>JPLCAT</coden><abstract>A poly(D,L‐lactide)–bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L‐lactide) and 2‐methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization. Polymeric nanoparticles were prepared by a dialysis process in a select solvent. The shape and structure of the polymeric nanoparticles were determined by 1H NMR, atomic force microscopy, and ζ‐potential measurements. The results of cytotoxicity tests showed the good cytocompatibility of the lipid‐like diblock copolymer poly(2‐methacryloyloxyethyl phosphorylcholine)‐block‐poly(D,L‐lactide). © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 688–698, 2007
A poly(D,L‐lactide)–bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L‐lactide) and 2‐methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization. Polymeric nanoparticles were prepared by a dialysis process in a select solvent. The shape and structure of the polymeric nanoparticles were determined by 1H NMR, atomic force microscopy, and ζ‐potential measurements. The results of cytotoxicity tests showed the good cytocompatibility of the lipid‐like diblock copolymer poly(2‐methacryloyloxyethyl phosphorylcholine)‐block‐poly(D,L‐lactide).</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><doi>10.1002/pola.21741</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0887-624X |
| ispartof | Journal of polymer science. Part A, Polymer chemistry, 2007-02, Vol.45 (4), p.688-698 |
| issn | 0887-624X 1099-0518 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_pola_21741 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Applied sciences atom transfer radical polymerization (ATRP) diblock copolymers Exact sciences and technology L-lactide) (PLA nanoparticles Organic polymers Physicochemistry of polymers poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) poly(D poly(D,L‐lactide) (PLA) Polymers with particular properties Preparation, kinetics, thermodynamics, mechanism and catalysts |
| title | Preparation and characterization of poly(2-methacryloyloxyethyl phosphorylcholine)-block-poly(D,L-lactide) polymer nanoparticles |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T17%3A49%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wiley_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Preparation%20and%20characterization%20of%20poly(2-methacryloyloxyethyl%20phosphorylcholine)-block-poly(D,L-lactide)%20polymer%20nanoparticles&rft.jtitle=Journal%20of%20polymer%20science.%20Part%20A,%20Polymer%20chemistry&rft.au=Hsiue,%20Ging-Ho&rft.date=2007-02-15&rft.volume=45&rft.issue=4&rft.spage=688&rft.epage=698&rft.pages=688-698&rft.issn=0887-624X&rft.eissn=1099-0518&rft.coden=JPLCAT&rft_id=info:doi/10.1002/pola.21741&rft_dat=%3Cwiley_cross%3EPOLA21741%3C/wiley_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |