Durable complete response to chemotherapy in an infant with a clival chordoma
Chordomas are rare bone tumors of notochord remnants that may occur anywhere within the axial skeleton. The standard of care is complete surgical removal. Proton beam irradiation is commonly used when the tumor is inaccessible or has recurred. Chemotherapy has been used in the treatment of patients...
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| Veröffentlicht in: | Pediatric blood & cancer 2012-08, Vol.59 (2), p.323-325 |
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| container_title | Pediatric blood & cancer |
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| creator | Al-Rahawan, Mohamad M. Siebert, James D. Mitchell, Craig S. Smith, Stephen D. |
| description | Chordomas are rare bone tumors of notochord remnants that may occur anywhere within the axial skeleton. The standard of care is complete surgical removal. Proton beam irradiation is commonly used when the tumor is inaccessible or has recurred. Chemotherapy has been used in the treatment of patients at relapse but it has been generally proven ineffective. We report a 7‐month‐old infant with a clival chordoma who responded to combination chemotherapy consisting of cycles of vincristine/cyclophosphamide/doxorubicin alternating with etoposide/ifosfamide. She has been off chemotherapy for 2 years and is well at age 5. Pediatr Blood Cancer 2012;59:323–325. © 2011 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/pbc.23297 |
| format | Article |
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Blood Cancer</addtitle><description>Chordomas are rare bone tumors of notochord remnants that may occur anywhere within the axial skeleton. The standard of care is complete surgical removal. Proton beam irradiation is commonly used when the tumor is inaccessible or has recurred. Chemotherapy has been used in the treatment of patients at relapse but it has been generally proven ineffective. We report a 7‐month‐old infant with a clival chordoma who responded to combination chemotherapy consisting of cycles of vincristine/cyclophosphamide/doxorubicin alternating with etoposide/ifosfamide. She has been off chemotherapy for 2 years and is well at age 5. Pediatr Blood Cancer 2012;59:323–325. © 2011 Wiley Periodicals, Inc.</description><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Brain Mapping</subject><subject>chemotherapy</subject><subject>child</subject><subject>chordoma</subject><subject>Chordoma - diagnosis</subject><subject>Chordoma - drug therapy</subject><subject>clivus</subject><subject>Cyclophosphamide - administration & dosage</subject><subject>Doxorubicin - administration & dosage</subject><subject>Etoposide - administration & dosage</subject><subject>Humans</subject><subject>Ifosfamide - administration & dosage</subject><subject>Infant</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Remission Induction</subject><subject>Skull Base Neoplasms - diagnosis</subject><subject>Skull Base Neoplasms - drug therapy</subject><subject>Vincristine - administration & dosage</subject><issn>1545-5009</issn><issn>1545-5017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAUhS0EoqUw8AeQV4a0fsR2MkKgBak8BhCj5fihBvKSnVL67wmEdmO55w7fOcMHwDlGU4wQmbW5nhJKUnEAxpjFLGIIi8P9j9IROAnhvUc5YskxGBGcEsLjeAwebtZe5aWFuqna0nYWehvapg4Wdg3UK1s13cp61W5hUUNV99epuoOboltBBXVZfKqy5xpvmkqdgiOnymDP_nICXue3L9ldtHxa3GdXy0hTikQksFDOWeW4SzUzRuWIJpRohoXhJmEk5VYzRnPGMHE2jjHT2iiecMpiwxGdgMthV_smBG-dbH1RKb-VGMkfJbJXIn-V9OzFwLbrvLJmT-4c9MBsADZFabf_L8nn62w3GQ2NInT2a99Q_kNyQQWTb48LmeEYzdMF7cvfxIh5uA</recordid><startdate>201208</startdate><enddate>201208</enddate><creator>Al-Rahawan, Mohamad M.</creator><creator>Siebert, James D.</creator><creator>Mitchell, Craig S.</creator><creator>Smith, Stephen D.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201208</creationdate><title>Durable complete response to chemotherapy in an infant with a clival chordoma</title><author>Al-Rahawan, Mohamad M. ; Siebert, James D. ; Mitchell, Craig S. ; Smith, Stephen D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3307-717affeaf6f9c5ddab03832c517d6d85296ec553b5512fe4415ccda686354d603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Brain Mapping</topic><topic>chemotherapy</topic><topic>child</topic><topic>chordoma</topic><topic>Chordoma - diagnosis</topic><topic>Chordoma - drug therapy</topic><topic>clivus</topic><topic>Cyclophosphamide - administration & dosage</topic><topic>Doxorubicin - administration & dosage</topic><topic>Etoposide - administration & dosage</topic><topic>Humans</topic><topic>Ifosfamide - administration & dosage</topic><topic>Infant</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Remission Induction</topic><topic>Skull Base Neoplasms - diagnosis</topic><topic>Skull Base Neoplasms - drug therapy</topic><topic>Vincristine - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Rahawan, Mohamad M.</creatorcontrib><creatorcontrib>Siebert, James D.</creatorcontrib><creatorcontrib>Mitchell, Craig S.</creatorcontrib><creatorcontrib>Smith, Stephen D.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Pediatric blood & cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Rahawan, Mohamad M.</au><au>Siebert, James D.</au><au>Mitchell, Craig S.</au><au>Smith, Stephen D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Durable complete response to chemotherapy in an infant with a clival chordoma</atitle><jtitle>Pediatric blood & cancer</jtitle><addtitle>Pediatr. 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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use Brain Mapping chemotherapy child chordoma Chordoma - diagnosis Chordoma - drug therapy clivus Cyclophosphamide - administration & dosage Doxorubicin - administration & dosage Etoposide - administration & dosage Humans Ifosfamide - administration & dosage Infant Magnetic Resonance Imaging Male Remission Induction Skull Base Neoplasms - diagnosis Skull Base Neoplasms - drug therapy Vincristine - administration & dosage |
| title | Durable complete response to chemotherapy in an infant with a clival chordoma |
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