Overexpression of the oncostatin M receptor in cervical squamous cell carcinoma cells is associated with a pro-angiogenic phenotype and increased cell motility and invasiveness

Oncostatin M receptor (OSMR) shows frequent copy number gain and overexpression in advanced cervical squamous cell carcinoma (SCC). We used cell‐based in vitro assays, RNA interference, and integrative gene expression profiling to investigate the functional significance of this observation. CaSki an...

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Veröffentlicht in:	The Journal of pathology 2011-11, Vol.225 (3), p.448-462
Hauptverfasser:	Winder, David M, Chattopadhyay, Anasuya, Muralidhar, Balaji, Bauer, Julien, English, William R, Zhang, Xiao, Karagavriilidou, Konstantina, Roberts, Ian, Pett, Mark R, Murphy, Gillian, Coleman, Nicholas
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Antineoplastic Agents - pharmacology Biological and medical sciences Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Carcinoma, Squamous Cell - blood supply Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology cell migration Cell Movement - drug effects Cell Proliferation cervix Dermatology Female Female genital diseases gene expression Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic - drug effects Gynecology. Andrology. Obstetrics Humans invasion Investigative techniques, diagnostic techniques (general aspects) Medical sciences Neoplasm Invasiveness Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplastic Stem Cells - pathology Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Oligonucleotide Array Sequence Analysis - methods oncostatin M Oncostatin M - pharmacology oncostatin M receptor Oncostatin M Receptor beta Subunit - biosynthesis Oncostatin M Receptor beta Subunit - genetics Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques RNA, Neoplasm - genetics RNA, Small Interfering - genetics Signal Transduction - drug effects squamous cell carcinoma Tumor Cells, Cultured Tumors Tumors of the skin and soft tissue. Premalignant lesions Uterine Cervical Neoplasms - blood supply Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology Vascular Endothelial Growth Factor A - metabolism
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