HPV-associated skin disease
Human papillomaviruses (HPVs) are DNA tumour viruses that induce hyperproliferative lesions in cutaneous and mucosal epithelia. The relationship between HPV and non‐melanoma skin cancer (NMSC) is important clinically since NMSC is the most common form of malignancy among fair‐skinned populations. It...
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| Veröffentlicht in: | The Journal of pathology 2006-01, Vol.208 (2), p.165-175 |
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| container_title | The Journal of pathology |
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| creator | Akgül, Baki Cooke, James C Storey, Alan |
| description | Human papillomaviruses (HPVs) are DNA tumour viruses that induce hyperproliferative lesions in cutaneous and mucosal epithelia. The relationship between HPV and non‐melanoma skin cancer (NMSC) is important clinically since NMSC is the most common form of malignancy among fair‐skinned populations. It is well established that solar ultraviolet (UV) irradiation is the major risk factor for developing NMSC, but a pathogenic role for HPV in the development of NMSC has also been proposed. Recent molecular studies reveal a likely role for HPV infection in skin carcinogenesis as a co‐factor in association with UV. This review summarizes the literature describing these data, highlights some of the important findings derived from these studies, and speculates on future perspectives. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/path.1893 |
| format | Article |
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Published by John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4273-4a43b7c5da995bcbb6126dc61a239ffe0d142b0e3a5bfb5d9e28fda57865601a3</citedby><cites>FETCH-LOGICAL-c4273-4a43b7c5da995bcbb6126dc61a239ffe0d142b0e3a5bfb5d9e28fda57865601a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpath.1893$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpath.1893$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16362995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akgül, Baki</creatorcontrib><creatorcontrib>Cooke, James C</creatorcontrib><creatorcontrib>Storey, Alan</creatorcontrib><title>HPV-associated skin disease</title><title>The Journal of pathology</title><addtitle>J. Pathol</addtitle><description>Human papillomaviruses (HPVs) are DNA tumour viruses that induce hyperproliferative lesions in cutaneous and mucosal epithelia. The relationship between HPV and non‐melanoma skin cancer (NMSC) is important clinically since NMSC is the most common form of malignancy among fair‐skinned populations. It is well established that solar ultraviolet (UV) irradiation is the major risk factor for developing NMSC, but a pathogenic role for HPV in the development of NMSC has also been proposed. Recent molecular studies reveal a likely role for HPV infection in skin carcinogenesis as a co‐factor in association with UV. This review summarizes the literature describing these data, highlights some of the important findings derived from these studies, and speculates on future perspectives. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>apoptosis</subject><subject>Apoptosis - radiation effects</subject><subject>Cell Cycle - physiology</subject><subject>Cells, Cultured</subject><subject>DNA Repair - genetics</subject><subject>Epidermodysplasia Verruciformis - virology</subject><subject>HPV</subject><subject>Humans</subject><subject>Immune Tolerance - immunology</subject><subject>Keratinocytes - virology</subject><subject>non-melanoma skin cancer</subject><subject>Papillomaviridae - physiology</subject><subject>Papillomaviridae - radiation effects</subject><subject>Papillomavirus Infections - complications</subject><subject>Skin Diseases, Infectious - complications</subject><subject>Skin Diseases, Infectious - virology</subject><subject>Skin Neoplasms - genetics</subject><subject>Skin Neoplasms - virology</subject><subject>stem cell</subject><subject>transformation</subject><subject>Ultraviolet Rays - adverse effects</subject><issn>0022-3417</issn><issn>1096-9896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1j89LwzAUgIMobk4PngXZ1UO2_GjS5jiGW51DB049hpcmxbjNlaai--9tadGTp_fgfe-DD6FLSkaUEDYuoHob0UTxI9SnREmsEiWPUb--McwjGvfQWQjvhBClhDhFPSq5ZPXeR1fp6gVDCPvMQ-XsMGz8x9D64CC4c3SSwza4i24O0PPsdj1N8fJxfjedLHEWsZjjCCJu4kxYqI0mM0ZSJm0mKTCu8twRSyNmiOMgTG6EVY4luQURJ1JIQoEP0E3rzcp9CKXLdVH6HZQHTYluAnUTqJvAmr1u2eLT7Jz9I7uiGhi3wJffusP_Jr2arNNOidsPHyr3_fsB5UbLmMdCvz7M9SKl6SJ9mul7_gPXWmjP</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>Akgül, Baki</creator><creator>Cooke, James C</creator><creator>Storey, Alan</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200601</creationdate><title>HPV-associated skin disease</title><author>Akgül, Baki ; Cooke, James C ; Storey, Alan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4273-4a43b7c5da995bcbb6126dc61a239ffe0d142b0e3a5bfb5d9e28fda57865601a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>apoptosis</topic><topic>Apoptosis - radiation effects</topic><topic>Cell Cycle - physiology</topic><topic>Cells, Cultured</topic><topic>DNA Repair - genetics</topic><topic>Epidermodysplasia Verruciformis - virology</topic><topic>HPV</topic><topic>Humans</topic><topic>Immune Tolerance - immunology</topic><topic>Keratinocytes - virology</topic><topic>non-melanoma skin cancer</topic><topic>Papillomaviridae - physiology</topic><topic>Papillomaviridae - radiation effects</topic><topic>Papillomavirus Infections - complications</topic><topic>Skin Diseases, Infectious - complications</topic><topic>Skin Diseases, Infectious - virology</topic><topic>Skin Neoplasms - genetics</topic><topic>Skin Neoplasms - virology</topic><topic>stem cell</topic><topic>transformation</topic><topic>Ultraviolet Rays - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akgül, Baki</creatorcontrib><creatorcontrib>Cooke, James C</creatorcontrib><creatorcontrib>Storey, Alan</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The Journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akgül, Baki</au><au>Cooke, James C</au><au>Storey, Alan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HPV-associated skin disease</atitle><jtitle>The Journal of pathology</jtitle><addtitle>J. Pathol</addtitle><date>2006-01</date><risdate>2006</risdate><volume>208</volume><issue>2</issue><spage>165</spage><epage>175</epage><pages>165-175</pages><issn>0022-3417</issn><eissn>1096-9896</eissn><abstract>Human papillomaviruses (HPVs) are DNA tumour viruses that induce hyperproliferative lesions in cutaneous and mucosal epithelia. The relationship between HPV and non‐melanoma skin cancer (NMSC) is important clinically since NMSC is the most common form of malignancy among fair‐skinned populations. It is well established that solar ultraviolet (UV) irradiation is the major risk factor for developing NMSC, but a pathogenic role for HPV in the development of NMSC has also been proposed. Recent molecular studies reveal a likely role for HPV infection in skin carcinogenesis as a co‐factor in association with UV. This review summarizes the literature describing these data, highlights some of the important findings derived from these studies, and speculates on future perspectives. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>16362995</pmid><doi>10.1002/path.1893</doi><tpages>11</tpages></addata></record> |
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| ispartof | The Journal of pathology, 2006-01, Vol.208 (2), p.165-175 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animals Animals, Genetically Modified apoptosis Apoptosis - radiation effects Cell Cycle - physiology Cells, Cultured DNA Repair - genetics Epidermodysplasia Verruciformis - virology HPV Humans Immune Tolerance - immunology Keratinocytes - virology non-melanoma skin cancer Papillomaviridae - physiology Papillomaviridae - radiation effects Papillomavirus Infections - complications Skin Diseases, Infectious - complications Skin Diseases, Infectious - virology Skin Neoplasms - genetics Skin Neoplasms - virology stem cell transformation Ultraviolet Rays - adverse effects |
| title | HPV-associated skin disease |
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