Increased inflammatory reactivity in newly formed lining tissue
The air pouch has been shown to provide a convenient model for studying the behaviour of synovial lining tissue. Air pouches of different ages were used to study the reactivity of newly developing lining tissue towards irritants known to cause inflammation. Pouches of 1 day in age were relatively in...
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| Veröffentlicht in: | The Journal of pathology 1983-12, Vol.141 (4), p.483-495 |
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| container_end_page | 495 |
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| container_issue | 4 |
| container_start_page | 483 |
| container_title | The Journal of pathology |
| container_volume | 141 |
| creator | Sedgwick, A. D. Sin, Y. M. Edwards, J. C. W. Willoughby, D. A. |
| description | The air pouch has been shown to provide a convenient model for studying the behaviour of synovial lining tissue. Air pouches of different ages were used to study the reactivity of newly developing lining tissue towards irritants known to cause inflammation. Pouches of 1 day in age were relatively inert in their reactivity as judged by the number of cells and volume of the exudate accumulating in the pouch. In contrast, 3‐day‐old pouches responded to a much greater extent, and 6‐day‐old pouches were highly responsive with a further increase in cell numbers and fluid volume. The different responses of 1‐, 3‐ and 6‐day‐old pouches could be explained by (a) developing vascularity of the pouch, (b) formation of an organised lining of phagocytic cells, or (c) an increasingly organised mechanical barrier that retains the irritant and products of the inflammatory response. These studies of air pouch lining development permit a dissection of those components necessary for inflammatory reactivity of a lining tissue and may help explain the sensitivity of synovium to chronic inflammation. |
| doi_str_mv | 10.1002/path.1711410406 |
| format | Article |
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D. ; Sin, Y. M. ; Edwards, J. C. W. ; Willoughby, D. A.</creator><creatorcontrib>Sedgwick, A. D. ; Sin, Y. M. ; Edwards, J. C. W. ; Willoughby, D. A.</creatorcontrib><description>The air pouch has been shown to provide a convenient model for studying the behaviour of synovial lining tissue. Air pouches of different ages were used to study the reactivity of newly developing lining tissue towards irritants known to cause inflammation. Pouches of 1 day in age were relatively inert in their reactivity as judged by the number of cells and volume of the exudate accumulating in the pouch. In contrast, 3‐day‐old pouches responded to a much greater extent, and 6‐day‐old pouches were highly responsive with a further increase in cell numbers and fluid volume. The different responses of 1‐, 3‐ and 6‐day‐old pouches could be explained by (a) developing vascularity of the pouch, (b) formation of an organised lining of phagocytic cells, or (c) an increasingly organised mechanical barrier that retains the irritant and products of the inflammatory response. These studies of air pouch lining development permit a dissection of those components necessary for inflammatory reactivity of a lining tissue and may help explain the sensitivity of synovium to chronic inflammation.</description><identifier>ISSN: 0022-3417</identifier><identifier>EISSN: 1096-9896</identifier><identifier>DOI: 10.1002/path.1711410406</identifier><identifier>PMID: 6663391</identifier><identifier>CODEN: JPTLAS</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Air ; Animals ; Biological and medical sciences ; Calcium Pyrophosphate ; Carrageenan ; Disease Models, Animal ; General aspects ; Male ; Medical sciences ; Rats ; Rats, Inbred Strains ; Synovial Membrane - pathology ; Synovitis - chemically induced ; Synovitis - pathology ; Uric Acid</subject><ispartof>The Journal of pathology, 1983-12, Vol.141 (4), p.483-495</ispartof><rights>Copyright © 1983 The Pathological Society of Great Britain and Ireland</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4776-7d4f68df33237cd356c6d7dfe66a936bc03935667ec999b8bf7a3941ad66cca73</citedby><cites>FETCH-LOGICAL-c4776-7d4f68df33237cd356c6d7dfe66a936bc03935667ec999b8bf7a3941ad66cca73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpath.1711410406$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpath.1711410406$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9513463$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6663391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sedgwick, A. D.</creatorcontrib><creatorcontrib>Sin, Y. M.</creatorcontrib><creatorcontrib>Edwards, J. C. W.</creatorcontrib><creatorcontrib>Willoughby, D. A.</creatorcontrib><title>Increased inflammatory reactivity in newly formed lining tissue</title><title>The Journal of pathology</title><addtitle>J. Pathol</addtitle><description>The air pouch has been shown to provide a convenient model for studying the behaviour of synovial lining tissue. Air pouches of different ages were used to study the reactivity of newly developing lining tissue towards irritants known to cause inflammation. Pouches of 1 day in age were relatively inert in their reactivity as judged by the number of cells and volume of the exudate accumulating in the pouch. In contrast, 3‐day‐old pouches responded to a much greater extent, and 6‐day‐old pouches were highly responsive with a further increase in cell numbers and fluid volume. The different responses of 1‐, 3‐ and 6‐day‐old pouches could be explained by (a) developing vascularity of the pouch, (b) formation of an organised lining of phagocytic cells, or (c) an increasingly organised mechanical barrier that retains the irritant and products of the inflammatory response. These studies of air pouch lining development permit a dissection of those components necessary for inflammatory reactivity of a lining tissue and may help explain the sensitivity of synovium to chronic inflammation.</description><subject>Air</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium Pyrophosphate</subject><subject>Carrageenan</subject><subject>Disease Models, Animal</subject><subject>General aspects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Synovial Membrane - pathology</subject><subject>Synovitis - chemically induced</subject><subject>Synovitis - pathology</subject><subject>Uric Acid</subject><issn>0022-3417</issn><issn>1096-9896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9PwjAUxxujQUTPnkx28Dpo6fa6xoMxqEBCFBKMx6brWq2OQdoh7r-3BILx5Okl3_f5vh9fhC4J7hKM-72VrN-7hBGSEJxgOEJtgjnEPONwjNqB6Mc0IewUnXn_gTHmPE1bqAUAlHLSRrfjSjktvS4iW5lSLhayXromCpqq7Zetm6BHld6UTWSWbhG40la2eotq6_1an6MTI0uvL_a1g14eH-aDUTx5Ho4Hd5NYJYxBzIrEQFYYSvuUqYKmoKBghdEAklPIFaY8iMC04pznWW6YpDwhsgBQSjLaQb3dXOWW3jttxMrZhXSNIFhskxDbJMRvEsFxtXOs1nk4-8DvXw_9631feiVL42SlrD9gPCU0CWQH3eywjS11899WMb2bj_4cEe_c1tf6--CW7lMAoywVr09DkQ3vyWQ6nIkZ_QHcH4ev</recordid><startdate>198312</startdate><enddate>198312</enddate><creator>Sedgwick, A. D.</creator><creator>Sin, Y. M.</creator><creator>Edwards, J. C. W.</creator><creator>Willoughby, D. A.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198312</creationdate><title>Increased inflammatory reactivity in newly formed lining tissue</title><author>Sedgwick, A. D. ; Sin, Y. M. ; Edwards, J. C. W. ; Willoughby, D. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4776-7d4f68df33237cd356c6d7dfe66a936bc03935667ec999b8bf7a3941ad66cca73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Air</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcium Pyrophosphate</topic><topic>Carrageenan</topic><topic>Disease Models, Animal</topic><topic>General aspects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Synovial Membrane - pathology</topic><topic>Synovitis - chemically induced</topic><topic>Synovitis - pathology</topic><topic>Uric Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sedgwick, A. D.</creatorcontrib><creatorcontrib>Sin, Y. M.</creatorcontrib><creatorcontrib>Edwards, J. C. W.</creatorcontrib><creatorcontrib>Willoughby, D. A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The Journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sedgwick, A. D.</au><au>Sin, Y. M.</au><au>Edwards, J. C. W.</au><au>Willoughby, D. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased inflammatory reactivity in newly formed lining tissue</atitle><jtitle>The Journal of pathology</jtitle><addtitle>J. Pathol</addtitle><date>1983-12</date><risdate>1983</risdate><volume>141</volume><issue>4</issue><spage>483</spage><epage>495</epage><pages>483-495</pages><issn>0022-3417</issn><eissn>1096-9896</eissn><coden>JPTLAS</coden><abstract>The air pouch has been shown to provide a convenient model for studying the behaviour of synovial lining tissue. Air pouches of different ages were used to study the reactivity of newly developing lining tissue towards irritants known to cause inflammation. Pouches of 1 day in age were relatively inert in their reactivity as judged by the number of cells and volume of the exudate accumulating in the pouch. In contrast, 3‐day‐old pouches responded to a much greater extent, and 6‐day‐old pouches were highly responsive with a further increase in cell numbers and fluid volume. The different responses of 1‐, 3‐ and 6‐day‐old pouches could be explained by (a) developing vascularity of the pouch, (b) formation of an organised lining of phagocytic cells, or (c) an increasingly organised mechanical barrier that retains the irritant and products of the inflammatory response. These studies of air pouch lining development permit a dissection of those components necessary for inflammatory reactivity of a lining tissue and may help explain the sensitivity of synovium to chronic inflammation.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>6663391</pmid><doi>10.1002/path.1711410406</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | The Journal of pathology, 1983-12, Vol.141 (4), p.483-495 |
| issn | 0022-3417 1096-9896 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Air Animals Biological and medical sciences Calcium Pyrophosphate Carrageenan Disease Models, Animal General aspects Male Medical sciences Rats Rats, Inbred Strains Synovial Membrane - pathology Synovitis - chemically induced Synovitis - pathology Uric Acid |
| title | Increased inflammatory reactivity in newly formed lining tissue |
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