Differential toxicity of methylglyoxal-bis[guanylhydrazone]

The toxicity to cultured cells of the cancer chemotherapeutic agent methylglyoxal‐bis[guanylhydrazone] (MGBG) varies considerably between different cell lines and is always more toxic in the absence of exogenous polyamine. We have looked at the relative MGBG toxicity of two different murine melanoma...

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Veröffentlicht in:	The Journal of pathology 1983-02, Vol.139 (2), p.141-149
Hauptverfasser:	Dewey, D. L., Gaugas, J. M., Stratford, M. R. L., Minchinton, A. I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Count Cell Line DNA - biosynthesis Dose-Response Relationship, Drug Fibroblasts - drug effects Guanidines - pharmacology Melanoma Mice Mitoguazone - pharmacology Mitosis - drug effects Neoplasms, Experimental Protein Biosynthesis Spermine - pharmacology
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