Structural and functional characteristics of the microcirculation in neoplasms
The microcirculation in a transplantable rat fibrosarcoma was investigated. The vasculature of the neoplasm consisted of irregular channels lined by plump endothelium which displayed mainly pentalaminar although a few heptalaminar junctions were also found. Few pericytes surround the endothelial lay...
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| Veröffentlicht in: | The Journal of pathology 1975-06, Vol.116 (2), p.65-72 |
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| container_title | The Journal of pathology |
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| creator | Papadimitriou, J. M. Woods, A. E. |
| description | The microcirculation in a transplantable rat fibrosarcoma was investigated. The vasculature of the neoplasm consisted of irregular channels lined by plump endothelium which displayed mainly pentalaminar although a few heptalaminar junctions were also found. Few pericytes surround the endothelial layer while the basement-membrane varied in thickness and was often duplicated and triplicated. Challenge with histamine resulted in increased permeability in comparison with normal connective tissues similarly treated. The increased permeability was accompanied by the formation of interendothelial gaps in these irregular vascular channels. Carrageenan induced a leucocytic exudate in the neoplasm which, apart from an increase in the mononuclear concentration 2 wk after injection, varied little from normal connective tissues. It is concluded that the majority of vascular channels in this neoplasm bear some structural and functional relationship to small venules. |
| doi_str_mv | 10.1002/path.1711160202 |
| format | Article |
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It is concluded that the majority of vascular channels in this neoplasm bear some structural and functional relationship to small venules.</description><identifier>ISSN: 0022-3417</identifier><identifier>EISSN: 1096-9896</identifier><identifier>DOI: 10.1002/path.1711160202</identifier><identifier>PMID: 168332</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Angiography ; Animals ; Basement Membrane ; Blood Vessels - pathology ; Capillary Permeability - drug effects ; Carrageenan - pharmacology ; Endothelium - ultrastructure ; Fibrosarcoma - chemically induced ; Fibrosarcoma - pathology ; Histamine - pharmacology ; Inclusion Bodies ; Intercellular Junctions ; Methylcholanthrene ; Microcirculation ; Microscopy, Electron ; Phlebography ; Rats ; Sarcoma, Experimental - pathology ; Time Factors</subject><ispartof>The Journal of pathology, 1975-06, Vol.116 (2), p.65-72</ispartof><rights>Copyright © 1975 The Pathological Society of Great Britain and Ireland</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4762-aba58f9b28160741af0f879bb6367c95be7bbfbad9257dde998e0a8033fdc23c3</citedby><cites>FETCH-LOGICAL-c4762-aba58f9b28160741af0f879bb6367c95be7bbfbad9257dde998e0a8033fdc23c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpath.1711160202$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpath.1711160202$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/168332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Papadimitriou, J. M.</creatorcontrib><creatorcontrib>Woods, A. E.</creatorcontrib><title>Structural and functional characteristics of the microcirculation in neoplasms</title><title>The Journal of pathology</title><addtitle>J. Pathol</addtitle><description>The microcirculation in a transplantable rat fibrosarcoma was investigated. The vasculature of the neoplasm consisted of irregular channels lined by plump endothelium which displayed mainly pentalaminar although a few heptalaminar junctions were also found. Few pericytes surround the endothelial layer while the basement-membrane varied in thickness and was often duplicated and triplicated. Challenge with histamine resulted in increased permeability in comparison with normal connective tissues similarly treated. The increased permeability was accompanied by the formation of interendothelial gaps in these irregular vascular channels. Carrageenan induced a leucocytic exudate in the neoplasm which, apart from an increase in the mononuclear concentration 2 wk after injection, varied little from normal connective tissues. It is concluded that the majority of vascular channels in this neoplasm bear some structural and functional relationship to small venules.</description><subject>Angiography</subject><subject>Animals</subject><subject>Basement Membrane</subject><subject>Blood Vessels - pathology</subject><subject>Capillary Permeability - drug effects</subject><subject>Carrageenan - pharmacology</subject><subject>Endothelium - ultrastructure</subject><subject>Fibrosarcoma - chemically induced</subject><subject>Fibrosarcoma - pathology</subject><subject>Histamine - pharmacology</subject><subject>Inclusion Bodies</subject><subject>Intercellular Junctions</subject><subject>Methylcholanthrene</subject><subject>Microcirculation</subject><subject>Microscopy, Electron</subject><subject>Phlebography</subject><subject>Rats</subject><subject>Sarcoma, Experimental - pathology</subject><subject>Time Factors</subject><issn>0022-3417</issn><issn>1096-9896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoN4q9W1GxfzAtPm0kkmuCpFW0utghXBTUgyCY3OpSQzaN_eqSMWV64Oh__CzwfAJYIDBCEebmS9HiCGEKIQQ3wAeghyGvOU00PQax04JiPETsFZCG8QQs6T5AQcI5oSgntg-VT7RteNl3kkyyyyTalrV5Xtq9fSS10b70LtdIgqG9VrExVO-0o7r5tc7pyRK6PSVJtchiKcgyMr82Aufm4fPN_erCazePEwvZuMF7EeMYpjqWSSWq5w2q5mIyQttCnjSlFCmeaJMkwpq2TGccKyzHCeGihTSIjNNCaa9MGw6223hOCNFRvvCum3AkGx4yJ2XMSeS5u46hKbRhUm2_u_QbTydSd_uNxs_2sTj-PV7E953KVbVObzNy39u6CMsES8LKciofR1cj_HYk6-AIZygOY</recordid><startdate>197506</startdate><enddate>197506</enddate><creator>Papadimitriou, J. M.</creator><creator>Woods, A. E.</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>197506</creationdate><title>Structural and functional characteristics of the microcirculation in neoplasms</title><author>Papadimitriou, J. M. ; Woods, A. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4762-aba58f9b28160741af0f879bb6367c95be7bbfbad9257dde998e0a8033fdc23c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Angiography</topic><topic>Animals</topic><topic>Basement Membrane</topic><topic>Blood Vessels - pathology</topic><topic>Capillary Permeability - drug effects</topic><topic>Carrageenan - pharmacology</topic><topic>Endothelium - ultrastructure</topic><topic>Fibrosarcoma - chemically induced</topic><topic>Fibrosarcoma - pathology</topic><topic>Histamine - pharmacology</topic><topic>Inclusion Bodies</topic><topic>Intercellular Junctions</topic><topic>Methylcholanthrene</topic><topic>Microcirculation</topic><topic>Microscopy, Electron</topic><topic>Phlebography</topic><topic>Rats</topic><topic>Sarcoma, Experimental - pathology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Papadimitriou, J. M.</creatorcontrib><creatorcontrib>Woods, A. E.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The Journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Papadimitriou, J. M.</au><au>Woods, A. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural and functional characteristics of the microcirculation in neoplasms</atitle><jtitle>The Journal of pathology</jtitle><addtitle>J. Pathol</addtitle><date>1975-06</date><risdate>1975</risdate><volume>116</volume><issue>2</issue><spage>65</spage><epage>72</epage><pages>65-72</pages><issn>0022-3417</issn><eissn>1096-9896</eissn><abstract>The microcirculation in a transplantable rat fibrosarcoma was investigated. The vasculature of the neoplasm consisted of irregular channels lined by plump endothelium which displayed mainly pentalaminar although a few heptalaminar junctions were also found. Few pericytes surround the endothelial layer while the basement-membrane varied in thickness and was often duplicated and triplicated. Challenge with histamine resulted in increased permeability in comparison with normal connective tissues similarly treated. The increased permeability was accompanied by the formation of interendothelial gaps in these irregular vascular channels. Carrageenan induced a leucocytic exudate in the neoplasm which, apart from an increase in the mononuclear concentration 2 wk after injection, varied little from normal connective tissues. It is concluded that the majority of vascular channels in this neoplasm bear some structural and functional relationship to small venules.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>168332</pmid><doi>10.1002/path.1711160202</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3417 |
| ispartof | The Journal of pathology, 1975-06, Vol.116 (2), p.65-72 |
| issn | 0022-3417 1096-9896 |
| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Angiography Animals Basement Membrane Blood Vessels - pathology Capillary Permeability - drug effects Carrageenan - pharmacology Endothelium - ultrastructure Fibrosarcoma - chemically induced Fibrosarcoma - pathology Histamine - pharmacology Inclusion Bodies Intercellular Junctions Methylcholanthrene Microcirculation Microscopy, Electron Phlebography Rats Sarcoma, Experimental - pathology Time Factors |
| title | Structural and functional characteristics of the microcirculation in neoplasms |
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