Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas

Intestinal metaplasia (IM) is part of a stepwise sequence of alterations of the gastric mucosa, leading ultimately to gastric cancer, and is strongly associated with chronic Helicobacter pylori infection. The molecular mechanisms underlying the onset of IM remain elusive. The aim of this study was t...

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Veröffentlicht in:	The Journal of pathology 2003-01, Vol.199 (1), p.36-40
Hauptverfasser:	Almeida, Raquel, Silva, Elisabete, Santos-Silva, Filipe, Silberg, Debra G, Wang, Jiangfu, De Bolós, Carmen, David, Leonor
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers, Tumor - metabolism CDX1 CDX2 CDX2 Transcription Factor gastric carcinoma Gastric Mucosa - metabolism Gastric Mucosa - pathology Gastroenterology. Liver. Pancreas. Abdomen homeobox genes Homeodomain Proteins - metabolism Humans Immunohistochemistry - methods intestinal metaplasia Medical sciences Metaplasia - metabolism Metaplasia - pathology MUC2 Mucin 5AC Mucin-2 mucins Mucins - metabolism Neoplasm Proteins - metabolism Stomach - pathology Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Trans-Activators - metabolism Tumors
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