Gosha-jinki-gan reduces transmitter proteins and sensory receptors associated with C fiber activation induced by acetic acid in rat urinary bladder

Aim We determined if Gosha‐jinki‐gan, a traditional Chinese herbal mixture, reduced the presence of the tachykinins neurokinin A, neurokinin B, and substance P, as well as the transient receptor potential vanilloid 1 (TRPV1) and P2X3 purine receptors that are functionally associated with C fibers in...

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Veröffentlicht in:	Neurourology and urodynamics 2008-01, Vol.27 (8), p.832-837
Hauptverfasser:	Imamura, Tetsuya, Ishizuka, Osamu, Aizawa, Naoki, Zhong, Chen, Ogawa, Teruyuki, Nakayama, Tsuyoshi, Tanabe, Tomoaki, Nishizawa, Osamu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic Acid Animals C fibers Disease Models, Animal Drugs, Chinese Herbal - pharmacology Female Gosha-jinki-gan Immunohistochemistry Nerve Fibers, Unmyelinated - drug effects Nerve Fibers, Unmyelinated - metabolism Neurokinin A - metabolism Neurokinin B - metabolism P2X3 purine receptor rat Rats Rats, Sprague-Dawley Receptors, Purinergic P2 - genetics Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2X3 Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Substance P - metabolism tachykinins Tachykinins - genetics Tachykinins - metabolism TRPV Cation Channels - genetics TRPV Cation Channels - metabolism TRPV1 receptor urinary bladder Urinary Bladder - innervation Urinary Bladder, Overactive - chemically induced Urinary Bladder, Overactive - drug therapy Urinary Bladder, Overactive - metabolism Urinary Bladder, Overactive - physiopathology Urothelium - innervation
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