Effect of botulinum neurotoxin treatment in the lateral spread monitoring of microvascular decompression for hemifacial spasm
Introduction: Botulinum neurotoxin (BtNtx) treatment for hemifacial spasm (HFS) prior to microvascular decompression (MVD) is hypothesized to be a factor in the variability of intraoperative neurophysiological monitoring (IONM) during this procedure. Methods: We analyzed 282 MVDs performed at the Un...
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| Veröffentlicht in: | Muscle & nerve 2011-10, Vol.44 (4), p.518-524 |
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| creator | Habeych, Miguel E. Shah, Aalap C. Nikonow, Tara N. Balzer, Jeffrey R. Crammond, Donald J. Thirumala, Parthasarathy D. Kassam, Amin Horowitz, Michael |
| description | Introduction: Botulinum neurotoxin (BtNtx) treatment for hemifacial spasm (HFS) prior to microvascular decompression (MVD) is hypothesized to be a factor in the variability of intraoperative neurophysiological monitoring (IONM) during this procedure. Methods: We analyzed 282 MVDs performed at the University of Pittsburgh Medical Center between January 1, 2000 and December 31, 2007. We retrospectively compared the lateral spread response (LSR) in the mentalis muscle when stimulus‐triggered electromyography (EMG) was elicited from the facial nerve. Previous BtNtx treatment was the grouping factor. Results: Baseline LSR amplitudes during MVD (prior BtNtx: mean = 341.47 μV; no BtNtx: mean = 241.81 μV) were significantly different between groups (df = 1,281; t = −2.463; P = 0.014). Comparisons of latency and current threshold at baseline, as well as HFS disappearance or LSR persistence after the procedure, did not achieve statistical significance. Conclusions: HFS patients treated with BtNtx prior to MVD demonstrated higher LSR baseline amplitudes during IONM. This could be related to muscle poly‐reinnervation after recovery from repeated BtNtx use. Muscle Nerve, 2011 |
| doi_str_mv | 10.1002/mus.22104 |
| format | Article |
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Methods: We analyzed 282 MVDs performed at the University of Pittsburgh Medical Center between January 1, 2000 and December 31, 2007. We retrospectively compared the lateral spread response (LSR) in the mentalis muscle when stimulus‐triggered electromyography (EMG) was elicited from the facial nerve. Previous BtNtx treatment was the grouping factor. Results: Baseline LSR amplitudes during MVD (prior BtNtx: mean = 341.47 μV; no BtNtx: mean = 241.81 μV) were significantly different between groups (df = 1,281; t = −2.463; P = 0.014). Comparisons of latency and current threshold at baseline, as well as HFS disappearance or LSR persistence after the procedure, did not achieve statistical significance. Conclusions: HFS patients treated with BtNtx prior to MVD demonstrated higher LSR baseline amplitudes during IONM. This could be related to muscle poly‐reinnervation after recovery from repeated BtNtx use. Muscle Nerve, 2011</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.22104</identifier><identifier>PMID: 21826681</identifier><identifier>CODEN: MUNEDE</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Action Potentials - drug effects ; Action Potentials - physiology ; Adult ; Anti-Dyskinesia Agents - therapeutic use ; Biological and medical sciences ; botulinum neurotoxin ; Botulinum Toxins - therapeutic use ; Decompression, Surgical - methods ; Electric Stimulation - methods ; Electromyography ; Female ; hemifacial spasm ; Hemifacial Spasm - drug therapy ; Hemifacial Spasm - surgery ; Humans ; intraoperative neurophysiological monitoring ; lateral spread response ; Male ; Medical sciences ; microvascular decompression ; Middle Aged ; Monitoring, Intraoperative - methods ; Muscle ; Muscle, Skeletal - physiopathology ; Pharmacology. Drug treatments ; Reaction Time ; Retrospective Studies ; Treatment Outcome</subject><ispartof>Muscle & nerve, 2011-10, Vol.44 (4), p.518-524</ispartof><rights>Copyright © 2011 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3924-c6f75ee7a2fec56af4385289e53443f6d2667507d6c55e188a81e90cb72107443</citedby><cites>FETCH-LOGICAL-c3924-c6f75ee7a2fec56af4385289e53443f6d2667507d6c55e188a81e90cb72107443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.22104$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.22104$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24570835$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21826681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Habeych, Miguel E.</creatorcontrib><creatorcontrib>Shah, Aalap C.</creatorcontrib><creatorcontrib>Nikonow, Tara N.</creatorcontrib><creatorcontrib>Balzer, Jeffrey R.</creatorcontrib><creatorcontrib>Crammond, Donald J.</creatorcontrib><creatorcontrib>Thirumala, Parthasarathy D.</creatorcontrib><creatorcontrib>Kassam, Amin</creatorcontrib><creatorcontrib>Horowitz, Michael</creatorcontrib><title>Effect of botulinum neurotoxin treatment in the lateral spread monitoring of microvascular decompression for hemifacial spasm</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Introduction: Botulinum neurotoxin (BtNtx) treatment for hemifacial spasm (HFS) prior to microvascular decompression (MVD) is hypothesized to be a factor in the variability of intraoperative neurophysiological monitoring (IONM) during this procedure. Methods: We analyzed 282 MVDs performed at the University of Pittsburgh Medical Center between January 1, 2000 and December 31, 2007. We retrospectively compared the lateral spread response (LSR) in the mentalis muscle when stimulus‐triggered electromyography (EMG) was elicited from the facial nerve. Previous BtNtx treatment was the grouping factor. Results: Baseline LSR amplitudes during MVD (prior BtNtx: mean = 341.47 μV; no BtNtx: mean = 241.81 μV) were significantly different between groups (df = 1,281; t = −2.463; P = 0.014). Comparisons of latency and current threshold at baseline, as well as HFS disappearance or LSR persistence after the procedure, did not achieve statistical significance. Conclusions: HFS patients treated with BtNtx prior to MVD demonstrated higher LSR baseline amplitudes during IONM. This could be related to muscle poly‐reinnervation after recovery from repeated BtNtx use. Muscle Nerve, 2011</description><subject>Action Potentials - drug effects</subject><subject>Action Potentials - physiology</subject><subject>Adult</subject><subject>Anti-Dyskinesia Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>botulinum neurotoxin</subject><subject>Botulinum Toxins - therapeutic use</subject><subject>Decompression, Surgical - methods</subject><subject>Electric Stimulation - methods</subject><subject>Electromyography</subject><subject>Female</subject><subject>hemifacial spasm</subject><subject>Hemifacial Spasm - drug therapy</subject><subject>Hemifacial Spasm - surgery</subject><subject>Humans</subject><subject>intraoperative neurophysiological monitoring</subject><subject>lateral spread response</subject><subject>Male</subject><subject>Medical sciences</subject><subject>microvascular decompression</subject><subject>Middle Aged</subject><subject>Monitoring, Intraoperative - methods</subject><subject>Muscle</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Reaction Time</subject><subject>Retrospective Studies</subject><subject>Treatment Outcome</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtvFDEURi0EIkug4A8gNxQUk9jj55RolQSkAEUI0FlezzUxjMcr2wNJwX_Hm01CRWVd-Xz3cRB6SckRJaQ_jks56ntK-CO0omRQHReDfoxWhHLdSTZ8O0DPSvlBCKFaqqfooKe6l1LTFfpz4j24ipPHm1SXKcxLxDMsOdV0HWZcM9gaYa54V1wBnmyFbCdctu1nxDHNoaYc5u-7FjG4nH7Z4pbJZjyCS7FhpYQ0Y58yvoIYvHXhNm9LfI6eeDsVeHH3HqLL05PP63fd-aez9-u3551jQ887J70SAMr2bVchredMi14PIBjnzMuxHaMEUaN0QgDV2moKA3Eb1aSohhyiN_u-bb1SMnizzSHafGMoMTuFpik0twob-2rPbpdNhPGBvHfWgNd3QDvUTj7b2YXyj-NCEc1E44733O8wwc3_J5oPlxf3o7t9IpQK1w8Jm38aqZgS5uvHM6NOmfoi-dpcsL_gHpm6</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Habeych, Miguel E.</creator><creator>Shah, Aalap C.</creator><creator>Nikonow, Tara N.</creator><creator>Balzer, Jeffrey R.</creator><creator>Crammond, Donald J.</creator><creator>Thirumala, Parthasarathy D.</creator><creator>Kassam, Amin</creator><creator>Horowitz, Michael</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201110</creationdate><title>Effect of botulinum neurotoxin treatment in the lateral spread monitoring of microvascular decompression for hemifacial spasm</title><author>Habeych, Miguel E. ; Shah, Aalap C. ; Nikonow, Tara N. ; Balzer, Jeffrey R. ; Crammond, Donald J. ; Thirumala, Parthasarathy D. ; Kassam, Amin ; Horowitz, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3924-c6f75ee7a2fec56af4385289e53443f6d2667507d6c55e188a81e90cb72107443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Action Potentials - drug effects</topic><topic>Action Potentials - physiology</topic><topic>Adult</topic><topic>Anti-Dyskinesia Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>botulinum neurotoxin</topic><topic>Botulinum Toxins - therapeutic use</topic><topic>Decompression, Surgical - methods</topic><topic>Electric Stimulation - methods</topic><topic>Electromyography</topic><topic>Female</topic><topic>hemifacial spasm</topic><topic>Hemifacial Spasm - drug therapy</topic><topic>Hemifacial Spasm - surgery</topic><topic>Humans</topic><topic>intraoperative neurophysiological monitoring</topic><topic>lateral spread response</topic><topic>Male</topic><topic>Medical sciences</topic><topic>microvascular decompression</topic><topic>Middle Aged</topic><topic>Monitoring, Intraoperative - methods</topic><topic>Muscle</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Reaction Time</topic><topic>Retrospective Studies</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Habeych, Miguel E.</creatorcontrib><creatorcontrib>Shah, Aalap C.</creatorcontrib><creatorcontrib>Nikonow, Tara N.</creatorcontrib><creatorcontrib>Balzer, Jeffrey R.</creatorcontrib><creatorcontrib>Crammond, Donald J.</creatorcontrib><creatorcontrib>Thirumala, Parthasarathy D.</creatorcontrib><creatorcontrib>Kassam, Amin</creatorcontrib><creatorcontrib>Horowitz, Michael</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Habeych, Miguel E.</au><au>Shah, Aalap C.</au><au>Nikonow, Tara N.</au><au>Balzer, Jeffrey R.</au><au>Crammond, Donald J.</au><au>Thirumala, Parthasarathy D.</au><au>Kassam, Amin</au><au>Horowitz, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of botulinum neurotoxin treatment in the lateral spread monitoring of microvascular decompression for hemifacial spasm</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2011-10</date><risdate>2011</risdate><volume>44</volume><issue>4</issue><spage>518</spage><epage>524</epage><pages>518-524</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><coden>MUNEDE</coden><abstract>Introduction: Botulinum neurotoxin (BtNtx) treatment for hemifacial spasm (HFS) prior to microvascular decompression (MVD) is hypothesized to be a factor in the variability of intraoperative neurophysiological monitoring (IONM) during this procedure. Methods: We analyzed 282 MVDs performed at the University of Pittsburgh Medical Center between January 1, 2000 and December 31, 2007. We retrospectively compared the lateral spread response (LSR) in the mentalis muscle when stimulus‐triggered electromyography (EMG) was elicited from the facial nerve. Previous BtNtx treatment was the grouping factor. Results: Baseline LSR amplitudes during MVD (prior BtNtx: mean = 341.47 μV; no BtNtx: mean = 241.81 μV) were significantly different between groups (df = 1,281; t = −2.463; P = 0.014). Comparisons of latency and current threshold at baseline, as well as HFS disappearance or LSR persistence after the procedure, did not achieve statistical significance. Conclusions: HFS patients treated with BtNtx prior to MVD demonstrated higher LSR baseline amplitudes during IONM. This could be related to muscle poly‐reinnervation after recovery from repeated BtNtx use. Muscle Nerve, 2011</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21826681</pmid><doi>10.1002/mus.22104</doi><tpages>7</tpages></addata></record> |
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| subjects | Action Potentials - drug effects Action Potentials - physiology Adult Anti-Dyskinesia Agents - therapeutic use Biological and medical sciences botulinum neurotoxin Botulinum Toxins - therapeutic use Decompression, Surgical - methods Electric Stimulation - methods Electromyography Female hemifacial spasm Hemifacial Spasm - drug therapy Hemifacial Spasm - surgery Humans intraoperative neurophysiological monitoring lateral spread response Male Medical sciences microvascular decompression Middle Aged Monitoring, Intraoperative - methods Muscle Muscle, Skeletal - physiopathology Pharmacology. Drug treatments Reaction Time Retrospective Studies Treatment Outcome |
| title | Effect of botulinum neurotoxin treatment in the lateral spread monitoring of microvascular decompression for hemifacial spasm |
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