The susceptibility of muscle cells to oxidative stress is independent of nitric oxide synthase expression

The free radical, nitric oxide (NO·), has been implicated in the pathogenesis of muscular dystrophies because the enzyme, nitric oxide synthase (NOS), which produces NO·, binds to the dystrophin–glycoprotein complex (DGC). In various studies of tissue samples from human and animal muscular dystrophi...

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Veröffentlicht in:	Muscle & nerve 2001-04, Vol.24 (4), p.502-511
Hauptverfasser:	Zhuang, Weiyun, Eby, Josh C., Cheong, Monica, Mohapatra, Pramit K., Bredt, David S., Disatnik, Marie-Hélène, Rando, Thomas A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Differentiation Cells, Cultured Disease Models, Animal Diseases of striated muscles. Neuromuscular diseases Dose-Response Relationship, Drug dystrophin Enzyme Inhibitors - pharmacology free radical Gene Expression - drug effects mdx Medical sciences Mice Mice, Inbred C57BL Mice, Inbred mdx Mice, Knockout Muscle, Skeletal - cytology Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism muscular dystrophy Muscular Dystrophy, Animal - genetics Muscular Dystrophy, Animal - metabolism Myofibrils - drug effects Myofibrils - metabolism Neurology nitric oxide nitric oxide synthase Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase - deficiency Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type I Oxidants - pharmacology oxidative stress Oxidative Stress - physiology Reactive Oxygen Species - metabolism Transfection
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