Assessing the effects of subject motion on T 2 relaxation under spin tagging (TRUST) cerebral oxygenation measurements using volume navigators
Subject motion may cause errors in estimates of blood T when using the T -relaxation under spin tagging (TRUST) technique on noncompliant subjects like neonates. By incorporating 3D volume navigators (vNavs) into the TRUST pulse sequence, independent measurements of motion during scanning permit eva...
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| Veröffentlicht in: | Magnetic resonance in medicine 2017-12, Vol.78 (6), p.2283-2289 |
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| creator | Stout, Jeffrey N Tisdall, M Dylan McDaniel, Patrick Gagoski, Borjan Bolar, Divya S Grant, Patricia Ellen Adalsteinsson, Elfar |
| description | Subject motion may cause errors in estimates of blood T
when using the T
-relaxation under spin tagging (TRUST) technique on noncompliant subjects like neonates. By incorporating 3D volume navigators (vNavs) into the TRUST pulse sequence, independent measurements of motion during scanning permit evaluation of these errors.
The effects of integrated vNavs on TRUST-based T
estimates were evaluated using simulations and in vivo subject data. Two subjects were scanned with the TRUST+vNav sequence during prescribed movements. Mean motion scores were derived from vNavs and TRUST images, along with a metric of exponential fit quality. Regression analysis was performed between T
estimates and mean motion scores. Also, motion scores were determined from independent neonatal scans.
vNavs negligibly affected venous blood T
estimates and better detected subject motion than fit quality metrics. Regression analysis showed that T
is biased upward by 4.1 ms per 1 mm of mean motion score. During neonatal scans, mean motion scores of 0.6 to 2.0 mm were detected.
Motion during TRUST causes an overestimate of T
, which suggests a cautious approach when comparing TRUST-based cerebral oxygenation measurements of noncompliant subjects. Magn Reson Med 78:2283-2289, 2017. © 2017 International Society for Magnetic Resonance in Medicine. |
| doi_str_mv | 10.1002/mrm.26616 |
| format | Article |
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when using the T
-relaxation under spin tagging (TRUST) technique on noncompliant subjects like neonates. By incorporating 3D volume navigators (vNavs) into the TRUST pulse sequence, independent measurements of motion during scanning permit evaluation of these errors.
The effects of integrated vNavs on TRUST-based T
estimates were evaluated using simulations and in vivo subject data. Two subjects were scanned with the TRUST+vNav sequence during prescribed movements. Mean motion scores were derived from vNavs and TRUST images, along with a metric of exponential fit quality. Regression analysis was performed between T
estimates and mean motion scores. Also, motion scores were determined from independent neonatal scans.
vNavs negligibly affected venous blood T
estimates and better detected subject motion than fit quality metrics. Regression analysis showed that T
is biased upward by 4.1 ms per 1 mm of mean motion score. During neonatal scans, mean motion scores of 0.6 to 2.0 mm were detected.
Motion during TRUST causes an overestimate of T
, which suggests a cautious approach when comparing TRUST-based cerebral oxygenation measurements of noncompliant subjects. Magn Reson Med 78:2283-2289, 2017. © 2017 International Society for Magnetic Resonance in Medicine.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.26616</identifier><identifier>PMID: 28247427</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Algorithms ; Brain - diagnostic imaging ; Computer Simulation ; Female ; Humans ; Image Enhancement ; Image Interpretation, Computer-Assisted ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Male ; Models, Statistical ; Motion ; Oximetry ; Oxygen - chemistry ; Regression Analysis ; Reproducibility of Results ; Young Adult</subject><ispartof>Magnetic resonance in medicine, 2017-12, Vol.78 (6), p.2283-2289</ispartof><rights>2017 International Society for Magnetic Resonance in Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c182t-eb545a371c294ef686eb46dc3cee1aef87dc796865701cec7c5026f2976cd6a33</citedby><cites>FETCH-LOGICAL-c182t-eb545a371c294ef686eb46dc3cee1aef87dc796865701cec7c5026f2976cd6a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28247427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stout, Jeffrey N</creatorcontrib><creatorcontrib>Tisdall, M Dylan</creatorcontrib><creatorcontrib>McDaniel, Patrick</creatorcontrib><creatorcontrib>Gagoski, Borjan</creatorcontrib><creatorcontrib>Bolar, Divya S</creatorcontrib><creatorcontrib>Grant, Patricia Ellen</creatorcontrib><creatorcontrib>Adalsteinsson, Elfar</creatorcontrib><title>Assessing the effects of subject motion on T 2 relaxation under spin tagging (TRUST) cerebral oxygenation measurements using volume navigators</title><title>Magnetic resonance in medicine</title><addtitle>Magn Reson Med</addtitle><description>Subject motion may cause errors in estimates of blood T
when using the T
-relaxation under spin tagging (TRUST) technique on noncompliant subjects like neonates. By incorporating 3D volume navigators (vNavs) into the TRUST pulse sequence, independent measurements of motion during scanning permit evaluation of these errors.
The effects of integrated vNavs on TRUST-based T
estimates were evaluated using simulations and in vivo subject data. Two subjects were scanned with the TRUST+vNav sequence during prescribed movements. Mean motion scores were derived from vNavs and TRUST images, along with a metric of exponential fit quality. Regression analysis was performed between T
estimates and mean motion scores. Also, motion scores were determined from independent neonatal scans.
vNavs negligibly affected venous blood T
estimates and better detected subject motion than fit quality metrics. Regression analysis showed that T
is biased upward by 4.1 ms per 1 mm of mean motion score. During neonatal scans, mean motion scores of 0.6 to 2.0 mm were detected.
Motion during TRUST causes an overestimate of T
, which suggests a cautious approach when comparing TRUST-based cerebral oxygenation measurements of noncompliant subjects. Magn Reson Med 78:2283-2289, 2017. © 2017 International Society for Magnetic Resonance in Medicine.</description><subject>Adult</subject><subject>Algorithms</subject><subject>Brain - diagnostic imaging</subject><subject>Computer Simulation</subject><subject>Female</subject><subject>Humans</subject><subject>Image Enhancement</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Imaging, Three-Dimensional</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Models, Statistical</subject><subject>Motion</subject><subject>Oximetry</subject><subject>Oxygen - chemistry</subject><subject>Regression Analysis</subject><subject>Reproducibility of Results</subject><subject>Young Adult</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kF1LwzAUhoMobk4v_AOSS3fRmaRp0l6OMT9gIGh3XdL0pHY07Ujasf0Jf7PdpsKBc3h5eA88CN1TMqOEsCfr7IwJQcUFGtOIsYBFCb9EYyI5CUKa8BG68X5DCEkSya_RiMWMS87kGH3PvQfvq6bE3RdgMAZ053FrsO_zzXBj23ZV2-BhUsywg1rt1SnpmwIc9tuqwZ0qy2PFY_qx_kynWIOD3Kkat_tDCc2Zt6B878BCMzzoTy93bd1bwI3aVaXqWudv0ZVRtYe73z1B6-dlungNVu8vb4v5KtA0Zl0AecQjFUqqWcLBiFhAzkWhQw1AFZhYFlomQxxJQjVoqSPChGGJFLoQKgwnaHru1a713oHJtq6yyh0ySrKj02xwmp2cDuzDmd32uYXin_yTGP4Ao2l1aw</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Stout, Jeffrey N</creator><creator>Tisdall, M Dylan</creator><creator>McDaniel, Patrick</creator><creator>Gagoski, Borjan</creator><creator>Bolar, Divya S</creator><creator>Grant, Patricia Ellen</creator><creator>Adalsteinsson, Elfar</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201712</creationdate><title>Assessing the effects of subject motion on T 2 relaxation under spin tagging (TRUST) cerebral oxygenation measurements using volume navigators</title><author>Stout, Jeffrey N ; Tisdall, M Dylan ; McDaniel, Patrick ; Gagoski, Borjan ; Bolar, Divya S ; Grant, Patricia Ellen ; Adalsteinsson, Elfar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c182t-eb545a371c294ef686eb46dc3cee1aef87dc796865701cec7c5026f2976cd6a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Algorithms</topic><topic>Brain - diagnostic imaging</topic><topic>Computer Simulation</topic><topic>Female</topic><topic>Humans</topic><topic>Image Enhancement</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Imaging, Three-Dimensional</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Models, Statistical</topic><topic>Motion</topic><topic>Oximetry</topic><topic>Oxygen - chemistry</topic><topic>Regression Analysis</topic><topic>Reproducibility of Results</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stout, Jeffrey N</creatorcontrib><creatorcontrib>Tisdall, M Dylan</creatorcontrib><creatorcontrib>McDaniel, Patrick</creatorcontrib><creatorcontrib>Gagoski, Borjan</creatorcontrib><creatorcontrib>Bolar, Divya S</creatorcontrib><creatorcontrib>Grant, Patricia Ellen</creatorcontrib><creatorcontrib>Adalsteinsson, Elfar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stout, Jeffrey N</au><au>Tisdall, M Dylan</au><au>McDaniel, Patrick</au><au>Gagoski, Borjan</au><au>Bolar, Divya S</au><au>Grant, Patricia Ellen</au><au>Adalsteinsson, Elfar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing the effects of subject motion on T 2 relaxation under spin tagging (TRUST) cerebral oxygenation measurements using volume navigators</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn Reson Med</addtitle><date>2017-12</date><risdate>2017</risdate><volume>78</volume><issue>6</issue><spage>2283</spage><epage>2289</epage><pages>2283-2289</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><abstract>Subject motion may cause errors in estimates of blood T
when using the T
-relaxation under spin tagging (TRUST) technique on noncompliant subjects like neonates. By incorporating 3D volume navigators (vNavs) into the TRUST pulse sequence, independent measurements of motion during scanning permit evaluation of these errors.
The effects of integrated vNavs on TRUST-based T
estimates were evaluated using simulations and in vivo subject data. Two subjects were scanned with the TRUST+vNav sequence during prescribed movements. Mean motion scores were derived from vNavs and TRUST images, along with a metric of exponential fit quality. Regression analysis was performed between T
estimates and mean motion scores. Also, motion scores were determined from independent neonatal scans.
vNavs negligibly affected venous blood T
estimates and better detected subject motion than fit quality metrics. Regression analysis showed that T
is biased upward by 4.1 ms per 1 mm of mean motion score. During neonatal scans, mean motion scores of 0.6 to 2.0 mm were detected.
Motion during TRUST causes an overestimate of T
, which suggests a cautious approach when comparing TRUST-based cerebral oxygenation measurements of noncompliant subjects. Magn Reson Med 78:2283-2289, 2017. © 2017 International Society for Magnetic Resonance in Medicine.</abstract><cop>United States</cop><pmid>28247427</pmid><doi>10.1002/mrm.26616</doi><tpages>7</tpages></addata></record> |
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| ispartof | Magnetic resonance in medicine, 2017-12, Vol.78 (6), p.2283-2289 |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Wiley Online Library Free Content |
| subjects | Adult Algorithms Brain - diagnostic imaging Computer Simulation Female Humans Image Enhancement Image Interpretation, Computer-Assisted Imaging, Three-Dimensional Magnetic Resonance Imaging Male Models, Statistical Motion Oximetry Oxygen - chemistry Regression Analysis Reproducibility of Results Young Adult |
| title | Assessing the effects of subject motion on T 2 relaxation under spin tagging (TRUST) cerebral oxygenation measurements using volume navigators |
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