Relative Concentrations of Proton MR Visible Neurochemicals in Gray and White Matter in Human Brain
The relative distributions of N‐acetylaspartate (NAA) + N‐acetylaspartylglutamate (NAAG), creatine + phosphocreatine (Cr/PCr), and choline (Cho) in the gray and white matter of human brain were determined by utilizing proton magnetic resonance spectroscopic imaging (SI). The SI data was processed us...
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| Veröffentlicht in: | Magnetic resonance in medicine 1995-06, Vol.33 (6), p.755-759 |
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| container_title | Magnetic resonance in medicine |
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| creator | Doyle, Timothy J. Bedell, Barry J. Narayana, Ponnada A. |
| description | The relative distributions of N‐acetylaspartate (NAA) + N‐acetylaspartylglutamate (NAAG), creatine + phosphocreatine (Cr/PCr), and choline (Cho) in the gray and white matter of human brain were determined by utilizing proton magnetic resonance spectroscopic imaging (SI). The SI data was processed using an automated spectroscopic image processing algorithm, and image segmentation was performed using a supervised technique. Linear regression analysis indicated that the NAA + NAAG (2.01 ppm) and Cr/PCr (3.02 ppm) peaks are greater in gray matter compared with white matter. The large intersubject variation observed in the Cho (3.20 ppm) resonance prevented the assessment of its regional distribution with confidence. |
| doi_str_mv | 10.1002/mrm.1910330603 |
| format | Article |
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The SI data was processed using an automated spectroscopic image processing algorithm, and image segmentation was performed using a supervised technique. Linear regression analysis indicated that the NAA + NAAG (2.01 ppm) and Cr/PCr (3.02 ppm) peaks are greater in gray matter compared with white matter. The large intersubject variation observed in the Cho (3.20 ppm) resonance prevented the assessment of its regional distribution with confidence.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.1910330603</identifier><identifier>PMID: 7651110</identifier><identifier>CODEN: MRMEEN</identifier><language>eng</language><publisher>Baltimore: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - analysis ; Biological and medical sciences ; brain ; Brain Chemistry ; Choline - analysis ; Creatine - analysis ; Dipeptides - analysis ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; MRI ; MRS ; Nervous system ; Neuropeptides - analysis ; Phosphocreatine - analysis ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; segmentation</subject><ispartof>Magnetic resonance in medicine, 1995-06, Vol.33 (6), p.755-759</ispartof><rights>Copyright © 1995 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4733-2da62f6c26135b9c194ee4bc038ef78bf1a0d41a4714d04e655753adf733edee3</citedby><cites>FETCH-LOGICAL-c4733-2da62f6c26135b9c194ee4bc038ef78bf1a0d41a4714d04e655753adf733edee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.1910330603$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.1910330603$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3546243$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7651110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Doyle, Timothy J.</creatorcontrib><creatorcontrib>Bedell, Barry J.</creatorcontrib><creatorcontrib>Narayana, Ponnada A.</creatorcontrib><title>Relative Concentrations of Proton MR Visible Neurochemicals in Gray and White Matter in Human Brain</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>The relative distributions of N‐acetylaspartate (NAA) + N‐acetylaspartylglutamate (NAAG), creatine + phosphocreatine (Cr/PCr), and choline (Cho) in the gray and white matter of human brain were determined by utilizing proton magnetic resonance spectroscopic imaging (SI). The SI data was processed using an automated spectroscopic image processing algorithm, and image segmentation was performed using a supervised technique. Linear regression analysis indicated that the NAA + NAAG (2.01 ppm) and Cr/PCr (3.02 ppm) peaks are greater in gray matter compared with white matter. The large intersubject variation observed in the Cho (3.20 ppm) resonance prevented the assessment of its regional distribution with confidence.</description><subject>Adult</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - analysis</subject><subject>Biological and medical sciences</subject><subject>brain</subject><subject>Brain Chemistry</subject><subject>Choline - analysis</subject><subject>Creatine - analysis</subject><subject>Dipeptides - analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MRI</subject><subject>MRS</subject><subject>Nervous system</subject><subject>Neuropeptides - analysis</subject><subject>Phosphocreatine - analysis</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>segmentation</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPAjEUhRujUXxs3Zl04Xawnb6YpaCCCaAhPpZNp3MnVJmOaQeVf-8QCMaVq5ubc777OAidU9KlhKRXVai6NKOEMSIJ20MdKtI0SUXG91GHKE4SRjN-hI5jfCOEZJnih-hQSUEpJR1kZ7AwjfsEPKi9Bd-Etqt9xHWJH0Pd1B5PZvjFRZcvAE9hGWo7h8pZs4jYeTwMZoWNL_Dr3DWAJ6ZpIKyF0bIyHveDcf4UHZStHc629QQ9390-DUbJ-GF4P7geJ5YrxpK0MDItpU0lZSLPbHs2AM8tYT0oVS8vqSEFp4YrygvCQQqhBDNF2cJQALAT1N3MtaGOMUCpP4KrTFhpSvQ6LN2GpX_DaoGLDfCxzCsodvZtOq1-udVNbB8ug_HWxZ2NCS5Tvh6TbWxfbgGrf5bqyWzy54Rkw7rYwPeONeFdS8WU0K_Toc76fDCW9EXfsB-MMZGk</recordid><startdate>199506</startdate><enddate>199506</enddate><creator>Doyle, Timothy J.</creator><creator>Bedell, Barry J.</creator><creator>Narayana, Ponnada A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199506</creationdate><title>Relative Concentrations of Proton MR Visible Neurochemicals in Gray and White Matter in Human Brain</title><author>Doyle, Timothy J. ; Bedell, Barry J. ; Narayana, Ponnada A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4733-2da62f6c26135b9c194ee4bc038ef78bf1a0d41a4714d04e655753adf733edee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - analysis</topic><topic>Biological and medical sciences</topic><topic>brain</topic><topic>Brain Chemistry</topic><topic>Choline - analysis</topic><topic>Creatine - analysis</topic><topic>Dipeptides - analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MRI</topic><topic>MRS</topic><topic>Nervous system</topic><topic>Neuropeptides - analysis</topic><topic>Phosphocreatine - analysis</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>segmentation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doyle, Timothy J.</creatorcontrib><creatorcontrib>Bedell, Barry J.</creatorcontrib><creatorcontrib>Narayana, Ponnada A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doyle, Timothy J.</au><au>Bedell, Barry J.</au><au>Narayana, Ponnada A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relative Concentrations of Proton MR Visible Neurochemicals in Gray and White Matter in Human Brain</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>1995-06</date><risdate>1995</risdate><volume>33</volume><issue>6</issue><spage>755</spage><epage>759</epage><pages>755-759</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>The relative distributions of N‐acetylaspartate (NAA) + N‐acetylaspartylglutamate (NAAG), creatine + phosphocreatine (Cr/PCr), and choline (Cho) in the gray and white matter of human brain were determined by utilizing proton magnetic resonance spectroscopic imaging (SI). The SI data was processed using an automated spectroscopic image processing algorithm, and image segmentation was performed using a supervised technique. Linear regression analysis indicated that the NAA + NAAG (2.01 ppm) and Cr/PCr (3.02 ppm) peaks are greater in gray matter compared with white matter. The large intersubject variation observed in the Cho (3.20 ppm) resonance prevented the assessment of its regional distribution with confidence.</abstract><cop>Baltimore</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>7651110</pmid><doi>10.1002/mrm.1910330603</doi><tpages>5</tpages></addata></record> |
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| ispartof | Magnetic resonance in medicine, 1995-06, Vol.33 (6), p.755-759 |
| issn | 0740-3194 1522-2594 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aspartic Acid - analogs & derivatives Aspartic Acid - analysis Biological and medical sciences brain Brain Chemistry Choline - analysis Creatine - analysis Dipeptides - analysis Female Humans Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Spectroscopy Male Medical sciences MRI MRS Nervous system Neuropeptides - analysis Phosphocreatine - analysis Radiodiagnosis. Nmr imagery. Nmr spectrometry segmentation |
| title | Relative Concentrations of Proton MR Visible Neurochemicals in Gray and White Matter in Human Brain |
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