In vivo proton nuclear magnetic resonance imaging and spectroscopy studies of halocarbon-induced liver damage
Proton magnetic resonance imaging and localized NMR spectroscopy were used to study the rat liver in situ. Respiratory gating was used in both the imaging and the localized spectroscopy studies to control for the movement of the upper abdomen of the rat during breathing. After administration of carb...
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| Veröffentlicht in: | Magnet. Reson. Med.; (United States) 1989-02, Vol.9 (2), p.229-239 |
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| creator | Brauer, Manfred Towner, Rheal A. Renaud, Ian Janzen, Edward G. Foxall, David L. |
| description | Proton magnetic resonance imaging and localized NMR spectroscopy were used to study the rat liver in situ. Respiratory gating was used in both the imaging and the localized spectroscopy studies to control for the movement of the upper abdomen of the rat during breathing. After administration of carbon tetrachloride, bromotrichloromethane, or halothane, localized regions of high proton signal intensity were observed in the NMR images of the liver. Localized (VOSY) proton NMR spectra from within these regions indicated that the increase in a signal intensity was due to a longer T2 relaxation time for the water resonance, indicating acute edema in the region of tissue damage. © 1989 Academic Press, Inc. |
| doi_str_mv | 10.1002/mrm.1910090208 |
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Respiratory gating was used in both the imaging and the localized spectroscopy studies to control for the movement of the upper abdomen of the rat during breathing. After administration of carbon tetrachloride, bromotrichloromethane, or halothane, localized regions of high proton signal intensity were observed in the NMR images of the liver. Localized (VOSY) proton NMR spectra from within these regions indicated that the increase in a signal intensity was due to a longer T2 relaxation time for the water resonance, indicating acute edema in the region of tissue damage. © 1989 Academic Press, Inc.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.1910090208</identifier><identifier>PMID: 2541304</identifier><identifier>CODEN: MRMEEN</identifier><language>eng</language><publisher>Baltimore: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>550600 - Medicine ; Administration, Inhalation ; ANIMALS ; BARYONS ; Biological and medical sciences ; BODY ; Bromotrichloromethane - administration & dosage ; Bromotrichloromethane - toxicity ; CARBON TETRACHLORIDE ; Carbon Tetrachloride - administration & dosage ; Carbon Tetrachloride - toxicity ; CHLORINATED ALIPHATIC HYDROCARBONS ; CHLOROFORM ; Chloroform - analogs & derivatives ; DIAGNOSTIC TECHNIQUES ; DIGESTIVE SYSTEM ; EDEMA ; ELEMENTARY PARTICLES ; FERMIONS ; GLANDS ; HADRONS ; HALOGENATED ALIPHATIC HYDROCARBONS ; Halothane - administration & dosage ; Halothane - toxicity ; HYDROGEN COMPOUNDS ; IN VIVO ; Investigative techniques, diagnostic techniques (general aspects) ; LIPIDS ; LIVER ; Liver - drug effects ; Liver - pathology ; MAGNETIC RESONANCE ; Magnetic Resonance Spectroscopy - methods ; MAMMALS ; Medical sciences ; NMR IMAGING ; NMR SPECTRA ; NUCLEAR MAGNETIC RESONANCE ; NUCLEONS ; ORGANIC CHLORINE COMPOUNDS ; ORGANIC COMPOUNDS ; ORGANIC HALOGEN COMPOUNDS ; ORGANS ; OXYGEN COMPOUNDS ; PATHOLOGICAL CHANGES ; PROTONS ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; RADIOLOGY AND NUCLEAR MEDICINE ; RATS ; RESONANCE ; RODENTS ; SPECTRA ; SYMPTOMS ; VERTEBRATES ; WATER</subject><ispartof>Magnet. Reson. Med.; (United States), 1989-02, Vol.9 (2), p.229-239</ispartof><rights>Copyright © 1989 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4168-c3d2f6edd9e1fab5a3b8af5ed233460a9e38366a8324011eaefab316fda0c9743</citedby><cites>FETCH-LOGICAL-c4168-c3d2f6edd9e1fab5a3b8af5ed233460a9e38366a8324011eaefab316fda0c9743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.1910090208$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.1910090208$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19599443$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2541304$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5997544$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Brauer, Manfred</creatorcontrib><creatorcontrib>Towner, Rheal A.</creatorcontrib><creatorcontrib>Renaud, Ian</creatorcontrib><creatorcontrib>Janzen, Edward G.</creatorcontrib><creatorcontrib>Foxall, David L.</creatorcontrib><creatorcontrib>Univ. of Guelph, Ontario (Canada)</creatorcontrib><title>In vivo proton nuclear magnetic resonance imaging and spectroscopy studies of halocarbon-induced liver damage</title><title>Magnet. Reson. Med.; (United States)</title><addtitle>Magn. Reson. Med</addtitle><description>Proton magnetic resonance imaging and localized NMR spectroscopy were used to study the rat liver in situ. Respiratory gating was used in both the imaging and the localized spectroscopy studies to control for the movement of the upper abdomen of the rat during breathing. After administration of carbon tetrachloride, bromotrichloromethane, or halothane, localized regions of high proton signal intensity were observed in the NMR images of the liver. Localized (VOSY) proton NMR spectra from within these regions indicated that the increase in a signal intensity was due to a longer T2 relaxation time for the water resonance, indicating acute edema in the region of tissue damage. © 1989 Academic Press, Inc.</description><subject>550600 - Medicine</subject><subject>Administration, Inhalation</subject><subject>ANIMALS</subject><subject>BARYONS</subject><subject>Biological and medical sciences</subject><subject>BODY</subject><subject>Bromotrichloromethane - administration & dosage</subject><subject>Bromotrichloromethane - toxicity</subject><subject>CARBON TETRACHLORIDE</subject><subject>Carbon Tetrachloride - administration & dosage</subject><subject>Carbon Tetrachloride - toxicity</subject><subject>CHLORINATED ALIPHATIC HYDROCARBONS</subject><subject>CHLOROFORM</subject><subject>Chloroform - analogs & derivatives</subject><subject>DIAGNOSTIC TECHNIQUES</subject><subject>DIGESTIVE SYSTEM</subject><subject>EDEMA</subject><subject>ELEMENTARY PARTICLES</subject><subject>FERMIONS</subject><subject>GLANDS</subject><subject>HADRONS</subject><subject>HALOGENATED ALIPHATIC HYDROCARBONS</subject><subject>Halothane - administration & dosage</subject><subject>Halothane - toxicity</subject><subject>HYDROGEN COMPOUNDS</subject><subject>IN VIVO</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>LIPIDS</subject><subject>LIVER</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>MAGNETIC RESONANCE</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>MAMMALS</subject><subject>Medical sciences</subject><subject>NMR IMAGING</subject><subject>NMR SPECTRA</subject><subject>NUCLEAR MAGNETIC RESONANCE</subject><subject>NUCLEONS</subject><subject>ORGANIC CHLORINE COMPOUNDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC HALOGEN COMPOUNDS</subject><subject>ORGANS</subject><subject>OXYGEN COMPOUNDS</subject><subject>PATHOLOGICAL CHANGES</subject><subject>PROTONS</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RATS</subject><subject>RESONANCE</subject><subject>RODENTS</subject><subject>SPECTRA</subject><subject>SYMPTOMS</subject><subject>VERTEBRATES</subject><subject>WATER</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtvEzEQxi0EKqFw5YZkIXHc4Nc-fERRCZVaQIjH0ZrYs61h117Zm0D-e1xt1IoTJ488v2--mY-Ql5ytOWPi7ZjGNdel1Eyw7hFZ8VqIStRaPSYr1ipWSa7VU_Is55-sULpVZ-RM1IpLplZkvAz04A-RTinOMdCwtwNCoiPcBJy9pQlzDBAsUl_-fLihEBzNE9o5xWzjdKR53juPmcae3sIQLaRdDJUPbm_R0cEfMFEHRY3PyZMehowvTu85-fb-4uvmQ3X1aXu5eXdVWcWbrrLSib5B5zTyHnY1yF0HfY1OSKkaBhplJ5sGOikU4xwBCyV50ztgthwoz8nrZW7MszfZ-hntrY0hlK1NXTKo1R20XiBbDskJezOlcmM6Gs7MXbamZGsesi2CV4tg2u9GdPf4KczSf3PqQ7Yw9KnE5vPDVF2ci2_h9ML99gMe_-Nqrr9c_7NDtWh9nvHPvRbSL9O0sq3Nj49bIz9vxLZtOvNd_gV2T6Ob</recordid><startdate>198902</startdate><enddate>198902</enddate><creator>Brauer, Manfred</creator><creator>Towner, Rheal A.</creator><creator>Renaud, Ian</creator><creator>Janzen, Edward G.</creator><creator>Foxall, David L.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>198902</creationdate><title>In vivo proton nuclear magnetic resonance imaging and spectroscopy studies of halocarbon-induced liver damage</title><author>Brauer, Manfred ; Towner, Rheal A. ; Renaud, Ian ; Janzen, Edward G. ; Foxall, David L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4168-c3d2f6edd9e1fab5a3b8af5ed233460a9e38366a8324011eaefab316fda0c9743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>550600 - Medicine</topic><topic>Administration, Inhalation</topic><topic>ANIMALS</topic><topic>BARYONS</topic><topic>Biological and medical sciences</topic><topic>BODY</topic><topic>Bromotrichloromethane - administration & dosage</topic><topic>Bromotrichloromethane - toxicity</topic><topic>CARBON TETRACHLORIDE</topic><topic>Carbon Tetrachloride - administration & dosage</topic><topic>Carbon Tetrachloride - toxicity</topic><topic>CHLORINATED ALIPHATIC HYDROCARBONS</topic><topic>CHLOROFORM</topic><topic>Chloroform - analogs & derivatives</topic><topic>DIAGNOSTIC TECHNIQUES</topic><topic>DIGESTIVE SYSTEM</topic><topic>EDEMA</topic><topic>ELEMENTARY PARTICLES</topic><topic>FERMIONS</topic><topic>GLANDS</topic><topic>HADRONS</topic><topic>HALOGENATED ALIPHATIC HYDROCARBONS</topic><topic>Halothane - administration & dosage</topic><topic>Halothane - toxicity</topic><topic>HYDROGEN COMPOUNDS</topic><topic>IN VIVO</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>LIPIDS</topic><topic>LIVER</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>MAGNETIC RESONANCE</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>MAMMALS</topic><topic>Medical sciences</topic><topic>NMR IMAGING</topic><topic>NMR SPECTRA</topic><topic>NUCLEAR MAGNETIC RESONANCE</topic><topic>NUCLEONS</topic><topic>ORGANIC CHLORINE COMPOUNDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC HALOGEN COMPOUNDS</topic><topic>ORGANS</topic><topic>OXYGEN COMPOUNDS</topic><topic>PATHOLOGICAL CHANGES</topic><topic>PROTONS</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RATS</topic><topic>RESONANCE</topic><topic>RODENTS</topic><topic>SPECTRA</topic><topic>SYMPTOMS</topic><topic>VERTEBRATES</topic><topic>WATER</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brauer, Manfred</creatorcontrib><creatorcontrib>Towner, Rheal A.</creatorcontrib><creatorcontrib>Renaud, Ian</creatorcontrib><creatorcontrib>Janzen, Edward G.</creatorcontrib><creatorcontrib>Foxall, David L.</creatorcontrib><creatorcontrib>Univ. of Guelph, Ontario (Canada)</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Magnet. Reson. Med.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brauer, Manfred</au><au>Towner, Rheal A.</au><au>Renaud, Ian</au><au>Janzen, Edward G.</au><au>Foxall, David L.</au><aucorp>Univ. of Guelph, Ontario (Canada)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo proton nuclear magnetic resonance imaging and spectroscopy studies of halocarbon-induced liver damage</atitle><jtitle>Magnet. Reson. Med.; (United States)</jtitle><addtitle>Magn. Reson. Med</addtitle><date>1989-02</date><risdate>1989</risdate><volume>9</volume><issue>2</issue><spage>229</spage><epage>239</epage><pages>229-239</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>Proton magnetic resonance imaging and localized NMR spectroscopy were used to study the rat liver in situ. Respiratory gating was used in both the imaging and the localized spectroscopy studies to control for the movement of the upper abdomen of the rat during breathing. After administration of carbon tetrachloride, bromotrichloromethane, or halothane, localized regions of high proton signal intensity were observed in the NMR images of the liver. Localized (VOSY) proton NMR spectra from within these regions indicated that the increase in a signal intensity was due to a longer T2 relaxation time for the water resonance, indicating acute edema in the region of tissue damage. © 1989 Academic Press, Inc.</abstract><cop>Baltimore</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2541304</pmid><doi>10.1002/mrm.1910090208</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0740-3194 |
| ispartof | Magnet. Reson. Med.; (United States), 1989-02, Vol.9 (2), p.229-239 |
| issn | 0740-3194 1522-2594 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_mrm_1910090208 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | 550600 - Medicine Administration, Inhalation ANIMALS BARYONS Biological and medical sciences BODY Bromotrichloromethane - administration & dosage Bromotrichloromethane - toxicity CARBON TETRACHLORIDE Carbon Tetrachloride - administration & dosage Carbon Tetrachloride - toxicity CHLORINATED ALIPHATIC HYDROCARBONS CHLOROFORM Chloroform - analogs & derivatives DIAGNOSTIC TECHNIQUES DIGESTIVE SYSTEM EDEMA ELEMENTARY PARTICLES FERMIONS GLANDS HADRONS HALOGENATED ALIPHATIC HYDROCARBONS Halothane - administration & dosage Halothane - toxicity HYDROGEN COMPOUNDS IN VIVO Investigative techniques, diagnostic techniques (general aspects) LIPIDS LIVER Liver - drug effects Liver - pathology MAGNETIC RESONANCE Magnetic Resonance Spectroscopy - methods MAMMALS Medical sciences NMR IMAGING NMR SPECTRA NUCLEAR MAGNETIC RESONANCE NUCLEONS ORGANIC CHLORINE COMPOUNDS ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS ORGANS OXYGEN COMPOUNDS PATHOLOGICAL CHANGES PROTONS Radiodiagnosis. Nmr imagery. Nmr spectrometry RADIOLOGY AND NUCLEAR MEDICINE RATS RESONANCE RODENTS SPECTRA SYMPTOMS VERTEBRATES WATER |
| title | In vivo proton nuclear magnetic resonance imaging and spectroscopy studies of halocarbon-induced liver damage |
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