MRI mapping of cerebrovascular reactivity using square wave changes in end‐tidal PCO 2
Cerebrovascular reactivity can be quantified by correlating blood oxygen level dependent (BOLD) signal intensity with changes in end‐tidal partial pressure of carbon dioxide (PCO 2 ). Four 3‐min cycles of high and low PCO 2 were induced in three subjects, each cycle containing a steady PCO 2 level l...
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| Veröffentlicht in: | Magnetic resonance in medicine 2001-06, Vol.45 (6), p.1011-1013 |
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| container_title | Magnetic resonance in medicine |
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| creator | Vesely, Alex Sasano, Hiroshi Volgyesi, George Somogyi, Ron Tesler, Janet Fedorko, Ludwik Grynspan, Jonathan Crawley, Adrian Fisher, Joseph A. Mikulis, David |
| description | Cerebrovascular reactivity can be quantified by correlating blood oxygen level dependent (BOLD) signal intensity with changes in end‐tidal partial pressure of carbon dioxide (PCO
2
). Four 3‐min cycles of high and low PCO
2
were induced in three subjects, each cycle containing a steady PCO
2
level lasting at least 60 sec. The BOLD signal closely followed the end‐tidal PCO
2
. The mean MRI signal intensity difference between high and low PCO
2
(i.e., cerebrovascular reactivity) was 4.0 ± 3.4% for gray matter and 0.0 ± 2.0% for white matter. This is the first demonstration of the application of a controlled reproducible physiologic stimulus, i.e., alternating steady state levels of PCO
2
, to the quantification of cerebrovascular reactivity. Magn Reson Med 45:1011–1013, 2001. © 2001 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/mrm.1134 |
| format | Article |
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2
). Four 3‐min cycles of high and low PCO
2
were induced in three subjects, each cycle containing a steady PCO
2
level lasting at least 60 sec. The BOLD signal closely followed the end‐tidal PCO
2
. The mean MRI signal intensity difference between high and low PCO
2
(i.e., cerebrovascular reactivity) was 4.0 ± 3.4% for gray matter and 0.0 ± 2.0% for white matter. This is the first demonstration of the application of a controlled reproducible physiologic stimulus, i.e., alternating steady state levels of PCO
2
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2
). Four 3‐min cycles of high and low PCO
2
were induced in three subjects, each cycle containing a steady PCO
2
level lasting at least 60 sec. The BOLD signal closely followed the end‐tidal PCO
2
. The mean MRI signal intensity difference between high and low PCO
2
(i.e., cerebrovascular reactivity) was 4.0 ± 3.4% for gray matter and 0.0 ± 2.0% for white matter. This is the first demonstration of the application of a controlled reproducible physiologic stimulus, i.e., alternating steady state levels of PCO
2
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2
). Four 3‐min cycles of high and low PCO
2
were induced in three subjects, each cycle containing a steady PCO
2
level lasting at least 60 sec. The BOLD signal closely followed the end‐tidal PCO
2
. The mean MRI signal intensity difference between high and low PCO
2
(i.e., cerebrovascular reactivity) was 4.0 ± 3.4% for gray matter and 0.0 ± 2.0% for white matter. This is the first demonstration of the application of a controlled reproducible physiologic stimulus, i.e., alternating steady state levels of PCO
2
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| title | MRI mapping of cerebrovascular reactivity using square wave changes in end‐tidal PCO 2 |
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