Nonmetastatic thoracic neuroblastomas: A review of 40 cases
From 1982 to 1987, 40 children with nonmetastatic thoracic neuroblastoma were treated with the same therapeutic regimen. According to TNM staging, there were 11 CS I,19 CS II, and 10 CS III. All patients underwent surgery; 30 had primary surgical excision; in 10 whose tumors were deemed unresectable...
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| Veröffentlicht in: | Medical and pediatric oncology 1991, Vol.19 (4), p.253-257 |
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| container_title | Medical and pediatric oncology |
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| creator | Rubie, Hervé Hartmann, Olivier Giron, Alain Lemoine, Georges Gruner, Max Brugieres, Laurence Valteau-Couanet, Dominique Robert, Alain Lemerle, Jean |
| description | From 1982 to 1987, 40 children with nonmetastatic thoracic neuroblastoma were treated with the same therapeutic regimen. According to TNM staging, there were 11 CS I,19 CS II, and 10 CS III. All patients underwent surgery; 30 had primary surgical excision; in 10 whose tumors were deemed unresectable, surgery was delayed until after a trial of chemotherapy. Operation was completed by several courses of chemotherapy in case of microscopic residual disease or regional lymph node involvement; radiotherapy was delivered in case of gross residual disease. Using this therapeutic approach, EFS is 92% with a median follow‐up of 40 months. Severe complications were rare and sequellae appear to be related to the disease, i.e., neurologic consequences of cord compression. |
| doi_str_mv | 10.1002/mpo.2950190408 |
| format | Article |
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According to TNM staging, there were 11 CS I,19 CS II, and 10 CS III. All patients underwent surgery; 30 had primary surgical excision; in 10 whose tumors were deemed unresectable, surgery was delayed until after a trial of chemotherapy. Operation was completed by several courses of chemotherapy in case of microscopic residual disease or regional lymph node involvement; radiotherapy was delivered in case of gross residual disease. Using this therapeutic approach, EFS is 92% with a median follow‐up of 40 months. Severe complications were rare and sequellae appear to be related to the disease, i.e., neurologic consequences of cord compression.</description><identifier>ISSN: 0098-1532</identifier><identifier>EISSN: 1096-911X</identifier><identifier>DOI: 10.1002/mpo.2950190408</identifier><identifier>PMID: 2056969</identifier><identifier>CODEN: MPONDB</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; chemotherapy ; Child ; Child, Preschool ; Combined Modality Therapy ; Cyclophosphamide - administration & dosage ; Doxorubicin - administration & dosage ; Female ; Follow-Up Studies ; Humans ; Infant ; Infant, Newborn ; Male ; Medical sciences ; Neoplasm Staging ; Neuroblastoma - mortality ; Neuroblastoma - pathology ; Neuroblastoma - secondary ; Neuroblastoma - therapy ; Neurology ; Radiotherapy Dosage ; surgery ; Survival Rate ; Thoracic Neoplasms - mortality ; Thoracic Neoplasms - pathology ; Thoracic Neoplasms - therapy ; thoracic neuroblastoma ; Vincristine - administration & dosage</subject><ispartof>Medical and pediatric oncology, 1991, Vol.19 (4), p.253-257</ispartof><rights>Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1992 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4078-493bb174d84755c2867852100949d63c8cd9d89c36f476fbe67d4e0429f2f9483</citedby><cites>FETCH-LOGICAL-c4078-493bb174d84755c2867852100949d63c8cd9d89c36f476fbe67d4e0429f2f9483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmpo.2950190408$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmpo.2950190408$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5474844$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2056969$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rubie, Hervé</creatorcontrib><creatorcontrib>Hartmann, Olivier</creatorcontrib><creatorcontrib>Giron, Alain</creatorcontrib><creatorcontrib>Lemoine, Georges</creatorcontrib><creatorcontrib>Gruner, Max</creatorcontrib><creatorcontrib>Brugieres, Laurence</creatorcontrib><creatorcontrib>Valteau-Couanet, Dominique</creatorcontrib><creatorcontrib>Robert, Alain</creatorcontrib><creatorcontrib>Lemerle, Jean</creatorcontrib><title>Nonmetastatic thoracic neuroblastomas: A review of 40 cases</title><title>Medical and pediatric oncology</title><addtitle>Med. Pediatr. Oncol</addtitle><description>From 1982 to 1987, 40 children with nonmetastatic thoracic neuroblastoma were treated with the same therapeutic regimen. According to TNM staging, there were 11 CS I,19 CS II, and 10 CS III. All patients underwent surgery; 30 had primary surgical excision; in 10 whose tumors were deemed unresectable, surgery was delayed until after a trial of chemotherapy. Operation was completed by several courses of chemotherapy in case of microscopic residual disease or regional lymph node involvement; radiotherapy was delivered in case of gross residual disease. Using this therapeutic approach, EFS is 92% with a median follow‐up of 40 months. Severe complications were rare and sequellae appear to be related to the disease, i.e., neurologic consequences of cord compression.</description><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>chemotherapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Combined Modality Therapy</subject><subject>Cyclophosphamide - administration & dosage</subject><subject>Doxorubicin - administration & dosage</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neoplasm Staging</subject><subject>Neuroblastoma - mortality</subject><subject>Neuroblastoma - pathology</subject><subject>Neuroblastoma - secondary</subject><subject>Neuroblastoma - therapy</subject><subject>Neurology</subject><subject>Radiotherapy Dosage</subject><subject>surgery</subject><subject>Survival Rate</subject><subject>Thoracic Neoplasms - mortality</subject><subject>Thoracic Neoplasms - pathology</subject><subject>Thoracic Neoplasms - therapy</subject><subject>thoracic neuroblastoma</subject><subject>Vincristine - administration & dosage</subject><issn>0098-1532</issn><issn>1096-911X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUE1PwkAQ3RgNInr1ZtKD1-Juu1-jJ0MUjAiYaDBeNtvtNlZbSnaLyL-3pgTjydN8vTfz5iF0SnCfYBxdlMuqHwHDBDDFcg91CQYeAiEv-6iLMciQsDg6REfev-OmBiE7qBNhxoFDF11NqkVpa-1rXecmqN8qp02TLOzKVUnR9KtS-8vgOnD2M7froMoCigOjvfXH6CDThbcn29hDz7c3T4NROJ4O7wbX49BQLGRIIU4SImgqqWDMRJILyaJGPFBIeWykSSGVYGKeUcGzxHKRUotpBFmUAZVxD_XbvcZV3jubqaXLS-02imD1Y4JqTFC_JjSEs5awXCWlTXfw7dfN_Hw7197oInN6YXK_gzEqqKS0gUELW-eF3fxzVD3Mpn8khC0397X92nG1-1BcxIKp-WSoZvdsBK-Pc8Xib4nXgs0</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>Rubie, Hervé</creator><creator>Hartmann, Olivier</creator><creator>Giron, Alain</creator><creator>Lemoine, Georges</creator><creator>Gruner, Max</creator><creator>Brugieres, Laurence</creator><creator>Valteau-Couanet, Dominique</creator><creator>Robert, Alain</creator><creator>Lemerle, Jean</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1991</creationdate><title>Nonmetastatic thoracic neuroblastomas: A review of 40 cases</title><author>Rubie, Hervé ; Hartmann, Olivier ; Giron, Alain ; Lemoine, Georges ; Gruner, Max ; Brugieres, Laurence ; Valteau-Couanet, Dominique ; Robert, Alain ; Lemerle, Jean</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4078-493bb174d84755c2867852100949d63c8cd9d89c36f476fbe67d4e0429f2f9483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Antineoplastic Combined Chemotherapy Protocols - adverse effects</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>chemotherapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Combined Modality Therapy</topic><topic>Cyclophosphamide - administration & dosage</topic><topic>Doxorubicin - administration & dosage</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neoplasm Staging</topic><topic>Neuroblastoma - mortality</topic><topic>Neuroblastoma - pathology</topic><topic>Neuroblastoma - secondary</topic><topic>Neuroblastoma - therapy</topic><topic>Neurology</topic><topic>Radiotherapy Dosage</topic><topic>surgery</topic><topic>Survival Rate</topic><topic>Thoracic Neoplasms - mortality</topic><topic>Thoracic Neoplasms - pathology</topic><topic>Thoracic Neoplasms - therapy</topic><topic>thoracic neuroblastoma</topic><topic>Vincristine - administration & dosage</topic><toplevel>online_resources</toplevel><creatorcontrib>Rubie, Hervé</creatorcontrib><creatorcontrib>Hartmann, Olivier</creatorcontrib><creatorcontrib>Giron, Alain</creatorcontrib><creatorcontrib>Lemoine, Georges</creatorcontrib><creatorcontrib>Gruner, Max</creatorcontrib><creatorcontrib>Brugieres, Laurence</creatorcontrib><creatorcontrib>Valteau-Couanet, Dominique</creatorcontrib><creatorcontrib>Robert, Alain</creatorcontrib><creatorcontrib>Lemerle, Jean</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Medical and pediatric oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rubie, Hervé</au><au>Hartmann, Olivier</au><au>Giron, Alain</au><au>Lemoine, Georges</au><au>Gruner, Max</au><au>Brugieres, Laurence</au><au>Valteau-Couanet, Dominique</au><au>Robert, Alain</au><au>Lemerle, Jean</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nonmetastatic thoracic neuroblastomas: A review of 40 cases</atitle><jtitle>Medical and pediatric oncology</jtitle><addtitle>Med. Pediatr. Oncol</addtitle><date>1991</date><risdate>1991</risdate><volume>19</volume><issue>4</issue><spage>253</spage><epage>257</epage><pages>253-257</pages><issn>0098-1532</issn><eissn>1096-911X</eissn><coden>MPONDB</coden><abstract>From 1982 to 1987, 40 children with nonmetastatic thoracic neuroblastoma were treated with the same therapeutic regimen. According to TNM staging, there were 11 CS I,19 CS II, and 10 CS III. All patients underwent surgery; 30 had primary surgical excision; in 10 whose tumors were deemed unresectable, surgery was delayed until after a trial of chemotherapy. Operation was completed by several courses of chemotherapy in case of microscopic residual disease or regional lymph node involvement; radiotherapy was delivered in case of gross residual disease. Using this therapeutic approach, EFS is 92% with a median follow‐up of 40 months. 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| fulltext | fulltext |
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| ispartof | Medical and pediatric oncology, 1991, Vol.19 (4), p.253-257 |
| issn | 0098-1532 1096-911X |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_mpo_2950190408 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences chemotherapy Child Child, Preschool Combined Modality Therapy Cyclophosphamide - administration & dosage Doxorubicin - administration & dosage Female Follow-Up Studies Humans Infant Infant, Newborn Male Medical sciences Neoplasm Staging Neuroblastoma - mortality Neuroblastoma - pathology Neuroblastoma - secondary Neuroblastoma - therapy Neurology Radiotherapy Dosage surgery Survival Rate Thoracic Neoplasms - mortality Thoracic Neoplasms - pathology Thoracic Neoplasms - therapy thoracic neuroblastoma Vincristine - administration & dosage |
| title | Nonmetastatic thoracic neuroblastomas: A review of 40 cases |
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