The Revised D-A-CH-Reference Values for the Intake of Vitamin B 12 : Prevention of Deficiency and Beyond
The nutrition societies of Germany, Austria, and Switzerland are the joint editors of the "D-A-CH reference values for nutrient intake", which are revised regularly. By reviewing vitamin-B -related biomarker studies, the reference values for vitamin B were revised in 2018. For adults, the...
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| Veröffentlicht in: | Molecular nutrition & food research 2019-03, Vol.63 (6), p.e1801178 |
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| creator | Ströhle, Alexander Richter, Margrit González-Gross, Marcela Neuhäuser-Berthold, Monika Wagner, Karl-Heinz Leschik-Bonnet, Eva Egert, Sarah |
| description | The nutrition societies of Germany, Austria, and Switzerland are the joint editors of the "D-A-CH reference values for nutrient intake", which are revised regularly.
By reviewing vitamin-B
-related biomarker studies, the reference values for vitamin B
were revised in 2018. For adults, the estimated intake is based on the adequate serum concentrations of holotranscobalamin and methylmalonic acid. The estimated values for children and adolescents are extrapolated from the adult reference value by considering differences in body mass, an allometric exponent, and growth factors. For infants below 4 months of age, an estimated value is set based on the vitamin B
intake via breast milk. The reference values for pregnant and lactating women consider the requirements for the fetus and for loss via breast milk. The estimated values for vitamin B
intake for infants, children, and adolescents range from 0.5 to 4.0 µg d
. For adults, the estimated values are set at 4.0 µg d
, and for pregnant and lactating women, they are set at 4.5 and 5.5 µg d
, respectively.
Based on the data of several vitamin B
status biomarkers studies, the reference value for vitamin B
intake for adults is raised from 3.0 to 4.0 µg d
. |
| doi_str_mv | 10.1002/mnfr.201801178 |
| format | Article |
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By reviewing vitamin-B
-related biomarker studies, the reference values for vitamin B
were revised in 2018. For adults, the estimated intake is based on the adequate serum concentrations of holotranscobalamin and methylmalonic acid. The estimated values for children and adolescents are extrapolated from the adult reference value by considering differences in body mass, an allometric exponent, and growth factors. For infants below 4 months of age, an estimated value is set based on the vitamin B
intake via breast milk. The reference values for pregnant and lactating women consider the requirements for the fetus and for loss via breast milk. The estimated values for vitamin B
intake for infants, children, and adolescents range from 0.5 to 4.0 µg d
. For adults, the estimated values are set at 4.0 µg d
, and for pregnant and lactating women, they are set at 4.5 and 5.5 µg d
, respectively.
Based on the data of several vitamin B
status biomarkers studies, the reference value for vitamin B
intake for adults is raised from 3.0 to 4.0 µg d
.</description><identifier>ISSN: 1613-4125</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.201801178</identifier><identifier>PMID: 30657638</identifier><language>eng</language><publisher>Germany</publisher><subject>Adolescent ; Adult ; Biological Availability ; Child ; Child, Preschool ; Female ; Homocysteine - blood ; Humans ; Infant ; Male ; Pregnancy ; Reference Values ; Vitamin B 12 - blood ; Vitamin B 12 - pharmacokinetics ; Vitamin B 12 Deficiency - blood ; Vitamin B 12 Deficiency - prevention & control ; Young Adult</subject><ispartof>Molecular nutrition & food research, 2019-03, Vol.63 (6), p.e1801178</ispartof><rights>2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c177t-c2789c66caf6483a54f86fdbca7a2e0bedc9a7e3f5a35aa99605e097cb7f59e03</citedby><cites>FETCH-LOGICAL-c177t-c2789c66caf6483a54f86fdbca7a2e0bedc9a7e3f5a35aa99605e097cb7f59e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30657638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ströhle, Alexander</creatorcontrib><creatorcontrib>Richter, Margrit</creatorcontrib><creatorcontrib>González-Gross, Marcela</creatorcontrib><creatorcontrib>Neuhäuser-Berthold, Monika</creatorcontrib><creatorcontrib>Wagner, Karl-Heinz</creatorcontrib><creatorcontrib>Leschik-Bonnet, Eva</creatorcontrib><creatorcontrib>Egert, Sarah</creatorcontrib><creatorcontrib>German Nutrition Society (DGE)</creatorcontrib><creatorcontrib>for the German Nutrition Society (DGE)</creatorcontrib><title>The Revised D-A-CH-Reference Values for the Intake of Vitamin B 12 : Prevention of Deficiency and Beyond</title><title>Molecular nutrition & food research</title><addtitle>Mol Nutr Food Res</addtitle><description>The nutrition societies of Germany, Austria, and Switzerland are the joint editors of the "D-A-CH reference values for nutrient intake", which are revised regularly.
By reviewing vitamin-B
-related biomarker studies, the reference values for vitamin B
were revised in 2018. For adults, the estimated intake is based on the adequate serum concentrations of holotranscobalamin and methylmalonic acid. The estimated values for children and adolescents are extrapolated from the adult reference value by considering differences in body mass, an allometric exponent, and growth factors. For infants below 4 months of age, an estimated value is set based on the vitamin B
intake via breast milk. The reference values for pregnant and lactating women consider the requirements for the fetus and for loss via breast milk. The estimated values for vitamin B
intake for infants, children, and adolescents range from 0.5 to 4.0 µg d
. For adults, the estimated values are set at 4.0 µg d
, and for pregnant and lactating women, they are set at 4.5 and 5.5 µg d
, respectively.
Based on the data of several vitamin B
status biomarkers studies, the reference value for vitamin B
intake for adults is raised from 3.0 to 4.0 µg d
.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological Availability</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Pregnancy</subject><subject>Reference Values</subject><subject>Vitamin B 12 - blood</subject><subject>Vitamin B 12 - pharmacokinetics</subject><subject>Vitamin B 12 Deficiency - blood</subject><subject>Vitamin B 12 Deficiency - prevention & control</subject><subject>Young Adult</subject><issn>1613-4125</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kFtrwjAYhsPYmM7tdpcjf6AuhyZpd-dhB0HYEOdtSdMvmM2mklTBf2_Fzav3g_fwwYPQIyVDSgh7rr0NQ0ZoRihV2RXqU0l5klLOry83Ez10F-MPIZyylN-iHidSKMmzPlov14AXsHcRKjxNRsnkI1mAhQDeAF7pzQ4itk3AbZeb-Vb_Am4sXrlW187jMaYMv-CvAHvwrWv8yZyCdcZ1AwesfYXHcGh8dY9urN5EePjTAfp-e1123-af77PJaJ4YqlSbGKay3EhptJVpxrVIbSZtVRqtNANSQmVyrYBbobnQOs8lEUByZUplRQ6ED9DwvGtCE2MAW2yDq3U4FJQUJ2TFCVlxQdYVns6F7a6sobrE_xnxI68uZsY</recordid><startdate>201903</startdate><enddate>201903</enddate><creator>Ströhle, Alexander</creator><creator>Richter, Margrit</creator><creator>González-Gross, Marcela</creator><creator>Neuhäuser-Berthold, Monika</creator><creator>Wagner, Karl-Heinz</creator><creator>Leschik-Bonnet, Eva</creator><creator>Egert, Sarah</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201903</creationdate><title>The Revised D-A-CH-Reference Values for the Intake of Vitamin B 12 : Prevention of Deficiency and Beyond</title><author>Ströhle, Alexander ; Richter, Margrit ; González-Gross, Marcela ; Neuhäuser-Berthold, Monika ; Wagner, Karl-Heinz ; Leschik-Bonnet, Eva ; Egert, Sarah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c177t-c2789c66caf6483a54f86fdbca7a2e0bedc9a7e3f5a35aa99605e097cb7f59e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological Availability</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Pregnancy</topic><topic>Reference Values</topic><topic>Vitamin B 12 - blood</topic><topic>Vitamin B 12 - pharmacokinetics</topic><topic>Vitamin B 12 Deficiency - blood</topic><topic>Vitamin B 12 Deficiency - prevention & control</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ströhle, Alexander</creatorcontrib><creatorcontrib>Richter, Margrit</creatorcontrib><creatorcontrib>González-Gross, Marcela</creatorcontrib><creatorcontrib>Neuhäuser-Berthold, Monika</creatorcontrib><creatorcontrib>Wagner, Karl-Heinz</creatorcontrib><creatorcontrib>Leschik-Bonnet, Eva</creatorcontrib><creatorcontrib>Egert, Sarah</creatorcontrib><creatorcontrib>German Nutrition Society (DGE)</creatorcontrib><creatorcontrib>for the German Nutrition Society (DGE)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Molecular nutrition & food research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ströhle, Alexander</au><au>Richter, Margrit</au><au>González-Gross, Marcela</au><au>Neuhäuser-Berthold, Monika</au><au>Wagner, Karl-Heinz</au><au>Leschik-Bonnet, Eva</au><au>Egert, Sarah</au><aucorp>German Nutrition Society (DGE)</aucorp><aucorp>for the German Nutrition Society (DGE)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Revised D-A-CH-Reference Values for the Intake of Vitamin B 12 : Prevention of Deficiency and Beyond</atitle><jtitle>Molecular nutrition & food research</jtitle><addtitle>Mol Nutr Food Res</addtitle><date>2019-03</date><risdate>2019</risdate><volume>63</volume><issue>6</issue><spage>e1801178</spage><pages>e1801178-</pages><issn>1613-4125</issn><eissn>1613-4133</eissn><abstract>The nutrition societies of Germany, Austria, and Switzerland are the joint editors of the "D-A-CH reference values for nutrient intake", which are revised regularly.
By reviewing vitamin-B
-related biomarker studies, the reference values for vitamin B
were revised in 2018. For adults, the estimated intake is based on the adequate serum concentrations of holotranscobalamin and methylmalonic acid. The estimated values for children and adolescents are extrapolated from the adult reference value by considering differences in body mass, an allometric exponent, and growth factors. For infants below 4 months of age, an estimated value is set based on the vitamin B
intake via breast milk. The reference values for pregnant and lactating women consider the requirements for the fetus and for loss via breast milk. The estimated values for vitamin B
intake for infants, children, and adolescents range from 0.5 to 4.0 µg d
. For adults, the estimated values are set at 4.0 µg d
, and for pregnant and lactating women, they are set at 4.5 and 5.5 µg d
, respectively.
Based on the data of several vitamin B
status biomarkers studies, the reference value for vitamin B
intake for adults is raised from 3.0 to 4.0 µg d
.</abstract><cop>Germany</cop><pmid>30657638</pmid><doi>10.1002/mnfr.201801178</doi></addata></record> |
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| ispartof | Molecular nutrition & food research, 2019-03, Vol.63 (6), p.e1801178 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Biological Availability Child Child, Preschool Female Homocysteine - blood Humans Infant Male Pregnancy Reference Values Vitamin B 12 - blood Vitamin B 12 - pharmacokinetics Vitamin B 12 Deficiency - blood Vitamin B 12 Deficiency - prevention & control Young Adult |
| title | The Revised D-A-CH-Reference Values for the Intake of Vitamin B 12 : Prevention of Deficiency and Beyond |
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