Phytoestrogenic activity of blackcurrant (Ribes nigrum) anthocyanins is mediated through estrogen receptor alpha

SCOPE: Blackcurrants (Ribes nigrum L., Grossulariaceae) contain high amounts of anthocyanin polyphenols, which have antioxidant and anti‐carcinogenic health benefits. This study analyzed the potential phytoestrogenic effects of blackcurrant extract (BCE) in breast cancer (MCF‐7) and human endometria...

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Veröffentlicht in:	Molecular nutrition & food research 2015-12, Vol.59 (12), p.2419-2431
Hauptverfasser:	Nanashima, Naoki, Horie, Kayo, Tomisawa, Toshiko, Chiba, Mitsuru, Nakano, Manabu, Fujita, Toshifumi, Maeda, Hayato, Kitajima, Maiko, Takamagi, Shizuka, Uchiyama, Daishi, Watanabe, Jun, Nakamura, Toshiya, Kato, Yoji
Format:	Artikel
Sprache:	eng
Schlagworte:	alkaline phosphatase Alkaline Phosphatase - metabolism Animals antagonists Anthocyanin anthocyanins Anthocyanins - chemistry Anthocyanins - metabolism Anthocyanins - pharmacology antioxidants Binding, Competitive black currants Blackcurrant breast neoplasms Cell Cycle - drug effects Cell Line, Tumor cell proliferation Endometrial Neoplasms - drug therapy Endometrial Neoplasms - metabolism Endometrial Neoplasms - pathology epithelial cells Estrogen Receptor beta - chemistry Estrogen Receptor beta - genetics Estrogen Receptor beta - metabolism estrogen receptors Estrogenic activity Female females flow cytometry Gene Expression Profiling gene expression regulation genes Humans MCF-7 Cells - drug effects microarray technology Molecular Docking Simulation mucins Phytoestrogen Phytoestrogens - pharmacology plant estrogens polyphenols rats Rats, Sprague-Dawley Ribes - chemistry Ribes nigrum transcription (genetics) uterine neoplasms Uterotrophic assay uterus
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