Isothiocyanates protect against oxidized LDL-induced endothelial dysfunction by upregulating Nrf2-dependent antioxidation and suppressing NFκB activation

Scope Oxidative stress plays a pivotal role in the pathophysiology of cardiovascular diseases. Oxidized low‐density lipoprotein (oxLDL) is a key contributor to atherogenesis through multiple mechanisms. In this study, we investigated the protection by three structurally related isothiocyanates, i.e....

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Veröffentlicht in:	Molecular nutrition & food research 2013-11, Vol.57 (11), p.1918-1930
Hauptverfasser:	Huang, Chin-Shiu, Lin, Ai-Hsuan, Liu, Cheng-Tzu, Tsai, Chia-Wen, Chang, Ing-Shr, Chen, Haw-Wen, Lii, Chong-Kuei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion molecules Antioxidant Response Elements - drug effects Antioxidants - pharmacology Biological and medical sciences Cell Adhesion - drug effects Dose-Response Relationship, Drug E-Selectin - genetics E-Selectin - metabolism Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Glutamate cysteine ligase Glutamate-Cysteine Ligase - genetics Glutamate-Cysteine Ligase - metabolism Heme oxygenase 1 Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - metabolism Isothiocyanates Isothiocyanates - pharmacology Leukocytes - drug effects Leukocytes - metabolism Lipoproteins, LDL - adverse effects NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism NF-kappa B - antagonists & inhibitors NF-kappa B - genetics NF-kappa B - metabolism Nuclear factor erythroid 2-related factor 2 (Nrf2) Nuclear factor-kappaB (NFκB) Oxidized LDL Reactive Oxygen Species - metabolism Up-Regulation Vascular Cell Adhesion Molecule-1 - genetics Vascular Cell Adhesion Molecule-1 - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems
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