Curcuminoids distinctly exhibit antioxidant activities and regulate expression of scavenger receptors and heme oxygenase-1

Scope Curcumin (CUR), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC) have been demonstrated as having antioxidant, anticarcinogenic, and hypocholesterolemic activities. We report the diverse antiatherogenic effects and mechanisms of curcuminoids. Methods and results We found that CUR was t...

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Veröffentlicht in:	Molecular nutrition & food research 2013-09, Vol.57 (9), p.1598-1610
Hauptverfasser:	Kou, Mei-Chun, Chiou, Shu-Yuan, Weng, Ching-Yi, Wang, Lisu, Ho, Chi-Tang, Wu, Ming-Jiuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - pharmacology Biomarkers - metabolism CD36 CD36 Antigens - genetics CD36 Antigens - metabolism Cell Differentiation - drug effects Cell Line, Tumor Copper - metabolism Curcumin Curcumin - analogs & derivatives Curcumin - pharmacology Diarylheptanoids Foam Cells - drug effects Foam Cells - metabolism GCLM Gene Expression Regulation Glutamate-Cysteine Ligase - genetics Glutamate-Cysteine Ligase - metabolism Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism HO-1 Humans Lipid Peroxidation - drug effects Lipoproteins, LDL - metabolism Monocytes - cytology Monocytes - drug effects Monocytes - metabolism oxLDL uptake Scavenger Receptors, Class A - metabolism Scavenger Receptors, Class E - genetics Scavenger Receptors, Class E - metabolism Tetradecanoylphorbol Acetate - analogs & derivatives Tetradecanoylphorbol Acetate - metabolism Thiobarbituric Acid Reactive Substances - metabolism Up-Regulation
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