Regulation of β-catenin and connexin-43 expression: Targets for sphingolipids in colon cancer prevention

Sphingolipid metabolites are generated throughout the intestinal tract after hydrolysis of orally administered complex sphingolipids and significantly suppress colon cancer in carcinogen-treated CF1 mice. In the present study, the mechanisms of tumor suppression by dietary sphingolipids were investi...

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Veröffentlicht in:	Molecular nutrition & food research 2009-03, Vol.53 (3), p.332-340
Hauptverfasser:	Simon, Kirk W, Roberts, Paul C, Vespremi, Michael J, Manchen, Steve, Schmelz, Eva M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Bcl-2 beta Catenin - analysis beta Catenin - genetics Blotting, Western Carcinogens Cell Division - genetics Colon cancer prevention Colonic Neoplasms - chemically induced Colonic Neoplasms - genetics Colonic Neoplasms - prevention & control Connexin 43 - analysis Connexin 43 - genetics Connexin-43 Diet Dimethylhydrazines Down-Regulation - drug effects Female Gene Expression Regulation - drug effects Genes, bcl-2 - genetics Immunohistochemistry Intestinal Mucosa - chemistry Mice Prognosis Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Sphingomyelin Sphingomyelins - administration & dosage β-catenin
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