Effect of intravenous injection of biperiden and clonazepam in dystonia
The acute effect of intravenous injections of biperiden and clonazepam was investigated in 14 patients with various forms of dystonia (segmental dystonia, 2; generalized dystonia, 6; and Meige's syndrome, 6). Eleven patients had primary dystonia, and 3 patients had a secondary form of dystonia....
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| Veröffentlicht in: | Movement disorders 1990, Vol.5 (1), p.27-31 |
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| container_title | Movement disorders |
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| creator | Povlsen, Uffe Juul Pakkenberg, Henning |
| description | The acute effect of intravenous injections of biperiden and clonazepam was investigated in 14 patients with various forms of dystonia (segmental dystonia, 2; generalized dystonia, 6; and Meige's syndrome, 6). Eleven patients had primary dystonia, and 3 patients had a secondary form of dystonia. Doses of 5 mg of biperiden reduced dystonia when evaluated by total scores, global scores, and subjective scores. Two patients had marked side effects in the form of dizziness. Doses of 1 mg of clonazepam significantly reduced total scores and subjective scores, but the reduction in global score was insignificant. No patient had marked side effects following injection with clonazepam. These results correspond with earlier investigations of the longterm effects of anticholinergics and benzodiazepines. It is concluded that in some cases, intravenous injections can be used as a test for evaluating both effects and side effects of antidystonic medication prior to the institution of oral treatment. Long‐term intravenous treatment might be considered in individual cases. |
| doi_str_mv | 10.1002/mds.870050107 |
| format | Article |
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Eleven patients had primary dystonia, and 3 patients had a secondary form of dystonia. Doses of 5 mg of biperiden reduced dystonia when evaluated by total scores, global scores, and subjective scores. Two patients had marked side effects in the form of dizziness. Doses of 1 mg of clonazepam significantly reduced total scores and subjective scores, but the reduction in global score was insignificant. No patient had marked side effects following injection with clonazepam. These results correspond with earlier investigations of the longterm effects of anticholinergics and benzodiazepines. It is concluded that in some cases, intravenous injections can be used as a test for evaluating both effects and side effects of antidystonic medication prior to the institution of oral treatment. Long‐term intravenous treatment might be considered in individual cases.</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.870050107</identifier><identifier>PMID: 2296254</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Biperiden ; Biperiden - administration & dosage ; Biperiden - adverse effects ; Biperiden - therapeutic use ; Clonazepam ; Clonazepam - administration & dosage ; Clonazepam - adverse effects ; Clonazepam - therapeutic use ; Dystonia ; Dystonia - drug therapy ; Female ; Humans ; Injections, Intravenous ; Male ; Medical sciences ; Middle Aged ; Neuropharmacology ; Pharmacology. Drug treatments ; Piperidines - therapeutic use</subject><ispartof>Movement disorders, 1990, Vol.5 (1), p.27-31</ispartof><rights>Copyright © 1990 Movement Disorder Society</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4037-7600fe8e9e31bdac01e6dfbfeb650fc11a7cc93b9ec8c19608fabf2730538a903</citedby><cites>FETCH-LOGICAL-c4037-7600fe8e9e31bdac01e6dfbfeb650fc11a7cc93b9ec8c19608fabf2730538a903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmds.870050107$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmds.870050107$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6700894$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2296254$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Povlsen, Uffe Juul</creatorcontrib><creatorcontrib>Pakkenberg, Henning</creatorcontrib><title>Effect of intravenous injection of biperiden and clonazepam in dystonia</title><title>Movement disorders</title><addtitle>Mov. Disord</addtitle><description>The acute effect of intravenous injections of biperiden and clonazepam was investigated in 14 patients with various forms of dystonia (segmental dystonia, 2; generalized dystonia, 6; and Meige's syndrome, 6). Eleven patients had primary dystonia, and 3 patients had a secondary form of dystonia. Doses of 5 mg of biperiden reduced dystonia when evaluated by total scores, global scores, and subjective scores. Two patients had marked side effects in the form of dizziness. Doses of 1 mg of clonazepam significantly reduced total scores and subjective scores, but the reduction in global score was insignificant. No patient had marked side effects following injection with clonazepam. These results correspond with earlier investigations of the longterm effects of anticholinergics and benzodiazepines. It is concluded that in some cases, intravenous injections can be used as a test for evaluating both effects and side effects of antidystonic medication prior to the institution of oral treatment. Long‐term intravenous treatment might be considered in individual cases.</description><subject>Adult</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>Biperiden</subject><subject>Biperiden - administration & dosage</subject><subject>Biperiden - adverse effects</subject><subject>Biperiden - therapeutic use</subject><subject>Clonazepam</subject><subject>Clonazepam - administration & dosage</subject><subject>Clonazepam - adverse effects</subject><subject>Clonazepam - therapeutic use</subject><subject>Dystonia</subject><subject>Dystonia - drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Piperidines - therapeutic use</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtLAzEQxoMotVaPHoU9eN062TSPPUqtreKDouIxZLMJpO6LZKvWv94tLYsnTzPM95tvhg-hcwxjDJBclXkYCw5AAQM_QENMCY5FQvkhGoIQNCZY0GN0EsIKAGOK2QANkiRlCZ0M0XxmrdFtVNvIVa1Xn6aq16HrV93U1dVWyFxjvMtNFakqj3RRV-rHNKrsqCjfhLaunDpFR1YVwZzt6wi93c5ep4v44Xl-N71-iPUECI85A7BGmNQQnOVKAzYst5k1GaNgNcaKa52SLDVaaJwyEFZlNuEEKBEqBTJC8c5X-zoEb6xsvCuV30gMcpuH7PKQfR4df7Hjm3VWmryn9wF0-uVeV0GrwnpVaRd6jHVGIt1ifId9ucJs_r8pH29e_j6wf9iF1nz3m8p_dOaEU_n-NJfLezZZwHQpgfwCituIOg</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Povlsen, Uffe Juul</creator><creator>Pakkenberg, Henning</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1990</creationdate><title>Effect of intravenous injection of biperiden and clonazepam in dystonia</title><author>Povlsen, Uffe Juul ; Pakkenberg, Henning</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4037-7600fe8e9e31bdac01e6dfbfeb650fc11a7cc93b9ec8c19608fabf2730538a903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Biological and medical sciences</topic><topic>Biperiden</topic><topic>Biperiden - administration & dosage</topic><topic>Biperiden - adverse effects</topic><topic>Biperiden - therapeutic use</topic><topic>Clonazepam</topic><topic>Clonazepam - administration & dosage</topic><topic>Clonazepam - adverse effects</topic><topic>Clonazepam - therapeutic use</topic><topic>Dystonia</topic><topic>Dystonia - drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Piperidines - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Povlsen, Uffe Juul</creatorcontrib><creatorcontrib>Pakkenberg, Henning</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Povlsen, Uffe Juul</au><au>Pakkenberg, Henning</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of intravenous injection of biperiden and clonazepam in dystonia</atitle><jtitle>Movement disorders</jtitle><addtitle>Mov. Disord</addtitle><date>1990</date><risdate>1990</risdate><volume>5</volume><issue>1</issue><spage>27</spage><epage>31</epage><pages>27-31</pages><issn>0885-3185</issn><eissn>1531-8257</eissn><abstract>The acute effect of intravenous injections of biperiden and clonazepam was investigated in 14 patients with various forms of dystonia (segmental dystonia, 2; generalized dystonia, 6; and Meige's syndrome, 6). Eleven patients had primary dystonia, and 3 patients had a secondary form of dystonia. Doses of 5 mg of biperiden reduced dystonia when evaluated by total scores, global scores, and subjective scores. Two patients had marked side effects in the form of dizziness. Doses of 1 mg of clonazepam significantly reduced total scores and subjective scores, but the reduction in global score was insignificant. No patient had marked side effects following injection with clonazepam. These results correspond with earlier investigations of the longterm effects of anticholinergics and benzodiazepines. It is concluded that in some cases, intravenous injections can be used as a test for evaluating both effects and side effects of antidystonic medication prior to the institution of oral treatment. Long‐term intravenous treatment might be considered in individual cases.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2296254</pmid><doi>10.1002/mds.870050107</doi><tpages>5</tpages></addata></record> |
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| ispartof | Movement disorders, 1990, Vol.5 (1), p.27-31 |
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| subjects | Adult Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Biperiden Biperiden - administration & dosage Biperiden - adverse effects Biperiden - therapeutic use Clonazepam Clonazepam - administration & dosage Clonazepam - adverse effects Clonazepam - therapeutic use Dystonia Dystonia - drug therapy Female Humans Injections, Intravenous Male Medical sciences Middle Aged Neuropharmacology Pharmacology. Drug treatments Piperidines - therapeutic use |
| title | Effect of intravenous injection of biperiden and clonazepam in dystonia |
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