Disease Progression in Patients with Parkin‐Related Parkinson's Disease in a Longitudinal Cohort

ABSTRACT Background There was a paucity of follow‐up studies in the disease progression of early‐onset PD patients with Parkin mutations (Parkin‐EOPD). Here we conducted a longitudinal study to investigate the progression of motor and cognitive features of Parkin‐EOPD patients. Methods Genetic analy...

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Veröffentlicht in:	Movement disorders 2021-02, Vol.36 (2), p.442-448
Hauptverfasser:	Sun, Yi‐Min, Yu, Hui‐Ling, Zhou, Xin‐Yue, Xiong, Wei‐Xi, Luo, Su‐Shan, Chen, Chen, Liu, Feng‐Tao, Zhao, Jue, Tang, Yi‐Lin, Liang, Xiao‐Niu, Yang, Yu‐Jie, Shen, Bo, Shen, Yan, Yu, Wen‐Bo, Ding, Zheng‐Tong, An, Yu, Wu, Jian‐Jun, Wang, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset Clinical Neurology Cognitive ability Disease Progression Genetic analysis Heterozygote Humans Information processing Life Sciences & Biomedicine Longitudinal Studies LRRK2 protein Movement disorders Mutation Mutation - genetics Neurodegenerative diseases Neurosciences & Neurology Parkin protein Parkinson Disease - genetics Parkinson's disease Parkinson's disease early onset cognition Parkin progression Science & Technology Ubiquitin-Protein Ligases - genetics
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