Polymorphism of XRCC1 and the frequency of mutation in codon 249 of the p 53 gene in hepatocellular carcinoma among guangxi population, China
In hepatocellular carcinoma (HCC), hotspot mutation in codon 249 of the p 53 gene has been associated with exposure to aflatoxin B1 (AFB1). While the polymorphism of DNA repair gene X‐ray repair cross‐complementary group 1 (XRCC1) Arg399Gln may be related with AFB1‐DNA adducts and gene mutations. Fi...
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| Veröffentlicht in: | Molecular carcinogenesis 2008-04, Vol.47 (4), p.295-300 |
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| creator | Long, Xi Dai Ma, Yun Huang, Hong Dong Yao, Jin Guang Qu, De Ying Lu, Yun Long |
| description | In hepatocellular carcinoma (HCC), hotspot mutation in codon 249 of the
p
53 gene has been associated with exposure to aflatoxin B1 (AFB1). While the polymorphism of DNA repair gene X‐ray repair cross‐complementary group 1 (XRCC1) Arg399Gln may be related with AFB1‐DNA adducts and gene mutations. Five hundred one HCCs were included in this study to investigate the role of the XRCC1 codon 399 polymorphism on hotspot mutation in codon 249 of the
p
53 gene. The genotypes of XRCC1 codon 399 and
p
53 codon 249 were examined by PCR‐RFLP. The HCC patients with XRCC1 genotypes with 399 Gln (namely: XRCC1‐AG/GG) exhibited a significantly higher frequency of the
p
53 hotspot mutations in codon 249 than those with the wild‐type homozygote of XRCC1 [namely: XRCC1‐AA, adjusted odds ratio (OR) = 6.77, 95% confidence interval (CI) = 4.34–10.57]. Compared with those individuals who did express XRCC1‐AA as reference (OR = 1), moreover, individuals featuring XRCC1‐AG/GG and AFB1‐DNA adducts did experience a significantly greater frequency of the hotspot mutation in codon 249 of the
p
53 gene (adjusted OR = 28.37, 95% CI = 13.19–61.02,
P
|
| doi_str_mv | 10.1002/mc.20384 |
| format | Article |
| fullrecord | <record><control><sourceid>crossref</sourceid><recordid>TN_cdi_crossref_primary_10_1002_mc_20384</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1002_mc_20384</sourcerecordid><originalsourceid>FETCH-LOGICAL-c724-4656be9d4ee2714f61473048ec997f38affcf739341e3ef1bdabbbc048bddc0c3</originalsourceid><addsrcrecordid>eNotkMFKxDAURYMoOI6Cn5ClCzsmTWbSLKXoKAwoMgt3JX19aStNUtMWnI_wn52qq3vhHO7iEnLN2Yozlt45WKVMZPKELDjTWZIqKU_JgmVaJ1xn6pxcDMMHY5yrNVuQ79fQHVyIfdMOjgZL39_ynFPjKzo2SG3Ezwk9HGbkptGMbfC09RRCdSyp1DOYzZ6uBa3R40wb7M0YALtu6kykYCK0PjhDjQu-pvVkfP3V0j70Rz5P3tK8ab25JGfWdANe_eeS7B8f9vlTsnvZPuf3uwRUKhO5WW9K1JVETBWXdsOlEkxmCForKzJjLVgltJAcBVpeVqYsSzgaZVUBA7EkN3-zEMMwRLRFH1tn4qHgrJhfLBwUvy-KHw0aZoA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Polymorphism of XRCC1 and the frequency of mutation in codon 249 of the p 53 gene in hepatocellular carcinoma among guangxi population, China</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Long, Xi Dai ; Ma, Yun ; Huang, Hong Dong ; Yao, Jin Guang ; Qu, De Ying ; Lu, Yun Long</creator><creatorcontrib>Long, Xi Dai ; Ma, Yun ; Huang, Hong Dong ; Yao, Jin Guang ; Qu, De Ying ; Lu, Yun Long</creatorcontrib><description>In hepatocellular carcinoma (HCC), hotspot mutation in codon 249 of the
p
53 gene has been associated with exposure to aflatoxin B1 (AFB1). While the polymorphism of DNA repair gene X‐ray repair cross‐complementary group 1 (XRCC1) Arg399Gln may be related with AFB1‐DNA adducts and gene mutations. Five hundred one HCCs were included in this study to investigate the role of the XRCC1 codon 399 polymorphism on hotspot mutation in codon 249 of the
p
53 gene. The genotypes of XRCC1 codon 399 and
p
53 codon 249 were examined by PCR‐RFLP. The HCC patients with XRCC1 genotypes with 399 Gln (namely: XRCC1‐AG/GG) exhibited a significantly higher frequency of the
p
53 hotspot mutations in codon 249 than those with the wild‐type homozygote of XRCC1 [namely: XRCC1‐AA, adjusted odds ratio (OR) = 6.77, 95% confidence interval (CI) = 4.34–10.57]. Compared with those individuals who did express XRCC1‐AA as reference (OR = 1), moreover, individuals featuring XRCC1‐AG/GG and AFB1‐DNA adducts did experience a significantly greater frequency of the hotspot mutation in codon 249 of the
p
53 gene (adjusted OR = 28.37, 95% CI = 13.19–61.02,
P
< 0.01). This study suggests that the XRCC1 Arg399Gln polymorphism and AFB1‐DNA adducts are associated with the increased frequency of the
p
53 mutations in codon 249. © 2007 Wiley‐Liss, Inc.</description><identifier>ISSN: 0899-1987</identifier><identifier>EISSN: 1098-2744</identifier><identifier>DOI: 10.1002/mc.20384</identifier><language>eng</language><ispartof>Molecular carcinogenesis, 2008-04, Vol.47 (4), p.295-300</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c724-4656be9d4ee2714f61473048ec997f38affcf739341e3ef1bdabbbc048bddc0c3</citedby><cites>FETCH-LOGICAL-c724-4656be9d4ee2714f61473048ec997f38affcf739341e3ef1bdabbbc048bddc0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Long, Xi Dai</creatorcontrib><creatorcontrib>Ma, Yun</creatorcontrib><creatorcontrib>Huang, Hong Dong</creatorcontrib><creatorcontrib>Yao, Jin Guang</creatorcontrib><creatorcontrib>Qu, De Ying</creatorcontrib><creatorcontrib>Lu, Yun Long</creatorcontrib><title>Polymorphism of XRCC1 and the frequency of mutation in codon 249 of the p 53 gene in hepatocellular carcinoma among guangxi population, China</title><title>Molecular carcinogenesis</title><description>In hepatocellular carcinoma (HCC), hotspot mutation in codon 249 of the
p
53 gene has been associated with exposure to aflatoxin B1 (AFB1). While the polymorphism of DNA repair gene X‐ray repair cross‐complementary group 1 (XRCC1) Arg399Gln may be related with AFB1‐DNA adducts and gene mutations. Five hundred one HCCs were included in this study to investigate the role of the XRCC1 codon 399 polymorphism on hotspot mutation in codon 249 of the
p
53 gene. The genotypes of XRCC1 codon 399 and
p
53 codon 249 were examined by PCR‐RFLP. The HCC patients with XRCC1 genotypes with 399 Gln (namely: XRCC1‐AG/GG) exhibited a significantly higher frequency of the
p
53 hotspot mutations in codon 249 than those with the wild‐type homozygote of XRCC1 [namely: XRCC1‐AA, adjusted odds ratio (OR) = 6.77, 95% confidence interval (CI) = 4.34–10.57]. Compared with those individuals who did express XRCC1‐AA as reference (OR = 1), moreover, individuals featuring XRCC1‐AG/GG and AFB1‐DNA adducts did experience a significantly greater frequency of the hotspot mutation in codon 249 of the
p
53 gene (adjusted OR = 28.37, 95% CI = 13.19–61.02,
P
< 0.01). This study suggests that the XRCC1 Arg399Gln polymorphism and AFB1‐DNA adducts are associated with the increased frequency of the
p
53 mutations in codon 249. © 2007 Wiley‐Liss, Inc.</description><issn>0899-1987</issn><issn>1098-2744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNotkMFKxDAURYMoOI6Cn5ClCzsmTWbSLKXoKAwoMgt3JX19aStNUtMWnI_wn52qq3vhHO7iEnLN2Yozlt45WKVMZPKELDjTWZIqKU_JgmVaJ1xn6pxcDMMHY5yrNVuQ79fQHVyIfdMOjgZL39_ynFPjKzo2SG3Ezwk9HGbkptGMbfC09RRCdSyp1DOYzZ6uBa3R40wb7M0YALtu6kykYCK0PjhDjQu-pvVkfP3V0j70Rz5P3tK8ab25JGfWdANe_eeS7B8f9vlTsnvZPuf3uwRUKhO5WW9K1JVETBWXdsOlEkxmCForKzJjLVgltJAcBVpeVqYsSzgaZVUBA7EkN3-zEMMwRLRFH1tn4qHgrJhfLBwUvy-KHw0aZoA</recordid><startdate>200804</startdate><enddate>200804</enddate><creator>Long, Xi Dai</creator><creator>Ma, Yun</creator><creator>Huang, Hong Dong</creator><creator>Yao, Jin Guang</creator><creator>Qu, De Ying</creator><creator>Lu, Yun Long</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200804</creationdate><title>Polymorphism of XRCC1 and the frequency of mutation in codon 249 of the p 53 gene in hepatocellular carcinoma among guangxi population, China</title><author>Long, Xi Dai ; Ma, Yun ; Huang, Hong Dong ; Yao, Jin Guang ; Qu, De Ying ; Lu, Yun Long</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c724-4656be9d4ee2714f61473048ec997f38affcf739341e3ef1bdabbbc048bddc0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Long, Xi Dai</creatorcontrib><creatorcontrib>Ma, Yun</creatorcontrib><creatorcontrib>Huang, Hong Dong</creatorcontrib><creatorcontrib>Yao, Jin Guang</creatorcontrib><creatorcontrib>Qu, De Ying</creatorcontrib><creatorcontrib>Lu, Yun Long</creatorcontrib><collection>CrossRef</collection><jtitle>Molecular carcinogenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Long, Xi Dai</au><au>Ma, Yun</au><au>Huang, Hong Dong</au><au>Yao, Jin Guang</au><au>Qu, De Ying</au><au>Lu, Yun Long</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphism of XRCC1 and the frequency of mutation in codon 249 of the p 53 gene in hepatocellular carcinoma among guangxi population, China</atitle><jtitle>Molecular carcinogenesis</jtitle><date>2008-04</date><risdate>2008</risdate><volume>47</volume><issue>4</issue><spage>295</spage><epage>300</epage><pages>295-300</pages><issn>0899-1987</issn><eissn>1098-2744</eissn><abstract>In hepatocellular carcinoma (HCC), hotspot mutation in codon 249 of the
p
53 gene has been associated with exposure to aflatoxin B1 (AFB1). While the polymorphism of DNA repair gene X‐ray repair cross‐complementary group 1 (XRCC1) Arg399Gln may be related with AFB1‐DNA adducts and gene mutations. Five hundred one HCCs were included in this study to investigate the role of the XRCC1 codon 399 polymorphism on hotspot mutation in codon 249 of the
p
53 gene. The genotypes of XRCC1 codon 399 and
p
53 codon 249 were examined by PCR‐RFLP. The HCC patients with XRCC1 genotypes with 399 Gln (namely: XRCC1‐AG/GG) exhibited a significantly higher frequency of the
p
53 hotspot mutations in codon 249 than those with the wild‐type homozygote of XRCC1 [namely: XRCC1‐AA, adjusted odds ratio (OR) = 6.77, 95% confidence interval (CI) = 4.34–10.57]. Compared with those individuals who did express XRCC1‐AA as reference (OR = 1), moreover, individuals featuring XRCC1‐AG/GG and AFB1‐DNA adducts did experience a significantly greater frequency of the hotspot mutation in codon 249 of the
p
53 gene (adjusted OR = 28.37, 95% CI = 13.19–61.02,
P
< 0.01). This study suggests that the XRCC1 Arg399Gln polymorphism and AFB1‐DNA adducts are associated with the increased frequency of the
p
53 mutations in codon 249. © 2007 Wiley‐Liss, Inc.</abstract><doi>10.1002/mc.20384</doi><tpages>6</tpages></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| title | Polymorphism of XRCC1 and the frequency of mutation in codon 249 of the p 53 gene in hepatocellular carcinoma among guangxi population, China |
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