Facile synthesis of new amine high-loaded poly(meth)acrylamide-based resins for solid phase peptide

Two methods for the ready preparation of some protected primary amine‐functionalized (meth)acrylamide derivatives from amino halides or amino alcohols are described. The (meth)acryloyl moiety is introduced either in the last step from unsymmetrically N,N′‐disubstituted diamines or, more simply, in the first step, but that demands a special work‐up of the reaction mixture in order to prevent polymerization. Both methods are complementary. Reverse phase suspension polymerization of the title compounds with N‐acryloylpyrrolidine and N,N′‐ethylenebis(acrylamide) directly affords new beaded, high‐loaded aminefunctionalized resins for solid phase peptide synthesis.