Initial results of endothelial cell seeding following argon laser carotid endarterectomy
This study evaluates the initial results of endothelial cell (EC) seeding following argon laser carotid endarterectomy. Venous endothelial cells were harvested from 12 dogs and cultured. A laser endarterectomy was performed on both carotids of each dog. One side was seeded with endothelial cells. Si...
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| Veröffentlicht in: | Lasers in surgery and medicine 1992, Vol.12 (6), p.569-575 |
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| creator | Sawchuk, Alan P. Herring, Malcolm B. Dalsing, Michael C. |
| description | This study evaluates the initial results of endothelial cell (EC) seeding following argon laser carotid endarterectomy. Venous endothelial cells were harvested from 12 dogs and cultured. A laser endarterectomy was performed on both carotids of each dog. One side was seeded with endothelial cells. Six dogs had both carotids harvested 1 hour after restoring blood flow. The others were harvested in 24 hours. The percentage of lumen covered with EC was evaluated by scanning electron microscopy. At 1 hour, the seeded arteries demonstrated 35 ± 3 percent EC coverage, whereas the unseeded arteries had no EC coverage (P = 0.0002). At 24 hours, the seeded arteries had 58 ± 15 percent EC coverage, whereas the unseeded arteries had no coverage (P = 0.01). Significant gross thrombus developed only in unseeded arteries (P = 0.047), two of which were occluded at 24 hours. EC seeding is beneficial following argon laser carotid endarterectomy resulting in improved patency and less surface thrombogenicty. © 1992 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/lsm.1900120602 |
| format | Article |
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Venous endothelial cells were harvested from 12 dogs and cultured. A laser endarterectomy was performed on both carotids of each dog. One side was seeded with endothelial cells. Six dogs had both carotids harvested 1 hour after restoring blood flow. The others were harvested in 24 hours. The percentage of lumen covered with EC was evaluated by scanning electron microscopy. At 1 hour, the seeded arteries demonstrated 35 ± 3 percent EC coverage, whereas the unseeded arteries had no EC coverage (P = 0.0002). At 24 hours, the seeded arteries had 58 ± 15 percent EC coverage, whereas the unseeded arteries had no coverage (P = 0.01). Significant gross thrombus developed only in unseeded arteries (P = 0.047), two of which were occluded at 24 hours. EC seeding is beneficial following argon laser carotid endarterectomy resulting in improved patency and less surface thrombogenicty. © 1992 Wiley‐Liss, Inc.</description><identifier>ISSN: 0196-8092</identifier><identifier>EISSN: 1096-9101</identifier><identifier>DOI: 10.1002/lsm.1900120602</identifier><identifier>PMID: 1453857</identifier><identifier>CODEN: LSMEDI</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Animals ; argon laser ; Biological and medical sciences ; Carotid Arteries - surgery ; Carotid Arteries - ultrastructure ; Carotid Artery Diseases - prevention & control ; carotid endarterectomy ; Cells, Cultured ; Dogs ; Endarterectomy, Carotid ; endothelial cell seeding ; Endothelium, Vascular - cytology ; Endothelium, Vascular - ultrastructure ; Laser Therapy ; Medical sciences ; Microscopy, Electron, Scanning ; Surface Properties ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Thrombosis - prevention & control ; Vascular Patency ; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><ispartof>Lasers in surgery and medicine, 1992, Vol.12 (6), p.569-575</ispartof><rights>Copyright © 1992 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4072-7c6347ab66bbaf14dd1c417c84b52ce1f88c6442163d27ba97ba4df3fc6c6b9d3</citedby><cites>FETCH-LOGICAL-c4072-7c6347ab66bbaf14dd1c417c84b52ce1f88c6442163d27ba97ba4df3fc6c6b9d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flsm.1900120602$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flsm.1900120602$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,1417,4024,4050,4051,23930,23931,25140,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4448947$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1453857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sawchuk, Alan P.</creatorcontrib><creatorcontrib>Herring, Malcolm B.</creatorcontrib><creatorcontrib>Dalsing, Michael C.</creatorcontrib><title>Initial results of endothelial cell seeding following argon laser carotid endarterectomy</title><title>Lasers in surgery and medicine</title><addtitle>Lasers Surg. Med</addtitle><description>This study evaluates the initial results of endothelial cell (EC) seeding following argon laser carotid endarterectomy. Venous endothelial cells were harvested from 12 dogs and cultured. A laser endarterectomy was performed on both carotids of each dog. One side was seeded with endothelial cells. Six dogs had both carotids harvested 1 hour after restoring blood flow. The others were harvested in 24 hours. The percentage of lumen covered with EC was evaluated by scanning electron microscopy. At 1 hour, the seeded arteries demonstrated 35 ± 3 percent EC coverage, whereas the unseeded arteries had no EC coverage (P = 0.0002). At 24 hours, the seeded arteries had 58 ± 15 percent EC coverage, whereas the unseeded arteries had no coverage (P = 0.01). Significant gross thrombus developed only in unseeded arteries (P = 0.047), two of which were occluded at 24 hours. EC seeding is beneficial following argon laser carotid endarterectomy resulting in improved patency and less surface thrombogenicty. © 1992 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>argon laser</subject><subject>Biological and medical sciences</subject><subject>Carotid Arteries - surgery</subject><subject>Carotid Arteries - ultrastructure</subject><subject>Carotid Artery Diseases - prevention & control</subject><subject>carotid endarterectomy</subject><subject>Cells, Cultured</subject><subject>Dogs</subject><subject>Endarterectomy, Carotid</subject><subject>endothelial cell seeding</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - ultrastructure</subject><subject>Laser Therapy</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Surface Properties</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Thrombosis - prevention & control</subject><subject>Vascular Patency</subject><subject>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><issn>0196-8092</issn><issn>1096-9101</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtv1DAQxi0EKkvLlRtSDohblvEjdnxEVVuKlkdbENwsx49icOJiZ9Xuf99EWbXixGE0o5nfNzP6EHqFYY0ByLtY-jWWAJgAB_IErTBIXksM-ClaAZ7qFiR5jl6U8hsAKAFxgA4wa2jbiBX6eT6EMehYZVe2cSxV8pUbbBp_uTi3jYuxKs7ZMFxXPsWYbudK5-s0VFEXlyujcxqDnWU6jy47M6Z-d4SeeR2Le7nPh-j76cm34w_15svZ-fH7TW0YCFILwykTuuO867THzFpsGBamZV1DjMO-bQ1njGBOLRGdllMw66k33PBOWnqI3i57b3L6u3VlVH0o89d6cGlblKC05dDICVwvoMmplOy8usmh13mnMKjZSjVZqR6tnASv95u3Xe_sI754N83f7Oe6GB191oMJ5QFjjLWSzZhcsNsQ3e4_R9Xm6tM_L9SLNpTR3T1odf6juKCiUT8-nyn5keHLi6-tOqX3DASdMw</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Sawchuk, Alan P.</creator><creator>Herring, Malcolm B.</creator><creator>Dalsing, Michael C.</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Initial results of endothelial cell seeding following argon laser carotid endarterectomy</title><author>Sawchuk, Alan P. ; Herring, Malcolm B. ; Dalsing, Michael C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4072-7c6347ab66bbaf14dd1c417c84b52ce1f88c6442163d27ba97ba4df3fc6c6b9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>argon laser</topic><topic>Biological and medical sciences</topic><topic>Carotid Arteries - surgery</topic><topic>Carotid Arteries - ultrastructure</topic><topic>Carotid Artery Diseases - prevention & control</topic><topic>carotid endarterectomy</topic><topic>Cells, Cultured</topic><topic>Dogs</topic><topic>Endarterectomy, Carotid</topic><topic>endothelial cell seeding</topic><topic>Endothelium, Vascular - cytology</topic><topic>Endothelium, Vascular - ultrastructure</topic><topic>Laser Therapy</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>Surface Properties</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Thrombosis - prevention & control</topic><topic>Vascular Patency</topic><topic>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sawchuk, Alan P.</creatorcontrib><creatorcontrib>Herring, Malcolm B.</creatorcontrib><creatorcontrib>Dalsing, Michael C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lasers in surgery and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sawchuk, Alan P.</au><au>Herring, Malcolm B.</au><au>Dalsing, Michael C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Initial results of endothelial cell seeding following argon laser carotid endarterectomy</atitle><jtitle>Lasers in surgery and medicine</jtitle><addtitle>Lasers Surg. Med</addtitle><date>1992</date><risdate>1992</risdate><volume>12</volume><issue>6</issue><spage>569</spage><epage>575</epage><pages>569-575</pages><issn>0196-8092</issn><eissn>1096-9101</eissn><coden>LSMEDI</coden><abstract>This study evaluates the initial results of endothelial cell (EC) seeding following argon laser carotid endarterectomy. Venous endothelial cells were harvested from 12 dogs and cultured. A laser endarterectomy was performed on both carotids of each dog. One side was seeded with endothelial cells. Six dogs had both carotids harvested 1 hour after restoring blood flow. The others were harvested in 24 hours. The percentage of lumen covered with EC was evaluated by scanning electron microscopy. At 1 hour, the seeded arteries demonstrated 35 ± 3 percent EC coverage, whereas the unseeded arteries had no EC coverage (P = 0.0002). At 24 hours, the seeded arteries had 58 ± 15 percent EC coverage, whereas the unseeded arteries had no coverage (P = 0.01). Significant gross thrombus developed only in unseeded arteries (P = 0.047), two of which were occluded at 24 hours. EC seeding is beneficial following argon laser carotid endarterectomy resulting in improved patency and less surface thrombogenicty. © 1992 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>1453857</pmid><doi>10.1002/lsm.1900120602</doi><tpages>7</tpages></addata></record> |
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| ispartof | Lasers in surgery and medicine, 1992, Vol.12 (6), p.569-575 |
| issn | 0196-8092 1096-9101 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Animals argon laser Biological and medical sciences Carotid Arteries - surgery Carotid Arteries - ultrastructure Carotid Artery Diseases - prevention & control carotid endarterectomy Cells, Cultured Dogs Endarterectomy, Carotid endothelial cell seeding Endothelium, Vascular - cytology Endothelium, Vascular - ultrastructure Laser Therapy Medical sciences Microscopy, Electron, Scanning Surface Properties Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Thrombosis - prevention & control Vascular Patency Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels |
| title | Initial results of endothelial cell seeding following argon laser carotid endarterectomy |
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