A new 111 in‐bleomycin complex for combined radiotherapy and chemotherapy
Six days after tumor transplantation three daily intraperitoneal doses of 0.9% NaCl, bleomycin (BLM), or a new 111 In‐bleomycin complex (BLMC, 15 μCi/g body weight) were administered to glioma‐bearing mice. After therapy, tumors in mice treated with 111 In‐BLMC were smaller than those treated with B...
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| Veröffentlicht in: | Journal of surgical oncology 1985-06, Vol.29 (2), p.91-98 |
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| container_title | Journal of surgical oncology |
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| creator | Hou, De‐Yan Hoch, Hans Johnston, Gerald S. Tsou, K. C. Jones, Alfred E. Farkas, Raymond J. Miller, Elizabeth E. Larson, Steven M. |
| description | Six days after tumor transplantation three daily intraperitoneal doses of 0.9% NaCl, bleomycin (BLM), or a new
111
In‐bleomycin complex (BLMC, 15 μCi/g body weight) were administered to glioma‐bearing mice. After therapy, tumors in mice treated with
111
In‐BLMC were smaller than those treated with BLM. Sixteen days after the first injection tumor size for
111
In‐BLMC‐treated mice was 560 (240–1,030) mm
3
, 1,980 (1,400–3,290) mm
3
for BLM (P < 0.025), and 4,830 (2,580–9, 180) mm
3
for NaCl (0.1 < P < 0.2).
Thirteen days after tumor transplantation glioma‐bearing mice received single intratumor injection of 0.9% NaCl, BLM, or
111
In‐BLMC (1.5 mCi, carried by 0.5 mg BLM/g tumor weight). The average tumor size for
111
In‐BLMC was smaller than that for BLM by a factor of 2.5–3.7. Host weights for these two groups were similar, and morphologic abnormalities were not found in kidney or liver. |
| doi_str_mv | 10.1002/jso.2930290206 |
| format | Article |
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111
In‐bleomycin complex (BLMC, 15 μCi/g body weight) were administered to glioma‐bearing mice. After therapy, tumors in mice treated with
111
In‐BLMC were smaller than those treated with BLM. Sixteen days after the first injection tumor size for
111
In‐BLMC‐treated mice was 560 (240–1,030) mm
3
, 1,980 (1,400–3,290) mm
3
for BLM (P < 0.025), and 4,830 (2,580–9, 180) mm
3
for NaCl (0.1 < P < 0.2).
Thirteen days after tumor transplantation glioma‐bearing mice received single intratumor injection of 0.9% NaCl, BLM, or
111
In‐BLMC (1.5 mCi, carried by 0.5 mg BLM/g tumor weight). The average tumor size for
111
In‐BLMC was smaller than that for BLM by a factor of 2.5–3.7. Host weights for these two groups were similar, and morphologic abnormalities were not found in kidney or liver.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.2930290206</identifier><language>eng</language><ispartof>Journal of surgical oncology, 1985-06, Vol.29 (2), p.91-98</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c169t-4897cdd4c73a8ced68faa93bdc5306d140517aac76bea3a6ee780234dfdc94c43</citedby><cites>FETCH-LOGICAL-c169t-4897cdd4c73a8ced68faa93bdc5306d140517aac76bea3a6ee780234dfdc94c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Hou, De‐Yan</creatorcontrib><creatorcontrib>Hoch, Hans</creatorcontrib><creatorcontrib>Johnston, Gerald S.</creatorcontrib><creatorcontrib>Tsou, K. C.</creatorcontrib><creatorcontrib>Jones, Alfred E.</creatorcontrib><creatorcontrib>Farkas, Raymond J.</creatorcontrib><creatorcontrib>Miller, Elizabeth E.</creatorcontrib><creatorcontrib>Larson, Steven M.</creatorcontrib><title>A new 111 in‐bleomycin complex for combined radiotherapy and chemotherapy</title><title>Journal of surgical oncology</title><description>Six days after tumor transplantation three daily intraperitoneal doses of 0.9% NaCl, bleomycin (BLM), or a new
111
In‐bleomycin complex (BLMC, 15 μCi/g body weight) were administered to glioma‐bearing mice. After therapy, tumors in mice treated with
111
In‐BLMC were smaller than those treated with BLM. Sixteen days after the first injection tumor size for
111
In‐BLMC‐treated mice was 560 (240–1,030) mm
3
, 1,980 (1,400–3,290) mm
3
for BLM (P < 0.025), and 4,830 (2,580–9, 180) mm
3
for NaCl (0.1 < P < 0.2).
Thirteen days after tumor transplantation glioma‐bearing mice received single intratumor injection of 0.9% NaCl, BLM, or
111
In‐BLMC (1.5 mCi, carried by 0.5 mg BLM/g tumor weight). The average tumor size for
111
In‐BLMC was smaller than that for BLM by a factor of 2.5–3.7. Host weights for these two groups were similar, and morphologic abnormalities were not found in kidney or liver.</description><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><recordid>eNpFkM1KxDAUhYMoWEe3rvMCrTc_kzTLYfAPB9zoutwmt0yHtinpgHbnI_iMPokzqLg6h8PHWXyMXQsoBIC82U2xkE6BdCDBnLBMgDO5A1eesuwAyFxbB-fsYpp2AOCc0Rl7WvGB3rgQgrfD18dn3VHsZ98O3Md-7OidNzEde90OFHjC0Mb9lhKOM8chcL-l_m-4ZGcNdhNd_eaCvd7dvqwf8s3z_eN6tcm9MG6f69JZH4L2VmHpKZiyQXSqDn6pwAShYSksoremJlRoiGwJUunQBO-012rBip9fn-I0JWqqMbU9prkSUB1VVAcV1b8K9Q0I91Pa</recordid><startdate>198506</startdate><enddate>198506</enddate><creator>Hou, De‐Yan</creator><creator>Hoch, Hans</creator><creator>Johnston, Gerald S.</creator><creator>Tsou, K. C.</creator><creator>Jones, Alfred E.</creator><creator>Farkas, Raymond J.</creator><creator>Miller, Elizabeth E.</creator><creator>Larson, Steven M.</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198506</creationdate><title>A new 111 in‐bleomycin complex for combined radiotherapy and chemotherapy</title><author>Hou, De‐Yan ; Hoch, Hans ; Johnston, Gerald S. ; Tsou, K. C. ; Jones, Alfred E. ; Farkas, Raymond J. ; Miller, Elizabeth E. ; Larson, Steven M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c169t-4897cdd4c73a8ced68faa93bdc5306d140517aac76bea3a6ee780234dfdc94c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hou, De‐Yan</creatorcontrib><creatorcontrib>Hoch, Hans</creatorcontrib><creatorcontrib>Johnston, Gerald S.</creatorcontrib><creatorcontrib>Tsou, K. C.</creatorcontrib><creatorcontrib>Jones, Alfred E.</creatorcontrib><creatorcontrib>Farkas, Raymond J.</creatorcontrib><creatorcontrib>Miller, Elizabeth E.</creatorcontrib><creatorcontrib>Larson, Steven M.</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hou, De‐Yan</au><au>Hoch, Hans</au><au>Johnston, Gerald S.</au><au>Tsou, K. C.</au><au>Jones, Alfred E.</au><au>Farkas, Raymond J.</au><au>Miller, Elizabeth E.</au><au>Larson, Steven M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new 111 in‐bleomycin complex for combined radiotherapy and chemotherapy</atitle><jtitle>Journal of surgical oncology</jtitle><date>1985-06</date><risdate>1985</risdate><volume>29</volume><issue>2</issue><spage>91</spage><epage>98</epage><pages>91-98</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Six days after tumor transplantation three daily intraperitoneal doses of 0.9% NaCl, bleomycin (BLM), or a new
111
In‐bleomycin complex (BLMC, 15 μCi/g body weight) were administered to glioma‐bearing mice. After therapy, tumors in mice treated with
111
In‐BLMC were smaller than those treated with BLM. Sixteen days after the first injection tumor size for
111
In‐BLMC‐treated mice was 560 (240–1,030) mm
3
, 1,980 (1,400–3,290) mm
3
for BLM (P < 0.025), and 4,830 (2,580–9, 180) mm
3
for NaCl (0.1 < P < 0.2).
Thirteen days after tumor transplantation glioma‐bearing mice received single intratumor injection of 0.9% NaCl, BLM, or
111
In‐BLMC (1.5 mCi, carried by 0.5 mg BLM/g tumor weight). The average tumor size for
111
In‐BLMC was smaller than that for BLM by a factor of 2.5–3.7. Host weights for these two groups were similar, and morphologic abnormalities were not found in kidney or liver.</abstract><doi>10.1002/jso.2930290206</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of surgical oncology, 1985-06, Vol.29 (2), p.91-98 |
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| language | eng |
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| source | Access via Wiley Online Library |
| title | A new 111 in‐bleomycin complex for combined radiotherapy and chemotherapy |
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