A new 111 in‐bleomycin complex for tumor imaging: Preparation, stability, and distribution in glioma‐bearing mice
A new 111 In‐bleomycin complex ( 111 In‐BLMC) is here reported. Its radiochemical purity was 99% by thin‐layer chromatography (TLC) (Rf 0.65) and in 5% agarose gel electrophoresis in 0.02 M NaHCO 3 it migrated toward the anode. Autoradiographs of TLC and gel electrophoresis plates showed no change o...
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| Veröffentlicht in: | Journal of surgical oncology 1984-03, Vol.25 (3), p.168-175 |
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| container_title | Journal of surgical oncology |
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| creator | Hou, De‐Yan Hoch, Hans Johnston, Gerald S. Tsou, K. C. Jones, Alfred E. Farkas, Raymond J. Miller, Elizabeth E. |
| description | A new
111
In‐bleomycin complex (
111
In‐BLMC) is here reported. Its radiochemical purity was 99% by thin‐layer chromatography (TLC) (Rf 0.65) and in 5% agarose gel electrophoresis in 0.02 M NaHCO
3
it migrated toward the anode. Autoradiographs of TLC and gel electrophoresis plates showed no change on storage for 3 weeks. Urine and plasma from untreated or glioma‐bearing mice after injection of
111
In‐BLMC were analyzed by TLC and gel electrophoresis. Results indicated stability in vivo, nonbinding to transferrin, affinity to viable tumor, and excretion faster than
111
In‐BLM‐B
2
,
111
In‐BLM, or
57
Co‐BLM. Tissue distributions 24 hr after injection of radiopharmaceutical showed activity ratios of tumor to blood, muscle, and brain of 13.1, 12.4, and 81.6, respectively, which were significantly higher than those for previously prepared
111
In‐BLM‐B
2
or
111
In‐BLM (except for brain, 0.05 < P < 0.1). The new
111
In‐BLM complex may be useful in clinical imaging and for combining radionuclide radiotherapy and chemotherapy. |
| doi_str_mv | 10.1002/jso.2930250307 |
| format | Article |
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111
In‐bleomycin complex (
111
In‐BLMC) is here reported. Its radiochemical purity was 99% by thin‐layer chromatography (TLC) (Rf 0.65) and in 5% agarose gel electrophoresis in 0.02 M NaHCO
3
it migrated toward the anode. Autoradiographs of TLC and gel electrophoresis plates showed no change on storage for 3 weeks. Urine and plasma from untreated or glioma‐bearing mice after injection of
111
In‐BLMC were analyzed by TLC and gel electrophoresis. Results indicated stability in vivo, nonbinding to transferrin, affinity to viable tumor, and excretion faster than
111
In‐BLM‐B
2
,
111
In‐BLM, or
57
Co‐BLM. Tissue distributions 24 hr after injection of radiopharmaceutical showed activity ratios of tumor to blood, muscle, and brain of 13.1, 12.4, and 81.6, respectively, which were significantly higher than those for previously prepared
111
In‐BLM‐B
2
or
111
In‐BLM (except for brain, 0.05 < P < 0.1). The new
111
In‐BLM complex may be useful in clinical imaging and for combining radionuclide radiotherapy and chemotherapy.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.2930250307</identifier><language>eng</language><ispartof>Journal of surgical oncology, 1984-03, Vol.25 (3), p.168-175</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c847-c5fb97e35b80b0a508b64a271010483aae6aa622eae414eced27fe3bf2712c0d3</citedby><cites>FETCH-LOGICAL-c847-c5fb97e35b80b0a508b64a271010483aae6aa622eae414eced27fe3bf2712c0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Hou, De‐Yan</creatorcontrib><creatorcontrib>Hoch, Hans</creatorcontrib><creatorcontrib>Johnston, Gerald S.</creatorcontrib><creatorcontrib>Tsou, K. C.</creatorcontrib><creatorcontrib>Jones, Alfred E.</creatorcontrib><creatorcontrib>Farkas, Raymond J.</creatorcontrib><creatorcontrib>Miller, Elizabeth E.</creatorcontrib><title>A new 111 in‐bleomycin complex for tumor imaging: Preparation, stability, and distribution in glioma‐bearing mice</title><title>Journal of surgical oncology</title><description>A new
111
In‐bleomycin complex (
111
In‐BLMC) is here reported. Its radiochemical purity was 99% by thin‐layer chromatography (TLC) (Rf 0.65) and in 5% agarose gel electrophoresis in 0.02 M NaHCO
3
it migrated toward the anode. Autoradiographs of TLC and gel electrophoresis plates showed no change on storage for 3 weeks. Urine and plasma from untreated or glioma‐bearing mice after injection of
111
In‐BLMC were analyzed by TLC and gel electrophoresis. Results indicated stability in vivo, nonbinding to transferrin, affinity to viable tumor, and excretion faster than
111
In‐BLM‐B
2
,
111
In‐BLM, or
57
Co‐BLM. Tissue distributions 24 hr after injection of radiopharmaceutical showed activity ratios of tumor to blood, muscle, and brain of 13.1, 12.4, and 81.6, respectively, which were significantly higher than those for previously prepared
111
In‐BLM‐B
2
or
111
In‐BLM (except for brain, 0.05 < P < 0.1). The new
111
In‐BLM complex may be useful in clinical imaging and for combining radionuclide radiotherapy and chemotherapy.</description><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><recordid>eNpFkMtOwzAQRS0EEqWwZe0PaMrYeZpdVfGSKsGi-2jsTCpXSVzZqaA7PoFv5EtwBBKbmcXce6Q5jN0KWAoAebcPbilVCjKHFMozNhOgikSBqs7ZLAZkkpUKLtlVCHsAUKrIZuy44gO9cyEEt8P355fuyPUnYwduXH_o6IO3zvPx2Mdpe9zZYXfP3zwd0ONo3bDgYURtOzueFhyHhjc2jN7q43SMSL7rrOtxIhP62Oa9NXTNLlrsAt387TnbPj5s18_J5vXpZb3aJKbKysTkrVYlpbmuQAPmUOkiQ1kKEJBVKSIViIWUhJSJjAw1smwp1W2MSANNOmfLX6zxLgRPbX3w8Ql_qgXUk7M6Oqv_naU_DuljJg</recordid><startdate>198403</startdate><enddate>198403</enddate><creator>Hou, De‐Yan</creator><creator>Hoch, Hans</creator><creator>Johnston, Gerald S.</creator><creator>Tsou, K. C.</creator><creator>Jones, Alfred E.</creator><creator>Farkas, Raymond J.</creator><creator>Miller, Elizabeth E.</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198403</creationdate><title>A new 111 in‐bleomycin complex for tumor imaging: Preparation, stability, and distribution in glioma‐bearing mice</title><author>Hou, De‐Yan ; Hoch, Hans ; Johnston, Gerald S. ; Tsou, K. C. ; Jones, Alfred E. ; Farkas, Raymond J. ; Miller, Elizabeth E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c847-c5fb97e35b80b0a508b64a271010483aae6aa622eae414eced27fe3bf2712c0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hou, De‐Yan</creatorcontrib><creatorcontrib>Hoch, Hans</creatorcontrib><creatorcontrib>Johnston, Gerald S.</creatorcontrib><creatorcontrib>Tsou, K. C.</creatorcontrib><creatorcontrib>Jones, Alfred E.</creatorcontrib><creatorcontrib>Farkas, Raymond J.</creatorcontrib><creatorcontrib>Miller, Elizabeth E.</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hou, De‐Yan</au><au>Hoch, Hans</au><au>Johnston, Gerald S.</au><au>Tsou, K. C.</au><au>Jones, Alfred E.</au><au>Farkas, Raymond J.</au><au>Miller, Elizabeth E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new 111 in‐bleomycin complex for tumor imaging: Preparation, stability, and distribution in glioma‐bearing mice</atitle><jtitle>Journal of surgical oncology</jtitle><date>1984-03</date><risdate>1984</risdate><volume>25</volume><issue>3</issue><spage>168</spage><epage>175</epage><pages>168-175</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>A new
111
In‐bleomycin complex (
111
In‐BLMC) is here reported. Its radiochemical purity was 99% by thin‐layer chromatography (TLC) (Rf 0.65) and in 5% agarose gel electrophoresis in 0.02 M NaHCO
3
it migrated toward the anode. Autoradiographs of TLC and gel electrophoresis plates showed no change on storage for 3 weeks. Urine and plasma from untreated or glioma‐bearing mice after injection of
111
In‐BLMC were analyzed by TLC and gel electrophoresis. Results indicated stability in vivo, nonbinding to transferrin, affinity to viable tumor, and excretion faster than
111
In‐BLM‐B
2
,
111
In‐BLM, or
57
Co‐BLM. Tissue distributions 24 hr after injection of radiopharmaceutical showed activity ratios of tumor to blood, muscle, and brain of 13.1, 12.4, and 81.6, respectively, which were significantly higher than those for previously prepared
111
In‐BLM‐B
2
or
111
In‐BLM (except for brain, 0.05 < P < 0.1). The new
111
In‐BLM complex may be useful in clinical imaging and for combining radionuclide radiotherapy and chemotherapy.</abstract><doi>10.1002/jso.2930250307</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0022-4790 |
| ispartof | Journal of surgical oncology, 1984-03, Vol.25 (3), p.168-175 |
| issn | 0022-4790 1096-9098 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_jso_2930250307 |
| source | Access via Wiley Online Library |
| title | A new 111 in‐bleomycin complex for tumor imaging: Preparation, stability, and distribution in glioma‐bearing mice |
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