Inhibitory effects of Hibiscus sabdariffa L extract on low-density lipoprotein oxidation and anti-hyperlipidemia in fructose-fed and cholesterol-fed rats
Hibiscus sabdariffa L extract (HSE) is an aqueous extract of Hibiscus sabdariffa L flowers that is used as a local soft drink and medical herb in Taiwan. Oxidation of low-density lipoprotein (LDL) has been shown to increase the incidence of atherosclerosis. In this study, we determined the antioxida...
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| Veröffentlicht in: | Journal of the science of food and agriculture 2004-12, Vol.84 (15), p.1989-1996 |
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| container_end_page | 1996 |
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| container_issue | 15 |
| container_start_page | 1989 |
| container_title | Journal of the science of food and agriculture |
| container_volume | 84 |
| creator | Chen, C.C Chou, F.P Ho, Y.C Lin, W.L Wang, C.P Kao, E.S Huang, A.C Wang, C.J |
| description | Hibiscus sabdariffa L extract (HSE) is an aqueous extract of Hibiscus sabdariffa L flowers that is used as a local soft drink and medical herb in Taiwan. Oxidation of low-density lipoprotein (LDL) has been shown to increase the incidence of atherosclerosis. In this study, we determined the antioxidative activity of HSE on LDL oxidation by examining relative electrophoretic mobilities (REM) and thiobarbituric acid-reactive substances (TBARS). The data revealed an inhibitory effect of HSE on Cu2+-mediated REM and TBARS. HSE exhibited a remarkable ability to reduce cholesterol degradation and ApoB fragmentation. Overall, HSE showed a high potency to inhibit the production of oxidized LDL induced by copper and, specifically, to reduce serum triglycerides in high-fructose diet (HFD) fed rats and serum cholesterol in high-cholesterol diet (HCD) fed animals. The levels of LDL and the ratio of LDL-cholesterol (LDL-C) to HDL-cholesterol (HDL-C) were reduced by HSE in both hyperlipidaemia models. Based on these findings, we suggest that HSE may be used to inhibit LDL oxidation and to prevent various types of hyperlipidaemia in HFD- or HCD-fed rats. |
| doi_str_mv | 10.1002/jsfa.1872 |
| format | Article |
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Oxidation of low-density lipoprotein (LDL) has been shown to increase the incidence of atherosclerosis. In this study, we determined the antioxidative activity of HSE on LDL oxidation by examining relative electrophoretic mobilities (REM) and thiobarbituric acid-reactive substances (TBARS). The data revealed an inhibitory effect of HSE on Cu2+-mediated REM and TBARS. HSE exhibited a remarkable ability to reduce cholesterol degradation and ApoB fragmentation. Overall, HSE showed a high potency to inhibit the production of oxidized LDL induced by copper and, specifically, to reduce serum triglycerides in high-fructose diet (HFD) fed rats and serum cholesterol in high-cholesterol diet (HCD) fed animals. The levels of LDL and the ratio of LDL-cholesterol (LDL-C) to HDL-cholesterol (HDL-C) were reduced by HSE in both hyperlipidaemia models. Based on these findings, we suggest that HSE may be used to inhibit LDL oxidation and to prevent various types of hyperlipidaemia in HFD- or HCD-fed rats.</description><identifier>ISSN: 0022-5142</identifier><identifier>EISSN: 1097-0010</identifier><identifier>DOI: 10.1002/jsfa.1872</identifier><identifier>CODEN: JSFAAE</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>anti-hyperlipidaemia ; antioxidant activity ; antioxidation ; Biological and medical sciences ; blood lipids ; cholesterol ; Feeding. Feeding behavior ; flowers ; Food industries ; food intake ; fructose ; Fundamental and applied biological sciences. Psychology ; Hibiscus sabdariffa ; Hibiscus sabdariffa L ; high density lipoprotein ; high-cholesterol diet ; high-fructose diet ; hyperlipidemia ; lipemic effect ; low density lipoprotein ; medicinal plants ; medicinal properties ; oxidation ; plant extracts ; rats ; triglyceride ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Journal of the science of food and agriculture, 2004-12, Vol.84 (15), p.1989-1996</ispartof><rights>Copyright © 2004 Society of Chemical Industry</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3592-72b673b09626631ff2382aa7cbfd0c4eae10f71902ec47b90b38a81e1ba93d9e3</citedby><cites>FETCH-LOGICAL-c3592-72b673b09626631ff2382aa7cbfd0c4eae10f71902ec47b90b38a81e1ba93d9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjsfa.1872$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjsfa.1872$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16262954$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, C.C</creatorcontrib><creatorcontrib>Chou, F.P</creatorcontrib><creatorcontrib>Ho, Y.C</creatorcontrib><creatorcontrib>Lin, W.L</creatorcontrib><creatorcontrib>Wang, C.P</creatorcontrib><creatorcontrib>Kao, E.S</creatorcontrib><creatorcontrib>Huang, A.C</creatorcontrib><creatorcontrib>Wang, C.J</creatorcontrib><title>Inhibitory effects of Hibiscus sabdariffa L extract on low-density lipoprotein oxidation and anti-hyperlipidemia in fructose-fed and cholesterol-fed rats</title><title>Journal of the science of food and agriculture</title><addtitle>J. Sci. Food Agric</addtitle><description>Hibiscus sabdariffa L extract (HSE) is an aqueous extract of Hibiscus sabdariffa L flowers that is used as a local soft drink and medical herb in Taiwan. Oxidation of low-density lipoprotein (LDL) has been shown to increase the incidence of atherosclerosis. In this study, we determined the antioxidative activity of HSE on LDL oxidation by examining relative electrophoretic mobilities (REM) and thiobarbituric acid-reactive substances (TBARS). The data revealed an inhibitory effect of HSE on Cu2+-mediated REM and TBARS. HSE exhibited a remarkable ability to reduce cholesterol degradation and ApoB fragmentation. Overall, HSE showed a high potency to inhibit the production of oxidized LDL induced by copper and, specifically, to reduce serum triglycerides in high-fructose diet (HFD) fed rats and serum cholesterol in high-cholesterol diet (HCD) fed animals. The levels of LDL and the ratio of LDL-cholesterol (LDL-C) to HDL-cholesterol (HDL-C) were reduced by HSE in both hyperlipidaemia models. Based on these findings, we suggest that HSE may be used to inhibit LDL oxidation and to prevent various types of hyperlipidaemia in HFD- or HCD-fed rats.</description><subject>anti-hyperlipidaemia</subject><subject>antioxidant activity</subject><subject>antioxidation</subject><subject>Biological and medical sciences</subject><subject>blood lipids</subject><subject>cholesterol</subject><subject>Feeding. Feeding behavior</subject><subject>flowers</subject><subject>Food industries</subject><subject>food intake</subject><subject>fructose</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hibiscus sabdariffa</subject><subject>Hibiscus sabdariffa L</subject><subject>high density lipoprotein</subject><subject>high-cholesterol diet</subject><subject>high-fructose diet</subject><subject>hyperlipidemia</subject><subject>lipemic effect</subject><subject>low density lipoprotein</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>oxidation</subject><subject>plant extracts</subject><subject>rats</subject><subject>triglyceride</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0022-5142</issn><issn>1097-0010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNp1kU1v1DAQhi0EEkvhwC_AFw4c3Pojm8THqqJfWgHSUuBmTZwx65LGke2qm5_Cv8XbVHDiYFmaed5XM-8Q8lbwY8G5PLlNDo5F28hnZCW4bhjngj8nq9KTbC0q-ZK8SumWc651Xa_I76tx5zufQ5wpOoc2JxocvSy1ZO8TTdD1EL1zQDcU9zmCzTSMdAgPrMcx-TzTwU9hiiGjH2nY-x6yLwSMfXnZs908YSyM7_HOAy2Qi_c2h4TMYf_I2V0YMGWMYXisRcjpNXnhYEj45uk_IjfnH7-eXbLN54urs9MNs2qtJWtkVzeq47qWda2Ec1K1EqCxneu5rRBQcNcIzSXaquk071QLrUDRgVa9RnVEPiy-NoaUIjozRX8HcTaCm0Om5pCpOWRa2PcLO0GyMLgIo_Xpn6DMIPW6KtzJwj34Aef_G5rr7fnpkzNbFL7EsP-rgPjLlPWatfn-6cJ821bix3X7xfDCv1t4B8HAz1imuNlKLlQ5bC20EuoP5pqiQg</recordid><startdate>200412</startdate><enddate>200412</enddate><creator>Chen, C.C</creator><creator>Chou, F.P</creator><creator>Ho, Y.C</creator><creator>Lin, W.L</creator><creator>Wang, C.P</creator><creator>Kao, E.S</creator><creator>Huang, A.C</creator><creator>Wang, C.J</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200412</creationdate><title>Inhibitory effects of Hibiscus sabdariffa L extract on low-density lipoprotein oxidation and anti-hyperlipidemia in fructose-fed and cholesterol-fed rats</title><author>Chen, C.C ; Chou, F.P ; Ho, Y.C ; Lin, W.L ; Wang, C.P ; Kao, E.S ; Huang, A.C ; Wang, C.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3592-72b673b09626631ff2382aa7cbfd0c4eae10f71902ec47b90b38a81e1ba93d9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>anti-hyperlipidaemia</topic><topic>antioxidant activity</topic><topic>antioxidation</topic><topic>Biological and medical sciences</topic><topic>blood lipids</topic><topic>cholesterol</topic><topic>Feeding. Feeding behavior</topic><topic>flowers</topic><topic>Food industries</topic><topic>food intake</topic><topic>fructose</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hibiscus sabdariffa</topic><topic>Hibiscus sabdariffa L</topic><topic>high density lipoprotein</topic><topic>high-cholesterol diet</topic><topic>high-fructose diet</topic><topic>hyperlipidemia</topic><topic>lipemic effect</topic><topic>low density lipoprotein</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>oxidation</topic><topic>plant extracts</topic><topic>rats</topic><topic>triglyceride</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, C.C</creatorcontrib><creatorcontrib>Chou, F.P</creatorcontrib><creatorcontrib>Ho, Y.C</creatorcontrib><creatorcontrib>Lin, W.L</creatorcontrib><creatorcontrib>Wang, C.P</creatorcontrib><creatorcontrib>Kao, E.S</creatorcontrib><creatorcontrib>Huang, A.C</creatorcontrib><creatorcontrib>Wang, C.J</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Journal of the science of food and agriculture</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, C.C</au><au>Chou, F.P</au><au>Ho, Y.C</au><au>Lin, W.L</au><au>Wang, C.P</au><au>Kao, E.S</au><au>Huang, A.C</au><au>Wang, C.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory effects of Hibiscus sabdariffa L extract on low-density lipoprotein oxidation and anti-hyperlipidemia in fructose-fed and cholesterol-fed rats</atitle><jtitle>Journal of the science of food and agriculture</jtitle><addtitle>J. Sci. Food Agric</addtitle><date>2004-12</date><risdate>2004</risdate><volume>84</volume><issue>15</issue><spage>1989</spage><epage>1996</epage><pages>1989-1996</pages><issn>0022-5142</issn><eissn>1097-0010</eissn><coden>JSFAAE</coden><abstract>Hibiscus sabdariffa L extract (HSE) is an aqueous extract of Hibiscus sabdariffa L flowers that is used as a local soft drink and medical herb in Taiwan. Oxidation of low-density lipoprotein (LDL) has been shown to increase the incidence of atherosclerosis. In this study, we determined the antioxidative activity of HSE on LDL oxidation by examining relative electrophoretic mobilities (REM) and thiobarbituric acid-reactive substances (TBARS). The data revealed an inhibitory effect of HSE on Cu2+-mediated REM and TBARS. HSE exhibited a remarkable ability to reduce cholesterol degradation and ApoB fragmentation. Overall, HSE showed a high potency to inhibit the production of oxidized LDL induced by copper and, specifically, to reduce serum triglycerides in high-fructose diet (HFD) fed rats and serum cholesterol in high-cholesterol diet (HCD) fed animals. The levels of LDL and the ratio of LDL-cholesterol (LDL-C) to HDL-cholesterol (HDL-C) were reduced by HSE in both hyperlipidaemia models. Based on these findings, we suggest that HSE may be used to inhibit LDL oxidation and to prevent various types of hyperlipidaemia in HFD- or HCD-fed rats.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/jsfa.1872</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0022-5142 |
| ispartof | Journal of the science of food and agriculture, 2004-12, Vol.84 (15), p.1989-1996 |
| issn | 0022-5142 1097-0010 |
| language | eng |
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| source | Wiley Journals |
| subjects | anti-hyperlipidaemia antioxidant activity antioxidation Biological and medical sciences blood lipids cholesterol Feeding. Feeding behavior flowers Food industries food intake fructose Fundamental and applied biological sciences. Psychology Hibiscus sabdariffa Hibiscus sabdariffa L high density lipoprotein high-cholesterol diet high-fructose diet hyperlipidemia lipemic effect low density lipoprotein medicinal plants medicinal properties oxidation plant extracts rats triglyceride Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Inhibitory effects of Hibiscus sabdariffa L extract on low-density lipoprotein oxidation and anti-hyperlipidemia in fructose-fed and cholesterol-fed rats |
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