Arylketones and Thiomorpholides in the Synthesis of 8-Substituted-Xanthines

Arylketones and Thiomorpholides in the Synthesis of 8-Substituted-Xanthines

The preparation of 8-aralkyl-theophyllines and related xanthines by reaction of 1,3- dimethyl- 5,6-diaminouracil with appropriate carboxylic acids has been reported This Journal, 43, 152(1954). The extension of this work to include 8-aralkyl- tfaeophyllines substituted in the aralkyl group involved...

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Veröffentlicht in:Journal of the American Pharmaceutical Association (Scientific ed.) 1955-11, Vol.44 (11), p.649-653
Hauptverfasser: Hager, George P., Kramer, Stanley P.
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Sprache:eng
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Ketones
Theophylline - analogs & derivatives
Xanthines
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container_title Journal of the American Pharmaceutical Association (Scientific ed.)
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creator Hager, George P.
Kramer, Stanley P.
description The preparation of 8-aralkyl-theophyllines and related xanthines by reaction of 1,3- dimethyl- 5,6-diaminouracil with appropriate carboxylic acids has been reported This Journal, 43, 152(1954). The extension of this work to include 8-aralkyl- tfaeophyllines substituted in the aralkyl group involved the use of substituted phenylacetic acids, some of which were obtained from arylketones by way of thiomorpholides using the Willgerodt reaction. Both the arylketones and the thiomorpholide intermediates in the Willgerodt reaction have been found to react with l,3-dimethyl-5,6-diaminouracil under the proper conditions to produce the
doi_str_mv 10.1002/jps.3030441102
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ispartof Journal of the American Pharmaceutical Association (Scientific ed.), 1955-11, Vol.44 (11), p.649-653
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subjects Ketones
Theophylline - analogs & derivatives
Xanthines
title Arylketones and Thiomorpholides in the Synthesis of 8-Substituted-Xanthines
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