Synthesis and Pharmacological Evaluation of Oligoethylene Ester Derivatives as Indomethacin Oral Prodrugs

Five indomethacin oligoethylene ester derivatives (3–7) were synthesized and evaluated for their anti‐inflammatory, analgesic, and ulcerogenic activity after oral administration. The molecular weight of the oligoethylene glycols used for synthesizing esters3–7ranged from 106 to 282. The chemical and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1994-11, Vol.83 (11), p.1578-1581
Hauptverfasser:	De Caprariis, Paolo, Palagiano, Francesco, Bonina, Franco, Montenegro, Lucia, D'Amico, Michele, Rossi, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Carrageenan Chromatography, High Pressure Liquid Edema - chemically induced Edema - pathology Esters - chemical synthesis Esters - pharmacokinetics Esters - pharmacology Humans Hydrolysis Indomethacin - analogs & derivatives Indomethacin - pharmacokinetics Indomethacin - pharmacology Male Medical sciences Mice Pain Measurement - drug effects Pharmacology. Drug treatments Prodrugs - chemical synthesis Prodrugs - pharmacokinetics Prodrugs - pharmacology Rats Stomach Ulcer - chemically induced Stomach Ulcer - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!