Simultaneous Determination of Methyl, Ethyl, Propyl, and Butyl 4-Hydroxybenzoates and 4-Hydroxybenzoic Acid in Liquid Antacid Formulations by Gas Chromatography
□ An isothermal chromatographic (GC) method employing an SE-30 column and flame-ionization detection has been developed for the simultaneous assay of methyl, ethyl, propyl, and butyl 4-hydroxybenzoates and 4-hydroxybenzoic acid in liquid antacid formulations. The method, which uses a silica column c...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1984-01, Vol.73 (1), p.128-131 |
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| container_title | Journal of pharmaceutical sciences |
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| creator | Schieffer, Gary W. Palermo, Philip J. Pollard-Walker, Susan |
| description | □ An isothermal chromatographic (GC) method employing an SE-30 column and flame-ionization detection has been developed for the simultaneous assay of methyl, ethyl, propyl, and butyl 4-hydroxybenzoates and 4-hydroxybenzoic acid in liquid antacid formulations. The method, which uses a silica column chromatographic cleanup step prior to GC, is specific for the compounds with respect to possible degradation products, impurities, and excipients. |
| doi_str_mv | 10.1002/jps.2600730136 |
| format | Article |
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The method, which uses a silica column chromatographic cleanup step prior to GC, is specific for the compounds with respect to possible degradation products, impurities, and excipients.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600730136</identifier><identifier>PMID: 6694070</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>4-Hydroxybenzoic acid-simultaneous determination with its methyl ; 4-Hydroxybenzoic acid—simultaneous determination with its methyl, ethyl, propyl, and butyl esters, liquid antacid formulations, gas chromatography ;Antacid formulations—liquid, simultaneous determination of 4-hydroxybenzoic acid and its methyl, ethyl, propyl, and butyl esters, gas chromatography ; 4‐Hydroxybenzoic acid—simultaneous determination with its methyl, ethyl, propyl, and butyl esters, liquid antacid formulations, gas chromatography ; Analysis ; and butyl esters ; Antacid formulations-liquid ; Antacid formulations—liquid, simultaneous determination of 4‐hydroxybenzoic acid and its methyl, ethyl, propyl, and butyl esters, gas chromatography ; Antacids - analysis ; Biological and medical sciences ; Chromatography, Gas - methods ; Drug Stability ; ethyl ; gas chromatography ; General pharmacology ; Hydroxybenzoates - analysis ; liquid antacid formulations ; Medical sciences ; Pharmacology. Drug treatments ; Preservatives, Pharmaceutical - analysis ; propyl ; simultaneous determination of 4-hydroxybenzoic acid and its methyl</subject><ispartof>Journal of pharmaceutical sciences, 1984-01, Vol.73 (1), p.128-131</ispartof><rights>1984 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1984 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4256-2feda49b5efa3817b911bc91b6eba6fa1c0f2706963bc4ff768d4ea853e723283</citedby><cites>FETCH-LOGICAL-c4256-2feda49b5efa3817b911bc91b6eba6fa1c0f2706963bc4ff768d4ea853e723283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600730136$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600730136$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8462049$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6694070$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schieffer, Gary W.</creatorcontrib><creatorcontrib>Palermo, Philip J.</creatorcontrib><creatorcontrib>Pollard-Walker, Susan</creatorcontrib><title>Simultaneous Determination of Methyl, Ethyl, Propyl, and Butyl 4-Hydroxybenzoates and 4-Hydroxybenzoic Acid in Liquid Antacid Formulations by Gas Chromatography</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>□ An isothermal chromatographic (GC) method employing an SE-30 column and flame-ionization detection has been developed for the simultaneous assay of methyl, ethyl, propyl, and butyl 4-hydroxybenzoates and 4-hydroxybenzoic acid in liquid antacid formulations. The method, which uses a silica column chromatographic cleanup step prior to GC, is specific for the compounds with respect to possible degradation products, impurities, and excipients.</description><subject>4-Hydroxybenzoic acid-simultaneous determination with its methyl</subject><subject>4-Hydroxybenzoic acid—simultaneous determination with its methyl, ethyl, propyl, and butyl esters, liquid antacid formulations, gas chromatography ;Antacid formulations—liquid, simultaneous determination of 4-hydroxybenzoic acid and its methyl, ethyl, propyl, and butyl esters, gas chromatography</subject><subject>4‐Hydroxybenzoic acid—simultaneous determination with its methyl, ethyl, propyl, and butyl esters, liquid antacid formulations, gas chromatography</subject><subject>Analysis</subject><subject>and butyl esters</subject><subject>Antacid formulations-liquid</subject><subject>Antacid formulations—liquid, simultaneous determination of 4‐hydroxybenzoic acid and its methyl, ethyl, propyl, and butyl esters, gas chromatography</subject><subject>Antacids - analysis</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Gas - methods</subject><subject>Drug Stability</subject><subject>ethyl</subject><subject>gas chromatography</subject><subject>General pharmacology</subject><subject>Hydroxybenzoates - analysis</subject><subject>liquid antacid formulations</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Preservatives, Pharmaceutical - analysis</subject><subject>propyl</subject><subject>simultaneous determination of 4-hydroxybenzoic acid and its methyl</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFv0zAYxSMEGmVw5YbkA0dSbCexk2Mpa8tUoFIHHC3H-Uw90jjYDiz7a_anki5V0Q6I02d97_f87BdFLwmeEozp2-vWTynDmCeYJOxRNCEZxTHDhD-OJgNA4yRLi6fRM--vMcYMZ9lZdMZYkWKOJ9Hd1uy7OsgGbOfRewjg9qaRwdgGWY0-Qtj19Rt0MY6Ns-1hyqZC77rQ1yiNV33l7E1fQnNrZQB_Lz5cG4VmylTINGhtfnbDadYEedgsrBvi7-M8Knu0lB7Nd87uZbDfnWx3_fPoiZa1hxfHeR59WVxczVfx-vPyw3y2jlVKMxZTDZVMizIDLZOc8LIgpFQFKRmUkmlJFNaUY1awpFSp1pzlVQoyzxLgNKF5ch5Nx3uVs9470KJ1Zi9dLwgWh6bF0LT42_RgeDUa2q7cQ3XCj9UO-uujLr2StXayUcafsDxlFKfFgBUj9tvU0P8nVFxutg-eEI9e4wPcnLzS_RCMJzwT3z4tBd8uNlfb1aX4OvD5yMNQ5C8DTnhloFFQGQcqiMqaf_32DwX9vDQ</recordid><startdate>198401</startdate><enddate>198401</enddate><creator>Schieffer, Gary W.</creator><creator>Palermo, Philip J.</creator><creator>Pollard-Walker, Susan</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198401</creationdate><title>Simultaneous Determination of Methyl, Ethyl, Propyl, and Butyl 4-Hydroxybenzoates and 4-Hydroxybenzoic Acid in Liquid Antacid Formulations by Gas Chromatography</title><author>Schieffer, Gary W. ; Palermo, Philip J. ; Pollard-Walker, Susan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4256-2feda49b5efa3817b911bc91b6eba6fa1c0f2706963bc4ff768d4ea853e723283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>4-Hydroxybenzoic acid-simultaneous determination with its methyl</topic><topic>4-Hydroxybenzoic acid—simultaneous determination with its methyl, ethyl, propyl, and butyl esters, liquid antacid formulations, gas chromatography ;Antacid formulations—liquid, simultaneous determination of 4-hydroxybenzoic acid and its methyl, ethyl, propyl, and butyl esters, gas chromatography</topic><topic>4‐Hydroxybenzoic acid—simultaneous determination with its methyl, ethyl, propyl, and butyl esters, liquid antacid formulations, gas chromatography</topic><topic>Analysis</topic><topic>and butyl esters</topic><topic>Antacid formulations-liquid</topic><topic>Antacid formulations—liquid, simultaneous determination of 4‐hydroxybenzoic acid and its methyl, ethyl, propyl, and butyl esters, gas chromatography</topic><topic>Antacids - analysis</topic><topic>Biological and medical sciences</topic><topic>Chromatography, Gas - methods</topic><topic>Drug Stability</topic><topic>ethyl</topic><topic>gas chromatography</topic><topic>General pharmacology</topic><topic>Hydroxybenzoates - analysis</topic><topic>liquid antacid formulations</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Preservatives, Pharmaceutical - analysis</topic><topic>propyl</topic><topic>simultaneous determination of 4-hydroxybenzoic acid and its methyl</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schieffer, Gary W.</creatorcontrib><creatorcontrib>Palermo, Philip J.</creatorcontrib><creatorcontrib>Pollard-Walker, Susan</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schieffer, Gary W.</au><au>Palermo, Philip J.</au><au>Pollard-Walker, Susan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous Determination of Methyl, Ethyl, Propyl, and Butyl 4-Hydroxybenzoates and 4-Hydroxybenzoic Acid in Liquid Antacid Formulations by Gas Chromatography</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1984-01</date><risdate>1984</risdate><volume>73</volume><issue>1</issue><spage>128</spage><epage>131</epage><pages>128-131</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>□ An isothermal chromatographic (GC) method employing an SE-30 column and flame-ionization detection has been developed for the simultaneous assay of methyl, ethyl, propyl, and butyl 4-hydroxybenzoates and 4-hydroxybenzoic acid in liquid antacid formulations. The method, which uses a silica column chromatographic cleanup step prior to GC, is specific for the compounds with respect to possible degradation products, impurities, and excipients.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>6694070</pmid><doi>10.1002/jps.2600730136</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1984-01, Vol.73 (1), p.128-131 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_jps_2600730136 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | 4-Hydroxybenzoic acid-simultaneous determination with its methyl 4-Hydroxybenzoic acid—simultaneous determination with its methyl, ethyl, propyl, and butyl esters, liquid antacid formulations, gas chromatography Antacid formulations—liquid, simultaneous determination of 4-hydroxybenzoic acid and its methyl, ethyl, propyl, and butyl esters, gas chromatography 4‐Hydroxybenzoic acid—simultaneous determination with its methyl, ethyl, propyl, and butyl esters, liquid antacid formulations, gas chromatography Analysis and butyl esters Antacid formulations-liquid Antacid formulations—liquid, simultaneous determination of 4‐hydroxybenzoic acid and its methyl, ethyl, propyl, and butyl esters, gas chromatography Antacids - analysis Biological and medical sciences Chromatography, Gas - methods Drug Stability ethyl gas chromatography General pharmacology Hydroxybenzoates - analysis liquid antacid formulations Medical sciences Pharmacology. Drug treatments Preservatives, Pharmaceutical - analysis propyl simultaneous determination of 4-hydroxybenzoic acid and its methyl |
| title | Simultaneous Determination of Methyl, Ethyl, Propyl, and Butyl 4-Hydroxybenzoates and 4-Hydroxybenzoic Acid in Liquid Antacid Formulations by Gas Chromatography |
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