Determinants of Bumetanide Response in the Dog: Effect of Indomethacin

Four male unanesthetized dogs each weighing 22.0–29.0kg received 0.250mg/kg iv of bumetanide before (treatment I) and after (treatment II) indomethacin pretreatment. Lactated Ringer’s solution was administered intravenously throughout both treatments at a flow rate of 2ml/min to avoid fluid and elec...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1983-11, Vol.72 (11), p.1298-1302
Hauptverfasser:	Smith, David E., Lau, Henry S.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bumetanide - blood Bumetanide - pharmacology Bumetanide-pharmacokinetics Bumetanide—pharmacokinetics, sodium excretion, dogs, effect of indomethacin pretreatment Diuresis - drug effects Diuretics - pharmacology Dogs Drug Interactions effect of indomethacin pretreatment effect on sodium excretion Indomethacin - pharmacology Indomethacin-pretreatment Indomethacin—pretreatment, effect on sodium excretion, pharmacokinetics of bumetanide, dogs Kinetics Male Medical sciences Natriuresis - drug effects pharmacokinetics in the dog pharmacokinetics of bumetanide Pharmacokinetics-bumetanide Pharmacokinetics—bumetanide, sodium excretion, pharmacokinetics in the dog, effect of indomethacin pretreatment Pharmacology. Drug treatments sodium excretion Urinary system
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