Hydrazine Levels in Formulations of Hydralazine, Isoniazid, and Phenelzine Over a 2-Year Period
□ Hydrazine levels in formulations of hydralazine, isoniazid, and phenelzine have been measured over a 2-year period under ambient conditions and under temperature and humidity stress. Hydralazine tablets are stable under ambient conditions, but the hydrazine level in an injectable formulation incre...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1983-08, Vol.72 (8), p.965-967 |
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| container_issue | 8 |
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| container_title | Journal of pharmaceutical sciences |
| container_volume | 72 |
| creator | Lovering, E.G. Matsui, F. Curran, N.M. Robertson, D.L. Sears, R.W. |
| description | □ Hydrazine levels in formulations of hydralazine, isoniazid, and phenelzine have been measured over a 2-year period under ambient conditions and under temperature and humidity stress. Hydralazine tablets are stable under ambient conditions, but the hydrazine level in an injectable formulation increased from 4.5 to 10μg/ml over a 23-month period. Isoniazid tablets are also stable, but hydrazine levels in an elixir and a pyridoxine combination product doubled to 44μg/ml and 19μg/tablet, respectively. Levels in phenelzine tablets appeared to remain constant at ~60 μg/tablet, with considerable tablet-to-tablet variation. |
| doi_str_mv | 10.1002/jps.2600720836 |
| format | Article |
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Hydralazine tablets are stable under ambient conditions, but the hydrazine level in an injectable formulation increased from 4.5 to 10μg/ml over a 23-month period. Isoniazid tablets are also stable, but hydrazine levels in an elixir and a pyridoxine combination product doubled to 44μg/ml and 19μg/tablet, respectively. Levels in phenelzine tablets appeared to remain constant at ~60 μg/tablet, with considerable tablet-to-tablet variation.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600720836</identifier><identifier>PMID: 6620160</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>and phenelzine over a 2-year period ; Drug Contamination ; Drug Storage ; Hydralazine - analysis ; Hydralazine-hydrazine levels in formulations over a 2-year period ; Hydrazine-levels in formulations of hydralazine ; Hydrazines - analysis ; Hydrazine—levels in formulations of hydralazine, isoniazid, and phenelzine over a 2‐year period ; Hydrazine—levels in formulations of hydralazineiso-niazid, and phenelzine over a 2-year period ; isoniazid ; Isoniazid - analysis ; Isoniazid-hydrazine levels in formulations over a 2-year period ; Phenelzine - analysis ; Phenelzine-hydrazine levels in formulations over a 2-year period ; Solutions ; Tablets - analysis ; Time Factors</subject><ispartof>Journal of pharmaceutical sciences, 1983-08, Vol.72 (8), p.965-967</ispartof><rights>1983 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1983 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4276-3e069eb49c7c8ff794fd1c3d0838d56eeab46c0ead9c1cf121e826f0a70c4ec53</citedby><cites>FETCH-LOGICAL-c4276-3e069eb49c7c8ff794fd1c3d0838d56eeab46c0ead9c1cf121e826f0a70c4ec53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600720836$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600720836$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6620160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lovering, E.G.</creatorcontrib><creatorcontrib>Matsui, F.</creatorcontrib><creatorcontrib>Curran, N.M.</creatorcontrib><creatorcontrib>Robertson, D.L.</creatorcontrib><creatorcontrib>Sears, R.W.</creatorcontrib><title>Hydrazine Levels in Formulations of Hydralazine, Isoniazid, and Phenelzine Over a 2-Year Period</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>□ Hydrazine levels in formulations of hydralazine, isoniazid, and phenelzine have been measured over a 2-year period under ambient conditions and under temperature and humidity stress. Hydralazine tablets are stable under ambient conditions, but the hydrazine level in an injectable formulation increased from 4.5 to 10μg/ml over a 23-month period. Isoniazid tablets are also stable, but hydrazine levels in an elixir and a pyridoxine combination product doubled to 44μg/ml and 19μg/tablet, respectively. Levels in phenelzine tablets appeared to remain constant at ~60 μg/tablet, with considerable tablet-to-tablet variation.</description><subject>and phenelzine over a 2-year period</subject><subject>Drug Contamination</subject><subject>Drug Storage</subject><subject>Hydralazine - analysis</subject><subject>Hydralazine-hydrazine levels in formulations over a 2-year period</subject><subject>Hydrazine-levels in formulations of hydralazine</subject><subject>Hydrazines - analysis</subject><subject>Hydrazine—levels in formulations of hydralazine, isoniazid, and phenelzine over a 2‐year period</subject><subject>Hydrazine—levels in formulations of hydralazineiso-niazid, and phenelzine over a 2-year period</subject><subject>isoniazid</subject><subject>Isoniazid - analysis</subject><subject>Isoniazid-hydrazine levels in formulations over a 2-year period</subject><subject>Phenelzine - analysis</subject><subject>Phenelzine-hydrazine levels in formulations over a 2-year period</subject><subject>Solutions</subject><subject>Tablets - analysis</subject><subject>Time Factors</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMoWqtXb0J-gFsn2d3s7lHE-kFp6xfiKaTJLEa3uyWp1frrjV2peBBPMzDP-8I8hBww6DEAfvw88z0uADIOeSw2SIelHCIBLNsknQDwKE6TYofsev8MAALSdJtsC8GBCegQebE0Tn3YGukAF1h5amvab9z0tVJz29SeNiVdMdWKOqKXvqlt2M0RVbWh4yessVoVjBboqKI8ekTl6Bidbcwe2SpV5XH_e3bJff_s7vQiGozOL09PBpFOeCaiGEEUOEkKnem8LLMiKQ3TsQk_5SYViGqSCA2oTKGZLhlnmHNRgspAJ6jTuEt6ba92jfcOSzlzdqrcUjKQX6JkECV_RIXAYRuYvU6maNb4t5lwL9r7m61w-U-bvBrf_uqO2qz1c3xfZ5V7kSKLs1Q-DM_lTXo9FMVtIW8Cn7d88I8Li056bbHWaKxDPZemsX-98Ql04ZcB</recordid><startdate>198308</startdate><enddate>198308</enddate><creator>Lovering, E.G.</creator><creator>Matsui, F.</creator><creator>Curran, N.M.</creator><creator>Robertson, D.L.</creator><creator>Sears, R.W.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198308</creationdate><title>Hydrazine Levels in Formulations of Hydralazine, Isoniazid, and Phenelzine Over a 2-Year Period</title><author>Lovering, E.G. ; Matsui, F. ; Curran, N.M. ; Robertson, D.L. ; Sears, R.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4276-3e069eb49c7c8ff794fd1c3d0838d56eeab46c0ead9c1cf121e826f0a70c4ec53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>and phenelzine over a 2-year period</topic><topic>Drug Contamination</topic><topic>Drug Storage</topic><topic>Hydralazine - analysis</topic><topic>Hydralazine-hydrazine levels in formulations over a 2-year period</topic><topic>Hydrazine-levels in formulations of hydralazine</topic><topic>Hydrazines - analysis</topic><topic>Hydrazine—levels in formulations of hydralazine, isoniazid, and phenelzine over a 2‐year period</topic><topic>Hydrazine—levels in formulations of hydralazineiso-niazid, and phenelzine over a 2-year period</topic><topic>isoniazid</topic><topic>Isoniazid - analysis</topic><topic>Isoniazid-hydrazine levels in formulations over a 2-year period</topic><topic>Phenelzine - analysis</topic><topic>Phenelzine-hydrazine levels in formulations over a 2-year period</topic><topic>Solutions</topic><topic>Tablets - analysis</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lovering, E.G.</creatorcontrib><creatorcontrib>Matsui, F.</creatorcontrib><creatorcontrib>Curran, N.M.</creatorcontrib><creatorcontrib>Robertson, D.L.</creatorcontrib><creatorcontrib>Sears, R.W.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lovering, E.G.</au><au>Matsui, F.</au><au>Curran, N.M.</au><au>Robertson, D.L.</au><au>Sears, R.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydrazine Levels in Formulations of Hydralazine, Isoniazid, and Phenelzine Over a 2-Year Period</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1983-08</date><risdate>1983</risdate><volume>72</volume><issue>8</issue><spage>965</spage><epage>967</epage><pages>965-967</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>□ Hydrazine levels in formulations of hydralazine, isoniazid, and phenelzine have been measured over a 2-year period under ambient conditions and under temperature and humidity stress. Hydralazine tablets are stable under ambient conditions, but the hydrazine level in an injectable formulation increased from 4.5 to 10μg/ml over a 23-month period. Isoniazid tablets are also stable, but hydrazine levels in an elixir and a pyridoxine combination product doubled to 44μg/ml and 19μg/tablet, respectively. Levels in phenelzine tablets appeared to remain constant at ~60 μg/tablet, with considerable tablet-to-tablet variation.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>6620160</pmid><doi>10.1002/jps.2600720836</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1983-08, Vol.72 (8), p.965-967 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_jps_2600720836 |
| source | MEDLINE; Wiley Journals; Alma/SFX Local Collection |
| subjects | and phenelzine over a 2-year period Drug Contamination Drug Storage Hydralazine - analysis Hydralazine-hydrazine levels in formulations over a 2-year period Hydrazine-levels in formulations of hydralazine Hydrazines - analysis Hydrazine—levels in formulations of hydralazine, isoniazid, and phenelzine over a 2‐year period Hydrazine—levels in formulations of hydralazineiso-niazid, and phenelzine over a 2-year period isoniazid Isoniazid - analysis Isoniazid-hydrazine levels in formulations over a 2-year period Phenelzine - analysis Phenelzine-hydrazine levels in formulations over a 2-year period Solutions Tablets - analysis Time Factors |
| title | Hydrazine Levels in Formulations of Hydralazine, Isoniazid, and Phenelzine Over a 2-Year Period |
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