Comparison of Effects of Cyanide and Acetylcholine on Renal Hemodynamics and Sodium Excretion
The present study compared the effects of acetylcholine to cyanide under the same experimental conditions of renal clearance in anesthetized dogs. Since cyanide is one of the few drugs for which the mechanism of action is known (cytotoxic hypoxia), some insight may be gained into the renal effects o...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1982-01, Vol.71 (1), p.47-50 |
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| creator | Williams, Ronald L. Pearson, James E. Gonzalez, Francisco M. |
| description | The present study compared the effects of acetylcholine to cyanide under the same experimental conditions of renal clearance in anesthetized dogs. Since cyanide is one of the few drugs for which the mechanism of action is known (cytotoxic hypoxia), some insight may be gained into the renal effects of acetylcholine since both produce direct natriuresis and diuresis. Infusion of 0.2 μg/kg/min of acetylcholine and 12.0 μg/kg/min of sodium cyanide into the left renal artery resulted in similar effects, i.e., increased fractional excretion of sodium, potassium, calcium, and magnesium. These effects were immediate and ipsilateral. Both agents increased the renal plasma flow to the same extent. In addition, regression plots of the relation between changes in sodium excretion and changes in renal plasma flow were similar for both agents. The pattern of similar renal functional changes suggested that acetylcholine is not a mere renal vasodilator but that its action is also mediated through alterations on direct tubular transport of ions. |
| doi_str_mv | 10.1002/jps.2600710112 |
| format | Article |
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Since cyanide is one of the few drugs for which the mechanism of action is known (cytotoxic hypoxia), some insight may be gained into the renal effects of acetylcholine since both produce direct natriuresis and diuresis. Infusion of 0.2 μg/kg/min of acetylcholine and 12.0 μg/kg/min of sodium cyanide into the left renal artery resulted in similar effects, i.e., increased fractional excretion of sodium, potassium, calcium, and magnesium. These effects were immediate and ipsilateral. Both agents increased the renal plasma flow to the same extent. In addition, regression plots of the relation between changes in sodium excretion and changes in renal plasma flow were similar for both agents. The pattern of similar renal functional changes suggested that acetylcholine is not a mere renal vasodilator but that its action is also mediated through alterations on direct tubular transport of ions.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600710112</identifier><identifier>PMID: 7057379</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Acetylcholine - pharmacology ; Acetylcholine-effects on renal hemodynamics and sodium secretion ; Acetylcholine—effects on renal hemodynamics and sodium secretion, comparison with cyanide ; Animals ; comparison with acetylcholine ; comparison with cyanide ; Cyanide-effects on renal hemodynamics and sodium secretion ; Cyanides - pharmacology ; Cyanide—effects on renal hemodynamics and sodium secretion, comparison with acetylcholine ; Dogs ; Hemodynamics ; Hemodynamics, renal—effects of cyanide and acetylcholine compared ; Kidney Tubules - drug effects ; Kidney Tubules - metabolism ; Natriuresis - drug effects ; p-Aminohippuric Acid - metabolism ; Parasympathomimetics - pharmacology ; Renal Circulation - drug effects ; renal-effects of cyanide and acetylcholine compared ; Sodium Cyanide - pharmacology</subject><ispartof>Journal of pharmaceutical sciences, 1982-01, Vol.71 (1), p.47-50</ispartof><rights>1982 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1982 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4932-a3ba95e93c738f7d4b7f2b259ccc2332f45a8340160a696babb62623b95e37e43</citedby><cites>FETCH-LOGICAL-c4932-a3ba95e93c738f7d4b7f2b259ccc2332f45a8340160a696babb62623b95e37e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600710112$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600710112$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7057379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, Ronald L.</creatorcontrib><creatorcontrib>Pearson, James E.</creatorcontrib><creatorcontrib>Gonzalez, Francisco M.</creatorcontrib><title>Comparison of Effects of Cyanide and Acetylcholine on Renal Hemodynamics and Sodium Excretion</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>The present study compared the effects of acetylcholine to cyanide under the same experimental conditions of renal clearance in anesthetized dogs. Since cyanide is one of the few drugs for which the mechanism of action is known (cytotoxic hypoxia), some insight may be gained into the renal effects of acetylcholine since both produce direct natriuresis and diuresis. Infusion of 0.2 μg/kg/min of acetylcholine and 12.0 μg/kg/min of sodium cyanide into the left renal artery resulted in similar effects, i.e., increased fractional excretion of sodium, potassium, calcium, and magnesium. These effects were immediate and ipsilateral. Both agents increased the renal plasma flow to the same extent. In addition, regression plots of the relation between changes in sodium excretion and changes in renal plasma flow were similar for both agents. The pattern of similar renal functional changes suggested that acetylcholine is not a mere renal vasodilator but that its action is also mediated through alterations on direct tubular transport of ions.</description><subject>Acetylcholine - pharmacology</subject><subject>Acetylcholine-effects on renal hemodynamics and sodium secretion</subject><subject>Acetylcholine—effects on renal hemodynamics and sodium secretion, comparison with cyanide</subject><subject>Animals</subject><subject>comparison with acetylcholine</subject><subject>comparison with cyanide</subject><subject>Cyanide-effects on renal hemodynamics and sodium secretion</subject><subject>Cyanides - pharmacology</subject><subject>Cyanide—effects on renal hemodynamics and sodium secretion, comparison with acetylcholine</subject><subject>Dogs</subject><subject>Hemodynamics</subject><subject>Hemodynamics, renal—effects of cyanide and acetylcholine compared</subject><subject>Kidney Tubules - drug effects</subject><subject>Kidney Tubules - metabolism</subject><subject>Natriuresis - drug effects</subject><subject>p-Aminohippuric Acid - metabolism</subject><subject>Parasympathomimetics - pharmacology</subject><subject>Renal Circulation - drug effects</subject><subject>renal-effects of cyanide and acetylcholine compared</subject><subject>Sodium Cyanide - pharmacology</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctKxDAUhoMoOo5u3Ql9gY65NMl0OQzjDS-Do7iSkKanmLFthmS89O2NVhQX4uoEzvf_cL4gdEDwiGBMj5arMKICY0kwIXQDDQinOBWYyE00iABNGc_yHbQbwhJjLDDn22hbYi6ZzAfoYeqalfY2uDZxVTKrKjDr8PGcdrq1JSS6LZOJgXVXm0dX2xaSiN5Aq-vkFBpXdq1urAmf3MKV9rlJZm_Gw9q6dg9tVboOsP81h-jueHY7PU0vrk_OppOL1GQ5o6lmhc455MxINq5kmRWyogXluTGGMkarjOsxyzARWItcFLooBBWUFTHEJGRsiEZ9r_EuBA-VWnnbaN8pgtWHJhU1qR9NMXDYB1bPRQPlN_7lJe7zfv9qa-j-aVPn88Wv7rTP2rCGt--s9k9KxHKu7q9OVCbl5SWfLxSL_LjnIRp6seBVMBZaA6X18TNU6exfZ7wDh0OVag</recordid><startdate>198201</startdate><enddate>198201</enddate><creator>Williams, Ronald L.</creator><creator>Pearson, James E.</creator><creator>Gonzalez, Francisco M.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198201</creationdate><title>Comparison of Effects of Cyanide and Acetylcholine on Renal Hemodynamics and Sodium Excretion</title><author>Williams, Ronald L. ; Pearson, James E. ; Gonzalez, Francisco M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4932-a3ba95e93c738f7d4b7f2b259ccc2332f45a8340160a696babb62623b95e37e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Acetylcholine-effects on renal hemodynamics and sodium secretion</topic><topic>Acetylcholine—effects on renal hemodynamics and sodium secretion, comparison with cyanide</topic><topic>Animals</topic><topic>comparison with acetylcholine</topic><topic>comparison with cyanide</topic><topic>Cyanide-effects on renal hemodynamics and sodium secretion</topic><topic>Cyanides - pharmacology</topic><topic>Cyanide—effects on renal hemodynamics and sodium secretion, comparison with acetylcholine</topic><topic>Dogs</topic><topic>Hemodynamics</topic><topic>Hemodynamics, renal—effects of cyanide and acetylcholine compared</topic><topic>Kidney Tubules - drug effects</topic><topic>Kidney Tubules - metabolism</topic><topic>Natriuresis - drug effects</topic><topic>p-Aminohippuric Acid - metabolism</topic><topic>Parasympathomimetics - pharmacology</topic><topic>Renal Circulation - drug effects</topic><topic>renal-effects of cyanide and acetylcholine compared</topic><topic>Sodium Cyanide - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, Ronald L.</creatorcontrib><creatorcontrib>Pearson, James E.</creatorcontrib><creatorcontrib>Gonzalez, Francisco M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, Ronald L.</au><au>Pearson, James E.</au><au>Gonzalez, Francisco M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Effects of Cyanide and Acetylcholine on Renal Hemodynamics and Sodium Excretion</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1982-01</date><risdate>1982</risdate><volume>71</volume><issue>1</issue><spage>47</spage><epage>50</epage><pages>47-50</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>The present study compared the effects of acetylcholine to cyanide under the same experimental conditions of renal clearance in anesthetized dogs. Since cyanide is one of the few drugs for which the mechanism of action is known (cytotoxic hypoxia), some insight may be gained into the renal effects of acetylcholine since both produce direct natriuresis and diuresis. Infusion of 0.2 μg/kg/min of acetylcholine and 12.0 μg/kg/min of sodium cyanide into the left renal artery resulted in similar effects, i.e., increased fractional excretion of sodium, potassium, calcium, and magnesium. These effects were immediate and ipsilateral. Both agents increased the renal plasma flow to the same extent. In addition, regression plots of the relation between changes in sodium excretion and changes in renal plasma flow were similar for both agents. The pattern of similar renal functional changes suggested that acetylcholine is not a mere renal vasodilator but that its action is also mediated through alterations on direct tubular transport of ions.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>7057379</pmid><doi>10.1002/jps.2600710112</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1982-01, Vol.71 (1), p.47-50 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Acetylcholine - pharmacology Acetylcholine-effects on renal hemodynamics and sodium secretion Acetylcholine—effects on renal hemodynamics and sodium secretion, comparison with cyanide Animals comparison with acetylcholine comparison with cyanide Cyanide-effects on renal hemodynamics and sodium secretion Cyanides - pharmacology Cyanide—effects on renal hemodynamics and sodium secretion, comparison with acetylcholine Dogs Hemodynamics Hemodynamics, renal—effects of cyanide and acetylcholine compared Kidney Tubules - drug effects Kidney Tubules - metabolism Natriuresis - drug effects p-Aminohippuric Acid - metabolism Parasympathomimetics - pharmacology Renal Circulation - drug effects renal-effects of cyanide and acetylcholine compared Sodium Cyanide - pharmacology |
| title | Comparison of Effects of Cyanide and Acetylcholine on Renal Hemodynamics and Sodium Excretion |
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