Anticonvulsant Properties of Selected Pyrrolo[2,3-d]Pyrimidine-2,4-diones and Intermediates

A series of pyrrolo[2,3-d]pyrimidine-2,4-diones and intermediates was tested for anticonvulsant activity in mice. Eleven of the 15 compounds possessed anticonvulsant activity against pentylenetetrazol-induced convulsions. One compound afforded more anticonvulsant protection against pentylenetetrazol...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1980-04, Vol.69 (4), p.473-475
Hauptverfasser:	Powers, Debra L., Sowell, J.Walter, Freeman, J.J., Kosh, J.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-d]pyrimidine-2 4-diones and intermediates 4-diones and intermediates-anticonvulsant activity Animals anticonvulsant activity Anticonvulsant activity-pyrrolo Anticonvulsant activity—pyrrolo[2,3-d]pyrimidine-2,4-diones and intermediates, structure-activity relationships Anticonvulsants Electroshock Male Mice Pentylenetetrazole Phenytoin - pharmacology Pyrimidinones - administration & dosage Pyrimidinones - pharmacology Pyrroles - administration & dosage Pyrroles - pharmacology Pyrrolo Pyrrolo[2,3-d]pyrimidine-2,4-diones and intermediates—anticonvulsant activity, structure-activity relationships Seizures - chemically induced Seizures - drug therapy Solubility Structure-Activity Relationship structure-activity relationships Structure-activity relationships-pyrrolo Structure-activity relationships—pyrrolo[2,3-d]pyrimidine-2,4-diones and intermediates, anticonvulsant activity Trimethadione - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!