Thiocardenolides I: Synthesis and Biological Actions of 3β-Thiocyanato-14β-Hydroxy-5β-card-20(22) -enolide

The synthesis of a 3β‐thiocyanatocardenolide is described. The compound exhibited about 0.1 times the cardiotonic effect of digitoxigenin in the isolated frog heart preparation. At a dosage of 20 mg/kg in the intact rat, it elicited ECG changes similar to those seen with a 10‐mg/kg dose of digitoxig...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1976-05, Vol.65 (5), p.765-768
Hauptverfasser:	Abramson, Hanley N., Huang, Chian L., Wu, Thomas F., Tobin, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Adenosine triphosphatase, sodium and potassium activated—effect of 3β‐thiocyanato‐14β‐hydroxy‐5β‐card‐20‐enolide evaluated Cardiotonic agents Cardiotonic agents, potential—3β‐thiocyanato‐14β‐hydroxy‐5β‐card‐20‐enolide synthesized and screened potential-3β-thiocyanato-14β-hydroxy-5β-card-20-enolide synthesized and screened screened for cardiotonic activity and effect on sodium- and potassium-activated adenosine triphosphatase sodium and potassium activated-effect of 3β-thiocyanato-14β-hydroxy-5β-card-20-enolide evaluated Thiocardenolides-3β-thiocyanato-14β-hydroxy-5β-card-20-enolide synthesized Thiocardenolides—3β‐thiocyanato‐14β‐hydroxy‐5β‐card‐20‐enolide synthesized, screened for cardiotonic activity and effect on sodium‐ and potassium‐activated adenosine triphosphatase
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